Anti-hyperglycemic, antioxidant, and anti-inflammatory activities of extracts and metabolites from Sida acuta and Sida rhombifolia

Arciniegas, Amira; Pérez-Castorena, Ana L.; Nieto‐Camacho, Antonio; Kita, Yuko; Vivar, Alfonso Romo de

doi:10.21577/0100-4042.20160182

Cited by 8 publications

(7 citation statements)

References 13 publications

(18 reference statements)

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“…It is used as a tonic and astringent and for treatments of urinary, bile, hepatic and nervous disorders [11,12]. Pharmacologically, S. acuta has been reported for inhibitory activities against Anopheles stephensi [13], antioxidants [14], antiulcer [15], wound healing [16] cardioprotective [17], antidiabetic [18] and antibacterial activities [19,20]. Previous studies on the crude extract of S. acuta have shown markedly antimalarial activities in both in vitro (IC 50 0.05 µg/ml compared to < 0.042 µg/ml for chloroquine) and in vivo models [21,22].…”

Section: Introductionmentioning

confidence: 99%

Antiplasmodial effect and sub-acute toxicity of alkaloid, flavonoid and phenolic extracts of Sida acuta leaf on Plasmodium berghei-infected animals

Adesina

Adefolalu

Jigam

et al. 2020

Journal of Taibah University for Science

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The antiplasmodial and safety profile of alkaloid, flavonoid and phenol extracts of Sida acuta (300 and 600 mg/kgbw) on hepatic and renal integrity of rats were investigated. Alkaloid, flavonoid and phenol extracts produce parasitaemia suppression of 50.83%, 33.50% and 64.64%, respectively. Sub-chronic administration of the phytochemicals caused marked (p < 0.05) dosedependent increase in erythrocytic and leucocytic indices while serum ALP, AST, ALT, albumin, urea and creatinine concentrations compared well (p > 0.05) with the controls. Total proteins, sodium and chloride levels were altered in rats treated with 300 mg/kgbw of the phytochemicals. The integrity of hepatocytes and renal cells increases with increase extract concentrations and no degenerative changes were observed in all treatment groups. However, flavonoid extract caused severe renal vacuolation at 300 mg/kgbw which cleared out at 600 mg/kgbw. Conclusively, phenol exhibited higher antiplasmodial activities and safety profile and thus could be considered a potential candidate for the development of a new drug.

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Section: Introductionmentioning

confidence: 99%

Antiplasmodial effect and sub-acute toxicity of alkaloid, flavonoid and phenolic extracts of Sida acuta leaf on Plasmodium berghei-infected animals

Adesina

Adefolalu

Jigam

et al. 2020

Journal of Taibah University for Science

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“…Para-hydroxyphenethyl trans-ferulate and beta-sitosteryl glucopyranoside isolated from these Sida spp. were reported as active compounds [8]. For alpha-amylase, most dichloromethane fractions had stronger inhibitory activity than methanolic fractions except the stems of A. indicum and M. coromandelianum.…”

Section: Discussionmentioning

confidence: 94%

In Vitro Antidiabetic Potentials of Sida Acuta, Abutilon Indicum and Malvastrum Coromandelianum

