“…This paper has shown that the cytotoxicity of plants that downregulate the anti-apopototic genes such as Bax/Bcl2 (apoptosis inducing genes) that promote cell death, like in Artocarpus obtusus [50], rise in Bax/Bcl2 ratio to induce apoptotic pathway like in Dillena suffruticosa [74] also in Z. offinalis [48], Juglans regia [47], L. pumila [75] and T. foenum [76] and on the other hand, the use of pro-apopotic genes like caspases, 3, 7, 8 and 9, and P53 has make a clear expression in in Artocarpus obtusus [50], C. sativum [95], G. macrophyllus [91], Persea declinata [80], P. minima [96], Sandoricum koetjape [89], T. foenum [94], S. wallichii [38], and Brassica oleracea [97]. Apoptosis and cell proliferation were the major biological pathway in cell death, and plant with highest apoptosis were A. sativum [33,60], C. sativum [98], Anisochilus carnosus, P. minima [52,96], Sandoricum koetjape [89], E. cottonii [43], C. xanthorrhiza [40], Nigella sativa [99], R. rosea [94], Sanchezia speciosa [100], and Ipomoea quamoclit [101], and those with least apoptosis were Phyla nodiflora [102], Brassica olorecea [97], Murraya koenigii [42], and Hydnophytum formicarum [103] while those plant that shows apoptosis with morphological changes includes E. longifolia [85], S. ferruginea [104], Syzygium aromaticum [63], C. longa [33,37], A. precatorius [59]...…”