Biomaterials are strategies that allow researchers to expand the investigative aspects and identify potential for the composition of objectives for clinical use. This study aims to evaluate the use of biocompounds with antimicrobial action as an alternative in the coating of endotracheal tubes. The methodology used was a narrative review of the bibliography. To this end, the northern question was elaborated according to the PICo strategy. The databases consulted were: PubMed, Embase, Lilacs; using the descriptors: Biomaterial, Biopolymer, Polymer, Endotracum tube, Mechanical ventilation, Orotracqueal tube, Pneumonia, Pneumonia associated with mechanical ventilation. Reports of relevant activity of biocompounds against biofilm-making pathogens were observed inside the tubes, especially Staphylococcus aureus and Staphylococcus pneumoniae. Thus, the results obtained report a new perspective from the point of view of prevention and combating infections associated with endotracheal intubation, which is an alternative for the construction of hospital objects with antimicrobial action.