Trichosanthes CucumerinaFruit Extenuates Dyslipidemia, Protein Oxidation, Lipid Peroxidation and DNA Fragmentation in the liver of high-fat diet-fed rats

Abstract

The effect of Trichosanthes cucumerina fruit pulp extract on dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in the liver of high‐fat diet‐fed rats was investigated. High‐fat diet‐mediated alterations in liver and serum total cholesterol, triacylglycerol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, very‐low‐density lipoprotein cholesterol, alkaline phosphatase, and alanine and aspartate aminotransferase were significantly (P < 0.05) reversed by the T. cucumerina pulp extract. The extract increased the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6‐phosphate dehydrogenase in the mitochondria and post‐mitochondria fractions of rat liver. The increase significantly (P < 0.05) attenuated high‐fat diet‐mediated reductions in antioxidant enzyme activities. High‐fat diet‐mediated elevation in the levels of conjugated dienes, lipid hydroperoxides, malondialdehyde, protein carbonyl and DNA fragmentation in rat liver was dose‐dependently lowered by the extract. The data obtained from this study showed that the T. cucumerina fruit pulp extract palliated high‐fat diet‐mediated dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in rats. Practical Applications Trichosanthes cucumerina fruit pulp can be developed into a nutraceutical product to treat liver disorders. It can also be consumed at home and as substitute to Lycopersicon esculentum (L.) Mill. The fruit pulp of T. cucumerina is sweet tasting, aromatic, deep red in color and does not go sour as quickly as paste of L. esculentum.

Antidiabetic activity‐guided isolation of gallic and protocatechuic acids fromHibiscus sabdariffacalyxes

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The protective effects ofSalvia officinalisessential oil compared to simvastatin against hyperlipidemia, liver, and kidney injuries in mice submitted to a high‐fat diet

“…To counteract oxidative stress, endogenous antioxidant enzymes like superoxide dismutase, catalase, and glutathione peroxidase constitute a defense line against ROS (Amresh et al, ; Amresh, Rao, & Singh, ). In fact, in the present work, enzymatic antioxidants such as SOD, CAT, and GPx were found to decrease in the liver and kidney of hyperlipidemic mice, as reported earlier by Vijayakumar et al () and by Ajiboye et al () in HFD rats. The disruption of the oxidant/antioxidant balance was also confirmed by the histological alterations in the liver and kidney sections of HFD mice.…”

Hibiscus sabdariffa calyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose‐induced metabolic syndrome rats

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