Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway

Wang, Jia; Wang, Cong; Li, Shuqin; Li, Weiwei; Yuan, Guoqi; Pan, Ying‐Ming; Chen, Hạixia

doi:10.1016/j.biopha.2017.09.104

Cited by 106 publications

(64 citation statements)

References 50 publications

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“…These results indicate that isopulegol has significant lipid lowering effect in diabetic treated rats. Our findings are in line with wang et al who reported that Inonotus obliques polysaccharides normalized lipid profile in streptozocin diabetic rats [25].…”

Section: Discussionsupporting

confidence: 94%

Isopulegol Ameliorates Dyslipidemia by Modulating Adipokine Secretion in High Fat Diet / Streptozotocin Induced Diabetic Rats

Kalaivani¹,

Sankaranarayanan²

2019

J. Drug Delivery Ther.

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The present study investigates the effect of isopulegol on adipokine secretion and dyslipidemia in high fat diet and streptozotocin (HFD/STZ) induced diabetic rats. Animals were made diabetic by feeding HFD for 4 wks followed by single intraperitoneal injection of STZ (35mg/kg b.w; 0.1M citrate buffer; pH 4.0). Diabetic rats showed increased levels of total cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein-C (LDL-C), very low density lipoprotein -C (VLDL-C) and decreased high density lipoprotein-C levels (HDL-C). Similarly, the activity of HMG-CoA reductase, was increased while lipoprotein lipase (LPL) and lecithin cholesterol acyl transferase (LCAT) activities were significantly decreased. Furthermore, the expression of sterol regulatory element binding protein-1C (SREBP-1C), adiponectin, peroxisome proliferator activated receptor gamma (PPARγ) were significantly down regulated, whereas leptin expression was upregulated in diabetic rats. Administration of isopulegol (100 mg/kg b.w) for 28 days signiﬁcantly restored lipid levels in plasma and liver tissue by modulating adipokine secretion in diabetic treated rats. From this we conclude that isopulegol exhibited significant antihyperlipidemic effect in HFD/STZ induced diabetic rats. Keywords: Dyslipidemia, Diabetes mellitus, Adiponectin, Leptin, PPARγ, SREBP-1C

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Section: Discussionsupporting

confidence: 94%

Isopulegol Ameliorates Dyslipidemia by Modulating Adipokine Secretion in High Fat Diet / Streptozotocin Induced Diabetic Rats

Kalaivani¹,

Sankaranarayanan²

2019

J. Drug Delivery Ther.

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“…In the present study, oral administration of three polysaccharides (En-, Ac-, and Al-MSP) significantly decreased GLU levels in STZ-induced diabetic mice, which was also confirmed by Wang et al [ 28 ]. Moreover, the polysaccharides had the potential to improve the weight loss in diabetic mice, and the underlying mechanism may be attributable to the ability of polysaccharides to improve glucose homeostasis [ 15 ].…”

Section: Discussionsupporting

confidence: 90%

Characterization and Attenuation of Streptozotocin‐Induced Diabetic Organ Damage by Polysaccharides from Spent Mushroom Substrate (Pleurotus eryngii)

Liu

Yao

Zhao

et al. 2018

Oxidative Medicine and Cellular Longevity

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The aim of this work was to characterize spent mushroom substrate polysaccharides (MSP) from Pleurotus eryngii and their antioxidant and organ protective effects in streptozotocin- (STZ-) induced diabetic mice. The enzymatic-, acidic-, and alkalic- (En-, Ac-, and Al-) MSP were extracted from P. eryngii with snailase (4%), hydrochloric acid (1 mol/l), and sodium hydroxide (1 mol/l), respectively. The characterizations were evaluated by spectral analysis. In animal experiments, the enzymatic activities, lipid peroxide contents, and serum lipid parameters were measured, and histological observations of the liver, kidney, pancreas, and heart were conducted. The results demonstrated that treatment with En-, Ac-, and Al-MSP increased the organ enzymatic activities, decreased the organ lipid peroxide contents, mitigated the serum biochemistry values, and ameliorated the histopathology of diabetic mice, indicating that En-, Ac-, and Al-MSP could potentially be used as functional foods for the prevention of diabetes.

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“…In addition, tyrosine phosphorylation of IRS1 can activate the PI3K pathway to induce phosphorylation of Akt, which is an important mediator related to insulin's downstream metabolic actions. GSK3β activity can be inactivated by insulin signaling through insulin receptor IRS1, PI3K, and the action of Akt to phosphorylate specific serine residues on the enzyme (Wang et al, , ). Therefore, the activation of Akt leads to inactivation of GSK3β, which in turn enhances the expression of GS protein, potentially, on glucose transport activity.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ‐induced diabetic rats

Wei

Zhan

et al. 2020

Food Science & Nutrition

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Agaricus blazei Murrill (ABM) is an edible fungus. This study investigated the protective role of ABM fruiting body against streptozotocin (STZ)‐induced diabetic rats. After 4 weeks of ABM supplement, glucose homeostasis was improved in diabetic rats. Quantitative real‐time and Western blot analyses suggested that ABM could promote the gene and protein expression level of insulin receptor, pyruvate dehydrogenase kinase, phospho‐kinase B, kinase B, phosphatidylinositol 3‐kinase, insulin receptor substrate 1, glucose transporter‐4, and glutamine synthetase, while inhibiting the expression of glycogen synthase kinase 3β and c‐jun N‐terminal kinase 1 and 2. According to multivariate and univariate statistical analysis, liver metabolite profiles of the normal and diabetic rats fed basal and experimental diet were clearly separated. The differential liver metabolites from diabetic rats fed basal and ABM diet‐related pathways including the glycolysis pathway, pentose phosphate pathway, tricarboxylic acid cycle, and oxidative phosphorylation were analyzed. A total of 18 potential biomarker metabolites were identified as differential biomarkers associated with ABM supplement diet.

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Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway

Cited by 106 publications

References 50 publications

Isopulegol Ameliorates Dyslipidemia by Modulating Adipokine Secretion in High Fat Diet / Streptozotocin Induced Diabetic Rats

Isopulegol Ameliorates Dyslipidemia by Modulating Adipokine Secretion in High Fat Diet / Streptozotocin Induced Diabetic Rats

Characterization and Attenuation of Streptozotocin‐Induced Diabetic Organ Damage by Polysaccharides from Spent Mushroom Substrate (Pleurotus eryngii)

Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ‐induced diabetic rats

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