Anti-hyperlipidemic effects of Campomanesia xanthocarpa aqueous extract and its modulation on oxidative stress and genomic instability in Wistar rats

Sousa, Joubert Aires de; Sousa, José da Silva; Boaretto, Fernanda Brião Menezes; Salvi, Jeferson de Oliveira; Fachini, Jean; Silva, Juliana Bondan da; Unfer, Julia Pereira; Allgayer, Mariangela Costa; Lemes, Maria Luísa Brodt; Marroni, Norma Possa; Ferraz, Alexandre de Barros Falcão; Picada, Jaqueline Nascimento

doi:10.1080/15287394.2019.1683925

Cited by 13 publications

(3 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of NiCl 2 male Wistar rats resulted in an increase in the reduced glutathione content (GSH), glutathione-S-transferase (GST), glutathione reductase (GR), LPO, H 2 O 2 generation, with a concomitant decrease in the activity of glutathione peroxidase (GPx) ( Prasad et al, 2006 ). Several studies reported oxidative damage in brain of rats exposed to nickel with significantly induced increase of LPO, and reduction of GSH level as well as the decrease of superoxide dismutase (SOD) and catalase (CAT) activities ( Ijomone et al, 2020a , Wang et al, 2020 , De Sousa et al, 2019 , Deniz and Altun, 2020 ). In treated male Wistar albino rats, nitric oxide (NO) and LPO levels in whole brain tissue and plasma increased following nickel sulfate (NiSO 4 , 6 H 2 O) treatment ( Ridnour et al, 2004 , Das and Saha, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review

Anyachor¹,

Dooka²,

Orish³

et al. 2022

IBRO Neuroscience Reports

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review

Anyachor¹,

Dooka²,

Orish³

et al. 2022

IBRO Neuroscience Reports

View full text Add to dashboard Cite

“…The most commonly used indicators of lipid peroxidation are TBARS products (De Sousa, 2019). Therefore, TBARS levels were measured in the rat brain to evaluate the Ni-induced lipoperoxidation and modulation by Hyp.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside

Deniz¹,

Altun²

2020

Turk J Zool

View full text Add to dashboard Cite

“…Among the therapeutic properties of leaves and fruits of C. xanthocarpa are the antidiarrheal (Souza-Moreira et al 2011), antioxidant (Pereira et al 2012), and trypanocidal (Salmazzo et al 2019 purposes. This species was also found to exhibit therapeutic properties in metabolic disorders (Cardozo et al 2018), in dyslipidemias prevention (Sousa et al 2019), as well as photoprotective potential (Catelan et al 2019), and antitumoral function (Amaral et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Patterns of genetic diversity, spatial genetic structure and gene flow in Campomanesia xanthocarpa: insights from SSR markers of different genomic origins

Petry

Stefenon

Machado

et al. 2021

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

Campomanesia xanthocarpa (Mart.) O. Berg is a South American fruit tree species with important ecological and medicinal properties, which remnants are currently found mainly in isolated forest fragments. In this study, SSR markers from three different genomic origins (gene-linked, nuclear neutral, and organellar) were used to evaluate the patterns of genetic diversity, fi ne-scale spatial genetic structure and historical gene fl ow in fragmented forest formations of C. xanthocarpa from the Atlantic Forest in southern Brazil. Our results show that the forest fragments present moderate to high levels of genetic diversity in comparison to species presenting similar life traits, although a trend opposite to expected was observed concerning gene-linked and neutral SSR markers. The fi ne-scale spatial genetic structure revealed different patterns in short and large distance classes, with a distinct infl uence of gene-linked and neutral markers in driving the genetic structure in each distance class. The presence of an isolationby-adaptation pattern implies the need for maintenance of the current remnants to assure the conservation of the private alleles. Finally, as the genetic diversity is found predominantly within forest fragments, programs of seed collection and/or genetic rescue should prioritize a larger number of individuals within each fragment, to increase the sampled diversity.

show abstract

Anti-hyperlipidemic effects of Campomanesia xanthocarpa aqueous extract and its modulation on oxidative stress and genomic instability in Wistar rats

Cited by 13 publications

References 53 publications

Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review

Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review

Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside

Patterns of genetic diversity, spatial genetic structure and gene flow in Campomanesia xanthocarpa: insights from SSR markers of different genomic origins

Contact Info

Product

Resources

About