Dinlakanont¹,

Palanuvej²,

Ruangrungsi³

2020

Int J Curr Pharm Sci

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Objective: Starch metabolizing enzyme inhibitors are able to retard postprandial glucose absorption. This study aimed to investigate the in vitro inhibitory activities of alpha-glucosidase and alpha-amylase of three Malvaceous weeds i.e. Sidaacuta Burm. f., Abutilon indicum (Linn.) Sweet and Malvastrumcoromandelianum (Linn.) Garcke. Methods: The stems, roots and leaves of S. acuta, A. indicum and M. coromandelianum were sequentially extracted in dichloromethane and methanol, respectively. All fractions were tested for the inhibitory activities on yeast alpha-glucosidase, rat intestinal alpha-glucosidase and porcine alpha-amylase. p-Nitrophenyl-α-D-glucopyranoside and 2-chloro-4 nitrophenol-α-D- maltotrioside were used as the substrate for glucosidase and amylase respectively. Results: The dichloromethane fraction of the roots and stems from A. indicum and dichloromethane as well as methanolic fractions of the stems of M. coromandelianum could inhibit yeast alpha-glucosidase compared to 1-deoxynojirimycin with the IC50 of 0.36, 0.45, 0.48, 0.48 and 0.58 mg/ml respectively. A. indicum root methanolic fraction had the highest inhibitory effect on rat alpha-glucosidase activity compared to 1-deoxynojirimycin with the IC50 of 0.08 and 0.11 mg/ml respectively. M. coromandelianum, the dichloromethane fraction of roots and the methanolic fraction of stems, showed the strongest effect on alpha-amylase inhibition compared to acarbose with the IC50 of 0.07, 0.07 and 2.7 mg/ml, respectively. Conclusion: S. acuta, A. indicum and M. coromandelianum dichloromethane and methanolic fractions of the root, stem and leaf parts demonstrated an appreciable inhibitory activity on alpha-amylase from porcine, alpha-glucosidase from Saccharomyces cerevisiae and from rat intestine compared to 1-deoxynojirimycin and acarbose.

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“…TNW70M/TNW80M fractions also contained p-hydroxyphenethyl trans-ferulate which has previously shown strong inhibitory activity on yeast α-glucosidase (IC 50 = 19.24 μmol/L), comparable to the reference quercetin (IC 50 = 15.61 μmol/L) [ 82 ]. Other abundant metabolites in TNW30M/TNW40M with previously described α-glucosidase inhibitory activity included rhein which has shown strong activity with IC 50 value of 5.68 μM [ 83 ].…”

Section: Resultsmentioning

confidence: 99%

In vitro α-glucosidase inhibitory activity of Tamarix nilotica shoot extracts and fractions

et al. 2022

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α-glucosidase inhibitors represent an important class of type 2 antidiabetic drugs and they act by lowering postprandial hyperglycemia. Today, only three synthetic inhibitors exist on the market, and there is a need for novel, natural and more efficient molecules exhibiting this activity. In this study, we investigated the ability of Tamarix nilotica ethanolic and aqueous shoot extracts, as well as methanolic fractions prepared from aqueous crude extracts to inhibit α-glucosidase. Both, 50% ethanol and aqueous extracts inhibited α-glucosidase in a concentration-dependent manner, with IC50 values of 12.5 μg/mL and 24.8 μg/mL, respectively. Importantly, α-glucosidase inhibitory activity observed in the T. nilotica crude extracts was considerably higher than pure acarbose (IC50 = 151.1 μg/mL), the most highly prescribed α-glucosidase inhibitor on the market. When T. nilotica crude extracts were fractionated using methanol, enhanced α-glucosidase inhibitory activity was observed in general, with the highest observed α-glucosidase inhibitory activity in the 30% methanol fraction (IC50 = 5.21 μg/mL). Kinetic studies further revealed a competitive reversible mechanism of inhibition by the plant extract. The phytochemical profiles of 50% ethanol extracts, aqueous extracts, and the methanolic fractions were investigated and compared using a metabolomics approach. Statistical analysis revealed significant differences in the contents of the crude extracts and fractions and potentially identified the molecules that were most responsible for these observed variations. Higher α-glucosidase inhibitory activity was associated with an enrichment of terpenoids, fatty acids, and flavonoids. Among the identified molecules, active compounds with known α-glucosidase inhibitory activity were detected, including unsaturated fatty acids, triterpenoids, and flavonoid glycosides. These results put forward T. nilotica as a therapeutic plant for type 2 diabetes and a source of α-glucosidase inhibitors.

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Anti-hyperglycemic, antioxidant, and anti-inflammatory activities of extracts and metabolites from Sida acuta and Sida rhombifolia

Cited by 8 publications

References 13 publications

Antiplasmodial effect and sub-acute toxicity of alkaloid, flavonoid and phenolic extracts of Sida acuta leaf on Plasmodium berghei-infected animals

Antiplasmodial effect and sub-acute toxicity of alkaloid, flavonoid and phenolic extracts of Sida acuta leaf on Plasmodium berghei-infected animals

In Vitro Antidiabetic Potentials of Sida Acuta, Abutilon Indicum and Malvastrum Coromandelianum

In vitro α-glucosidase inhibitory activity of Tamarix nilotica shoot extracts and fractions

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