A fermented sorghum/millet‐based beverage, Obiolor, extenuates high‐fat diet‐induced dyslipidaemia and redox imbalance in the livers of rats

Abstract

This study showed that Obiolor extenuated high-fat diet-mediated dyslipidaemia, protein oxidation, lipid peroxidation and DNA fragmentation in rats.

Antidyslipidemic, Anti-Inflammatory, and Antioxidant Activities of Aqueous Leaf Extract ofDioscoreophyllum cumminsii(Stapf) Diels in High-Fat Diet-Fed Rats

“…Lipid peroxidation, protein oxidation, and DNA fragmentation are consequential effects of overwhelmed antioxidant defense system. Elevated levels of lipid peroxidation products, CD, LH, and MDA, in this study are in accordance with previous studies [ 12 , 32 , 37 , 38 ]. This may lead to disorganization and functional loss of membrane [ 39 ].…”

“…Oxidative stress associated with consumption of HFD results from overwhelmed antioxidant enzymes, which act in concerted manner to detoxify reactive oxygen species [ 34 ]. The decreased antioxidant enzymes observed in this study have been documented in HFD-fed rats [ 12 , 32 , 35 , 36 ]. Reversal of HFD-mediated decrease in these enzymes suggests antioxidant activity of the extract, although, in a different animal model, antioxidant activities of D. cumminsii have been reported [ 7 , 8 ].…”

“…Elevated levels of TC, TG, VLDLc, and LDLc with concomitant reduction in HDLc characterize the dyslipidemic changes reported for HFD [ 12 , 31 ]. Indeed, TC, TG, VLDLc, LDLc, and HDLc indicate disordered lipid metabolism and predisposition to cardiovascular disease [ 12 , 31 , 32 ]. These alterations could predispose the risk of developing atherosclerosis and cardiovascular diseases [ 33 ], while reduction in HDL cholesterol could intensify the development of atherosclerosis and cardiovascular diseases.…”

Gluten-Free Cereal Products and Beverages: A Review of Their Health Benefits in the Last Five Years

“…Besides that, Queiroz et al [47] also demonstrated that a powdered drink mix made from sorghum flour which contained tannin showed significant antioxidant activity with a low calorific value. Another study by Ajiboye et al [43] on the effect of a non-alcoholic beverage (obiolor) produced from fermented sorghum and millet malts on the dyslipidemia, protein oxidation, lipid peroxidation, and DNA fragmentation in the liver of rats revealed a significant reduction in the DNA fragmentation, the peroxidation of lipids, protein oxidation, and dyslipidemia in the experimental rats. In addition, the production of a beverage such as tea from the black-colored sorghum variety with a high phenolic content showed a higher antioxidant activity compared to the white-colored variety of sorghum grains [44].…”

“…Has potential for anti-hypertensive and anti-diabetic effects [42] Reducing effects of DNA fragmentation, peroxidation of lipids, and protein oxidation [43] High antioxidative properties [44] Kunnu with tigernut extract has enhanced antioxidative potentials [45] Addition of lactic acid bacteria to beverage made from sorghum and amaranth composites displayed an increased digestibility of protein, increased bio-accessibility of zinc and iron and a higher availability of lysine [46] Powdered drink mix Has antioxidant properties and is low in calories [47] 2.2.1. Health Benefits of Gluten-Free Bread, Pasta, Cookies, and Crackers…”