Anterior Pituitary

Daughaday, William H.

doi:10.1007/978-1-4757-4857-4_2

Cited by 14 publications

(26 citation statements)

References 148 publications

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“…dp<0.01. changes within the sella so that accurate delineation of tumor margins may become difficult (10). But neither a tumor shrinkage nor a further progression in tumor growth could be observed, even in the six patients treated with bromocriptine only (primary bromocriptine treated patients) (patients 2,4,7,9,10,12).…”

Section: Resultsmentioning

confidence: 96%

Bromocriptine treatment over 12 years in acromegaly: effect on growth hormone and prolactin secretion

Rau

Althoff²,

Schmidt³

et al. 1992

Acta Endocrinologica

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Bromocriptine treatment over 12 years in acromegaly: effect on growth hormone and prolactin secretion. Acta Endocrinol 1992;126:247-52. ISSN 0001-5598 It is not known whether bromocriptine treatment in acromegaly can be implemented for a life-long period. To elucidate this problem, the secretory GH and PRL states of 12 patients with acromegaly were determined, before bromocriptine treatment, under therapy (15.0\m=+-\6.8mg/day for 12\m=+-\3 years; mean\m=+-\sd) and during two-weeks long drug withdrawal after long-term treatment, respectively. Before therapy, all patients showed'a non-sufficient GH suppression after oral glucose load (>2 \g=m\g/l), whereas under dopaminergic treatment the post-glucose GH levels of three patients fell below 2 \g=m\g/l; normal IGF-I concentrations were found in five patients. However, under bromocriptine, only two patients showed GH suppressions below 2 \g=m\g/lfollowing glucose, accompanied with normal IGF-I levels. During bromocriptine withdrawal, GH secretion at 60 min in the oral glucose tolerance test increased significantly (17.0\m=+-\15.5 vs 5.7\m=+-\5.2 \g=m\g/l;p<0.01); the mean IGF-I level rose from 2.1 \m=+-\0.8to 4.9 \ m=+-\ 2.2 kU/l (p <0.01). IGF-I was normal during bromocriptine cessation in only one patient; none of the 12 patients showed a GH suppression below 2 \g=m\g/lafter oral glucose load. Under dopaminergic treatment hyperprolactinemia could not be detected. In conclusion, bromocriptine led to a stable suppression of both GH hypersecretion and\p=m-\if present\p=m-\concomitantlyelevated PRL levels. Severe side effects or a further tumor growth could not be observed. Thus, the data of the longest follow-up investigation that has so far been published indicate that effective life-long bromocriptine therapy seems to be possible in selected patients with acromegaly.Since 1974, when Liuzzi et al. observed the suppressive effect of bromocriptine on elevated GH levels in patients with acromegaly ( 1 ), this dopaminergic drug has been widely used for the treatment of GH secreting tumors (2. 3).It is not known whether the effectiveness of bromo¬ criptine treatment in acromegaly is limited by a certain duration of dopaminergic therapy. Recently, our study group reported on the effects of a two-week long bromocriptine withdrawal on body composition and clinical well-being in dopaminergic long-term treated acromegaly patients (4). Now, based on the same study, an evaluation is presented referring to the effectiveness of long-term bromocriptine treatment (15.0 ±6.8 mg/ day for 12 ± 3 years) and a following bromocriptine withdrawal for two weeks in 12 patients with acro¬ megaly on GH and PRL secretion.Our main interest concerned the possibility of a stable suppression of both GH hypersécrétion and-if pres¬ ent-concomitant elevated PRL levels under dopami¬ nergic treatment over a mean period of 12 years. Possible changes in tumor size would be investigated during bromocriptine long-term treatment and we wanted to determine any predictive factors for a success¬ ful outcome of b...

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Section: Resultsmentioning

confidence: 96%

Bromocriptine treatment over 12 years in acromegaly: effect on growth hormone and prolactin secretion

Rau

Althoff²,

Schmidt³

et al. 1992

Acta Endocrinologica

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“…Prolactin is unique among the anterior pituitary hormones because its secretion is affected by a large variety of stimuli called PRL-releasing factors, such as thyrotropin-releasing hormone, oxytocin, and neurotensin; the most important psychological stimuli that elevate pituitary PRL secretion are suckling stress in women and psychological stress in men (23). In mammals the control exerted by the hypothalamus over pituitary PRL secretion is largely inhibitory.…”

Section: Discussionmentioning

confidence: 99%

Mucuna pruriens improves male fertility by its action on the hypothalamus–pituitary–gonadal axis

Shukla

Mahdi

Ahmad

et al. 2009

Fertility and Sterility

105

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“…Furthermore, there are physiological states that can be adequately explained by extrahypothalamic regulation of neuron activity. These include, for instance, suckling-induced amenorrhea (c.f., 13) and stress-induced amenorrhea (c.f., 20,21). Each of these phenomena may be mediated by neuronal networks that utilize neurotransmitters, such as noradrenaline, acetylcholine, and histamine, implicated in the control of LHRH release (c.f., 13,20).…”

Section: Control and Preexamination Lh And Testosterone Plasma Valumentioning

confidence: 99%

Examination stress decreases plasma level of luteinizing hormone in male students.

Johansson

Laakso

Peder

et al. 1988

Psychosomatic Medicine

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Plasma levels of luteinizing hormone (LH) and testosterone were determined by radioimmunoassay in medical students just before (Exp. 1) and after (Exp. 2) an academic examination and corresponding control periods. Before the examination (Exp. 1), the males' LH values were lower than their control levels, but there was no such difference in the females. Testosterone levels were unaffected in both sexes. There was no correlation between the values of LH and testosterone. There was, however, a significant negative correlation in the males, and an almost significant negative correlation in the females, between the preexamination testosterone values and the examination scores achieved. After the examination (Exp. 2), again the LH values were lower than the control values in the males, but not in the females, and the testosterone values were unaffected in both sexes. There was a weak positive correlation between the postexamination LH and testosterone values in the males, but not in the females. The results are in line with earlier observations suggesting that psychological stress is associated with different hormonal effects in males and females.

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Anterior Pituitary

Cited by 14 publications

References 148 publications

Bromocriptine treatment over 12 years in acromegaly: effect on growth hormone and prolactin secretion

Bromocriptine treatment over 12 years in acromegaly: effect on growth hormone and prolactin secretion

Mucuna pruriens improves male fertility by its action on the hypothalamus–pituitary–gonadal axis

Examination stress decreases plasma level of luteinizing hormone in male students.

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