Anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) Willd. Ex. Del.

Singh, Rajbir; Singh, Bikram; Singh, Sukhpreet; Kumar, Neeraj; Kumar, Subodh; Arora, Saroj

doi:10.1016/j.tiv.2008.08.007

Cited by 109 publications

(70 citation statements)

References 23 publications

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“…An infusion is taken internally in the treatment of bronchial complaints and coughs, insomnia, poor digestion, nervous digestive disorders and minor painful conditions. The flowers are also used in the treatment of jaundice and -in very small quantities-as a sleep-inducing drug [9,10].Papaver rhoeas plant extract contains a lot of flavonoids: kaempferol, quercetin, luteolin and hypolaetin andAntioxidant activity of the kaempferol [12][13], quercetin [14][15] and luteolin [16] was already demonstrated. Total phenolic compounds (9.73 -19.91 mg GAE/g) and total flavonoids (7.904-11.45 mg QE/g) were determined in fresh petals [17].…”

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confidence: 99%

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Biological activity of plant extract isolated from Papaver rhoeas on human lymfoblastoid cell line

Hašplová¹,

Hudecová²,

Miadoková³

et al. 2011

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Varied medicinal plants are known as a source of natural phytochemicals with antioxidant activities that can protect organisms from oxidative stress and from various chronic diseases. Papaver rhoeas has a long history of medicinal usage, especially for ailments in adults and children. The possible cytotoxicity, genotoxicity and potential antioxidant effect of plant extract isolated from flowers of Papaver rhoeas was investigated in human lymfoblastoid cell line (TK6). Antioxidant activity of this extract was determined using the DPPH assay. The plant extract exhibited dose dependent free radical scavenging ability. The growth activity assay was used for determination of cytotoxicity. To assess potential genotoxicity the comet assay was used. The lower extract concentrations (0.25 and 0.5 mg/ml) neither exerted cytotoxic, nor genotoxic effects in TK6 cells but they stimulated cell proliferation. The concentration 25 mg/ml scavenged almost 85% of DPPH free radical. On the other hand, this concentration had strong cytotoxic and genotoxic effect on TK6 cells.The balance between beneficial and harmful effects should be always considered when choosing the effective dose. Plants are universally recognized as a vital part of the world's natural heritage and up to 80% of the population relies on plants for their contribution to a primary healthcare. The use of plants in traditional medicine is widespread. Many plants still represent a large source of natural antioxidants that might serve as leads for the development of novel drugs. It is commonly accepted that due to oxidative stress, reactive oxygen species (ROS) such as superoxid, hydroxyl and peroxyl radicals are generated [1]. Recently much attention has been given to the natural phytochemicals with antioxidant, antimutagenic and anticarcinogenic activities [2][3][4][5][6][7][8]. These compounds are of great importance for chemoprevention and potential cancer biotherapy.Papaveraceae is a family of flowering plants. The flowers of poppy are chiefly employed as a mild pain reliever and as a treatment for irritable coughs; it also helps to reduce nervous over-activity [9]. The flowers and petals are anodyne, expectorant, hypnotic, slightly narcotic and sedative. An infusion is taken internally in the treatment of bronchial complaints and coughs, insomnia, poor digestion, nervous digestive disorders and minor painful conditions. The flowers are also used in the treatment of jaundice and -in very small quantities-as a sleep-inducing drug [9,10].Papaver rhoeas plant extract contains a lot of flavonoids: kaempferol, quercetin, luteolin and hypolaetin andAntioxidant activity of the kaempferol [12][13], quercetin [14][15] and luteolin [16] was already demonstrated. Total phenolic compounds (9.73 -19.91 mg GAE/g) and total flavonoids (7.904-11.45 mg QE/g) were determined in fresh petals [17].Besides flavonoids and their glycosides Papaveraceae family are known for the presence of alkaloids as morphine, codeine, narcotine, thebaine and papaverine [8,18,19].The aim of this study...

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“…Antioxidant activity of the kaempferol [12][13], quercetin [14][15] and luteolin [16] was already demonstrated. Total phenolic compounds (9.73 -19.91 mg GAE/g) and total flavonoids (7.904-11.45 mg QE/g) were determined in fresh petals [17].…”

mentioning

confidence: 99%

Biological activity of plant extract isolated from Papaver rhoeas on human lymfoblastoid cell line

Hašplová¹,

Hudecová²,

Miadoková³

et al. 2011

neo

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“…The NMR spectrum data from glabridin was similar to that of compound A. Equally, compound C, D, E were identified as keampferol, naringenin, allmandicin respectively [13][14][15].…”

Section: Compounds Identificationmentioning

confidence: 66%

Isolation, Identification and Tyrosinase Inhibitory Activities of the Extractives from Allamanda cathartica

Yamauchi¹,

Mitsunaga²,

Batubara³

2011

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“…It is well documented that A.nilotica is one of the rich source of these flavonoids and phenolics. For example, the polyphenolic compound Kaempferol displayed radical scavenging activity in different in vitro assays (Rajbir et al, 2008). Niloticane isolated from the bark of the A.nilotica showed antiinflammatory property by inhibition of Cyclooxygenase enzymes which is involved in inflammatory process (Eldeen et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Anticancer Activity of Acacia nilotica (L.) Wild. Ex. Delile Subsp. indica Against Dalton's Ascitic Lymphoma Induced Solid and Ascitic Tumor Model

Sakthivel¹,

Kannan²,

Angeline³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Effect of Acacia nilotica Against Dalton's Ascitic Lymphoma ModelAsian Pacific J Cancer Prev, 13, 3989-3995 IntroductionOver the past decade, Cancer is the leading cause of death worldwide and it is characterized by uncontrolled growth and spread of abnormal cells. World Health Organization (WHO) reported that there are 7.6 million deaths in 2008 and it is estimated up to 13.1 million deaths in 2030 (Merel et al., 2012). Treatment of cancer varies according to each type, has been facing large number of problems. Several ways in the treatment of cancer have been developed. Currently cancer is treated using surgery, radiation, and chemotherapy which are associated with severe side effects (Garcia et al., 2001;Edy et al., 2012). Even a large number of tumors are scantily responsive to cancer therapeutic drugs and radiotherapy. Identification and development of natural products used for cancer prevention have attracted a lot of attention globally. Herbal extracts with their proven potential and less side effects in therapeutics has replaced the synthetically derived drugs in modern allopathic medication system (Sakthivel and Guruvayoorappan, 2012). Traditionally used large number of medicinal plants and plant products has become the potential source of antitumor agents. Traditional healers of different regions in India particularly Chhattisgarh used Acacia species for treatment of various cancer types of mouth, bone and skin (Kalaivani and Mathew, 2010

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Anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) Willd. Ex. Del.

Cited by 109 publications

References 23 publications

Biological activity of plant extract isolated from Papaver rhoeas on human lymfoblastoid cell line

Biological activity of plant extract isolated from Papaver rhoeas on human lymfoblastoid cell line

Isolation, Identification and Tyrosinase Inhibitory Activities of the Extractives from Allamanda cathartica

Anticancer Activity of Acacia nilotica (L.) Wild. Ex. Delile Subsp. indica Against Dalton's Ascitic Lymphoma Induced Solid and Ascitic Tumor Model

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