<i>Hibiscus sabdariffa</i>calyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose‐induced metabolic syndrome rats

Ajiboye, Taofeek O.; Raji, Hikmat O; Adeleye, Abdulwasiu O.; Adigun, Nurudeen S.; Giwa, Oluwayemisi B; Ojewuyi, Oluwayemisi B; Oladiji, Adenike Temidayo

doi:10.1002/jsfa.7254

Cited by 35 publications

(28 citation statements)

References 38 publications

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“…Essa et al [ 82 ] reported that HS extracts increased the levels of SOD, CAT and GPx, and reduce glutathione (GSH) in brain tissues of hyperammonemic rats. In addition, several studies in animal models of metabolic syndrome, diabetes or hyperlipidemia have reported an increase in the expression of SOD, CAT, GPx and GR ( Figure 3 ) in several tissues, such as the kidney, liver and heart [ 83 , 84 , 85 , 86 , 87 ]. These studies support the hypothesis that HS extracts are capable of ameliorating oxidative stress in metabolic diseases.…”

Section: Molecular Effects Of Hibiscus Sabdariffa mentioning

confidence: 99%

Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity

et al. 2017

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Improper diet can alter gene expression by breaking the energy balance equation and changing metabolic and oxidative stress biomarkers, which can result in the development of obesity-related metabolic disorders. The pleiotropic effects of dietary plant polyphenols are capable of counteracting by modulating different key molecular targets at the cell, as well as through epigenetic modifications. Hibiscus sabdariffa (HS)-derived polyphenols are known to ameliorate various obesity-related conditions. Recent evidence leads to propose the complex nature of the underlying mechanism of action. This multi-targeted mechanism includes the regulation of energy metabolism, oxidative stress and inflammatory pathways, transcription factors, hormones and peptides, digestive enzymes, as well as epigenetic modifications. This article reviews the accumulated evidence on the multiple anti-obesity effects of HS polyphenols in cell and animal models, as well as in humans, and its putative molecular targets. In silico studies reveal the capacity of several HS polyphenols to act as putative ligands for different digestive and metabolic enzymes, which may also deserve further attention. Therefore, a global approach including integrated and networked omics techniques, virtual screening and epigenetic analysis is necessary to fully understand the molecular mechanisms of HS polyphenols and metabolites involved, as well as their possible implications in the design of safe and effective polyphenolic formulations for obesity.

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Section: Molecular Effects Of Hibiscus Sabdariffa mentioning

confidence: 99%

Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity

et al. 2017

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“…Hibiscus sabdariffa L., roselle, is a functional refreshment drink widely consumed in developing countries including Nigeria (Ajiboye et al, ). In Nigeria, it is called “ zoborodo ” and taken as a refreshment during ceremonial gatherings (Ajiboye, Raji, et al, ). The consumption is not limited to ceremonial gatherings owing to the awareness of its functional capability.…”

Section: Introductionmentioning

confidence: 99%

“…The consumption is not limited to ceremonial gatherings owing to the awareness of its functional capability. The functional use of H. sabdariffa includes as antidiabetic, antihypertensive, hypolipidemic, antimetabolic syndrome, anticancer metastasis, neuroprotective hepatoprotective, and vasorelaxant (Ajiboye et al, ; Ajiboye, Raji, et al, ; Griffin et al, ; Igoli, Drummond, Ferro, Zheoat, & Gray, ; Jabeur et al, ; Su, Wang, et al, ). The chemical components of H. sabdariffa responsible for these activities are catechin, gallic acid, caffeic acid, and protocatechuic acid (Da‐Costa‐Rocha, Bonnlaender, Sievers, Pischel, & Heinrich, ).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic activity‐guided isolation of gallic and protocatechuic acids fromHibiscus sabdariffacalyxes

