Anti-hyperlipidaemic and antioxidant effects of turmeric oil in hyperlipidaemic rats

Ling, Jingjing; Wei, Bo; Lv, Guangping; Ji, Hui; Li, Shaoping

doi:10.1016/j.foodchem.2011.07.039

Cited by 40 publications

(25 citation statements)

References 26 publications

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“…A high-cholesterol diet can reduce the LDL-C clearance rate of hamsters causing increased LDL-C in the circulation [26]. Decreasing cholesterol and triglyceride levels in blood prevent the risk of cardiovascular diseases and atherosclerosis [31]. In this study, administration of T. indica fruit pulp together with high-cholesterol diet decreased triglyceride, total cholesterol and LDL-C but did not alter HDL-C levels.…”

Section: Discussionmentioning

confidence: 61%

In Vivo Biochemical and Gene Expression Analyses of the Antioxidant Activities and Hypocholesterolaemic Properties of Tamarindus indica Fruit Pulp Extract

et al. 2013

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Background Tamarindus indica (T. indica) is a medicinal plant with many biological activities including anti-diabetic, hypolipidaemic and anti-bacterial activities. A recent study demonstrated the hypolipidaemic effect of T. indica fruit pulp in hamsters. However, the biochemical and molecular mechanisms responsible for these effects have not been fully elucidated. Hence, the aims of this study were to evaluate the antioxidant activities and potential hypocholesterolaemic properties of T. indica, using in vitro and in vivo approaches.Methodology/Principal FindingsThe in vitro study demonstrated that T. indica fruit pulp had significant amount of phenolic (244.9±10.1 mg GAE/extract) and flavonoid (93.9±2.6 mg RE/g extract) content and possessed antioxidant activities. In the in vivo study, hamsters fed with high-cholesterol diet for ten weeks showed elevated serum triglyceride, total cholesterol, HDL-C and LDL-C levels. Administration of T. indica fruit pulp to hypercholesterolaemic hamsters significantly lowered serum triglyceride, total cholesterol and LDL-C levels but had no effect on the HDL-C level. The lipid-lowering effect was accompanied with significant increase in the expression of Apo A1, Abcg5 and LDL receptor genes and significant decrease in the expression of HMG-CoA reductase and Mtp genes. Administration of T. indica fruit pulp to hypercholesterolaemic hamsters also protected against oxidative damage by increasing hepatic antioxidant enzymes, antioxidant activities and preventing hepatic lipid peroxidation.Conclusion/SignificanceIt is postulated that tamarind fruit pulp exerts its hypocholesterolaemic effect by increasing cholesterol efflux, enhancing LDL-C uptake and clearance, suppressing triglyceride accumulation and inhibiting cholesterol biosynthesis. T. indica fruit pulp has potential antioxidative effects and is potentially protective against diet-induced hypercholesterolaemia.

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Section: Discussionmentioning

confidence: 61%

In Vivo Biochemical and Gene Expression Analyses of the Antioxidant Activities and Hypocholesterolaemic Properties of Tamarindus indica Fruit Pulp Extract

et al. 2013

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“…; Ling et al . ). Thus, the high‐fat diet‐mediated elevation of conjugated dienes, lipid hydroperoxides and MDA levels in mitochondria and post‐mitochondria fractions could have resulted from peroxidation of the liver polyunsaturated fatty acids by accumulated ROS (Ming et al .…”

Section: Discussionmentioning

confidence: 97%

Trichosanthes CucumerinaFruit Extenuates Dyslipidemia, Protein Oxidation, Lipid Peroxidation and DNA Fragmentation in the liver of high-fat diet-fed rats

Ajiboye

Akinpelu

Muritala

et al. 2014

Journal of Food Biochemistry

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The effect of Trichosanthes cucumerina fruit pulp extract on dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in the liver of high‐fat diet‐fed rats was investigated. High‐fat diet‐mediated alterations in liver and serum total cholesterol, triacylglycerol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, very‐low‐density lipoprotein cholesterol, alkaline phosphatase, and alanine and aspartate aminotransferase were significantly (P < 0.05) reversed by the T. cucumerina pulp extract. The extract increased the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6‐phosphate dehydrogenase in the mitochondria and post‐mitochondria fractions of rat liver. The increase significantly (P < 0.05) attenuated high‐fat diet‐mediated reductions in antioxidant enzyme activities. High‐fat diet‐mediated elevation in the levels of conjugated dienes, lipid hydroperoxides, malondialdehyde, protein carbonyl and DNA fragmentation in rat liver was dose‐dependently lowered by the extract. The data obtained from this study showed that the T. cucumerina fruit pulp extract palliated high‐fat diet‐mediated dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in rats. Practical Applications Trichosanthes cucumerina fruit pulp can be developed into a nutraceutical product to treat liver disorders. It can also be consumed at home and as substitute to Lycopersicon esculentum (L.) Mill. The fruit pulp of T. cucumerina is sweet tasting, aromatic, deep red in color and does not go sour as quickly as paste of L. esculentum.

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“…Disorganisation of membrane, functional loss, modifications of proteins and DNA bases are consequential effects of lipid peroxidation . Studies have demonstrated the occurrence of lipid peroxidation in high‐fat diet‐fed rats . Thus, the high‐fat diet‐mediated elevation of conjugated dienes, lipid hydroperoxides and malondialdehyde levels in the livers of rats could have resulted from the peroxidation of the polyunsaturated fatty acid by accumulated ROS.…”

Section: Discussionmentioning

confidence: 99%

A fermented sorghum/millet‐based beverage, Obiolor, extenuates high‐fat diet‐induced dyslipidaemia and redox imbalance in the livers of rats

et al. 2015

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Anti-hyperlipidaemic and antioxidant effects of turmeric oil in hyperlipidaemic rats

Cited by 40 publications

References 26 publications

In Vivo Biochemical and Gene Expression Analyses of the Antioxidant Activities and Hypocholesterolaemic Properties of Tamarindus indica Fruit Pulp Extract

In Vivo Biochemical and Gene Expression Analyses of the Antioxidant Activities and Hypocholesterolaemic Properties of Tamarindus indica Fruit Pulp Extract

Trichosanthes CucumerinaFruit Extenuates Dyslipidemia, Protein Oxidation, Lipid Peroxidation and DNA Fragmentation in the liver of high-fat diet-fed rats

A fermented sorghum/millet‐based beverage, Obiolor, extenuates high‐fat diet‐induced dyslipidaemia and redox imbalance in the livers of rats

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