et al. 2019

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We isolated and identified gallic and protocatechuic acids as the antidiabetic principles in Hibiscus sabdariffa using solvent extraction, column chromatographic fractionation, and nuclear magnetic resonance (NMR) spectroscopy. Ethylacetate fraction of the aqueous extract of H. sabdariffa inhibited α‐amylase and α‐glucosidase with IC50 of 411.73 and 433.93 μg/ml, respectively. Furthermore, fractions I and II obtained from column chromatography inhibited α‐amylase with IC50 of 27.03 and 20.12 μg/ml, and α‐glucosidase with IC50 of 24.30 and 22.29 μg/ml, respectively. In addition, the principles reduced the serum glucose and lipid peroxide levels of diabetic rats and with an improvement in the rat lipid profiles and antioxidant defenses. Fractions I and II were identified as protocatechuic acid and gallic acid, respectively, using 1H and 13C NMR. Protein–ligand docking showed that these compounds form multiple favorable interactions with the active‐site residues of the two glycosidases. Overall, protocatechuic and gallic acids emerge as natural antidiabetic agents. Practical applications Hibiscus sabdariffa (Zoborodo) is a refreshment drink for ceremonial gatherings in Nigeria. Also, its pharmacological use includes diabetes, hypertension, hyperlipidemia, metabolic syndrome, and hepatoprotection. The consumption of this food drink could improve diabetes, hypertension, dyslipidemia, metabolic syndrome, and liver disease. Furthermore, the inhibition of α‐amylase and α‐glucosidase could prevent diabetic complications associated with postprandial glucose. Developing the extract of H. sabdariffa calyx as food supplement could be used in managing diabetes and its associated complications such as dyslipidemia, hypertension, and metabolic syndrome.

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“…Its rose-color petals are used in drinks as food coloring and its fruit is used to make fruit preservatives, syrups, and jams. As a traditional medicine, roselle is primarily used as a remedy for coughs2 but is also used as anti-hypertensive34, anti-hyperlipidemia56, anti-nociceptive, anti-pyretic, anti-inflammatory7, and diuretic agents89. Previous studies have shown that the roselle calyx extract contains proteinase inhibitors against angiotensin I converting enzyme, elastase, trypsin, and alpha-chymotrypsin10; however, the chemical nature of these proteinase inhibitors remains unexplored.…”

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confidence: 99%

Identification and Characterization of Roseltide, a Knottin-type Neutrophil Elastase Inhibitor Derived from Hibiscus sabdariffa

Loo

Kam

Xiao

et al. 2016

Sci Rep

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Plant knottins are of therapeutic interest due to their high metabolic stability and inhibitory activity against proteinases involved in human diseases. The only knottin-type proteinase inhibitor against porcine pancreatic elastase was first identified from the squash family in 1989. Here, we report the identification and characterization of a knottin-type human neutrophil elastase inhibitor from Hibiscus sabdariffa of the Malvaceae family. Combining proteomic and transcriptomic methods, we identified a panel of novel cysteine-rich peptides, roseltides (rT1-rT8), which range from 27 to 39 residues with six conserved cysteine residues. The 27-residue roseltide rT1 contains a cysteine spacing and amino acid sequence that is different from the squash knottin-type elastase inhibitor. NMR analysis demonstrated that roseltide rT1 adopts a cystine-knot fold. Transcriptome analyses suggested that roseltides are bioprocessed by asparagine endopeptidases from a three-domain precursor. The cystine-knot structure of roseltide rT1 confers its high resistance against degradation by endopeptidases, 0.2 N HCl, and human serum. Roseltide rT1 was shown to inhibit human neutrophil elastase using enzymatic and pull-down assays. Additionally, roseltide rT1 ameliorates neutrophil elastase-stimulated cAMP accumulation in vitro. Taken together, our findings demonstrate that roseltide rT1 is a novel knottin-type neutrophil elastase inhibitor with therapeutic potential for neutrophil elastase associated diseases.

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Hibiscus sabdariffacalyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose‐induced metabolic syndrome rats

Abstract: Overall, aqueous extract of H. sabdariffa palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in high-fructose-induced metabolic syndrome rats.

Cited by 35 publications

References 38 publications

Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity

Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity

Antidiabetic activity‐guided isolation of gallic and protocatechuic acids fromHibiscus sabdariffacalyxes

Identification and Characterization of Roseltide, a Knottin-type Neutrophil Elastase Inhibitor Derived from Hibiscus sabdariffa

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