Mucuna pruriens improves male fertility by its action on the hypothalamus–pituitary–gonadal axis

Shukla, Kamla Kant; Mahdi, Abbas Ali; Ahmad, Mohammad Kaleem; Shankhwar, Satya Narain; Rajender, Singh; Jaiswar, Shyam Pyari

doi:10.1016/j.fertnstert.2008.09.045

Cited by 100 publications

(64 citation statements)

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“…Sperm count and motility were significantly recovered in infertile men after treatment. (Shukla KK, et al 2009) [43] Asparagus racemosus:-The hydro-alcoholic extract of Asparagus racemosus (Satavari) root at concentration of 400 mg/kg body weight showed significant aphrodisiac activity on male wistar albino rats as evidenced by an increase in number of mounts and mating performance. In the same study, hydroalcoholic extract at lower dose (200 mg/kg.…”

Section: (Suresh S Et Al 2009) [42]mentioning

confidence: 99%

Vrishya and Vajikarana - Exploring Ancient Science of Aphrodisiacs

Chaudhary¹,

Lamba²,

Mehra³

2017

J Res Educ Indian Med - ISSN 0970-7700

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Introduction:Vajikarana is one of the eight specialities of Ashtang Ayurveda dealing with the management of pathophysiology of spermatogenesis and healthy sexual potentiation. This aphrodisiac therapy is advocated for various sexual and reproductive disease i.e., Klaibya or Erectile dysfunctions, Bandhyatva or Infertility, Shukraghata Vata or azospermia and premature ejaculation. Vrishya, a synonym of Vajikara, is the technical term indicating spermatogenic and aphrodisiac effect of a dravya (foods, herbs, spices and Medicinal plants) including audio-visual, socio-religious effects/ sexual behaviour factors/ constants). Currently, the importance of this branch has increased manifold, as more and more people are reporting to clinics with various disorders related to seminal parameters and sexual dysfunction. Material and Methods: Various drugs mentioned under these therapies were searched including scientific data pertaining to their efficacy and probable mode of action. The search was limited to Ayurveda classics, books and published works from pubmed as well as non-pubmed indexed journals including google scholar database. The present review is mainly focussed on brihatryi (Charaka Samhita, Sushruta Samhita and Ashtang) for elaborate understanding of the concept of Vrishya and Vajikarana. The texts Sarangdhar Samhita and Bhavprakash Nighantu were searched for the drugs indicated as vrishya and vajikarana properties. Results: Analyses of the textual data revealed that Vrishya dravyas act as Vajikara also, but all Vajikara dravyas do not possess Vrishya property. This appears due to predominance of stimulant action on Sukravaha Samsthana in Vajikara dravyas while Vrishya has mainly quantitative and qualitative effect on Sukra. These drugs also act on higher centres of the brain which helps to alleviate anxiety associated with sexual performance as revealed by the published scientific data. Aphrodiasics also modulate the level of the pituitary hormones FSH and LH. The drugs possessing these properties have been tabulated in the text. Conclusion: Vajikarana is the therapy while Vrishya is the property (Karma) of the drug. Vrishya drugs are successful in treating conditions of reproductive disorders and sexual performance and they have an effect on pituitary-gonadal axis. Investigations in validation of these drugs will go a long way in management of infertility.

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Section: (Suresh S Et Al 2009) [42]mentioning

confidence: 99%

Vrishya and Vajikarana - Exploring Ancient Science of Aphrodisiacs

Chaudhary¹,

Lamba²,

Mehra³

2017

J Res Educ Indian Med - ISSN 0970-7700

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“…These include but are not limited to: astragalus root (Astragalus membranaceus) [32][33][34], Chinese yam [35], Greek hay (fenugreek seed extract) [36], barrenwort (herba epimedium) [37], Longjack root (eurycoma longifolia) [38,39], passionflower extract (passiflora incarnate) [22,40], velvet bean extract (mucuna pruriens) [41][42][43], ginkgo biloba [44,45], ginseng [46,47], and tribulus terrestris [17,24,48]. Several of these ingredients have been studied in great detail with regards to impacting testosterone and GH concentrations, while others have only scant research investigating their efficacy.…”

Section: Overview Of Herbal Dietary Supplementsmentioning

confidence: 99%

“…We are presently completing a study in our lab involving DAA supplementation, which should provide additional evidence for or against the use of this amino acid for purposes of testosterone elevation. [41][42][43], ginkgo biloba [44,45], ginseng [46,47], passionflower extract (passiflora incarnate) [22,40,101], Longjack root (eurycoma longifolia) [38,39,102], and tribulus terrestris [17,24,48] are all touted to have health benefits and to increase testosterone levels. Of these, Longjack root and tribulus terrestris are of particular interest in the research community and will be explored in greater detail throughout the remainder of this review.…”

Section: Nutrient Intakementioning

confidence: 99%

“…A limited number of animal studies have found that TT significantly increases testosterone levels. For example, two of three recent studies utilizing Wistar rats found serum testosterone levels to be significantly increased following varying dosages of TT taken once daily [42,123,124]. Martino-Andrale et al found no significant increase in serum testosterone levels but supplemented the wistar rats with the lowest level of TT between the three studies [124], suggesting that dosing is a factor in achieving desired outcomes.…”

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Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

Gunnels¹

2014

J Plant Biochem Physiol

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Low circulating testosterone levels can present numerous problems related to the overall health and well-being of individuals, men in particular. This finding is well-documented in the literature and low testosterone appears more prevalent in older men, in particular those who are physically inactive and who present with elevated levels of body fat. Multiple botanical (herbal) products have been claimed to elevate circulating testosterone in men; however, data pertaining to the use of such herbal preparations obtained from human clinical trials are limited. This review examines the research to date pertaining to the use of herbal ingredients with regards to their ability to elevate blood testosterone levels. A collective summary of the findings indicate that certain herbal supplements may actually yield an increase in testosterone (e.g., Longjack root), while most others have little to no evidence in support of their use in human subjects. Additional, well-controlled clinical trials are needed to generate data relative to the use of herbal dietary supplements to increase circulating testosterone. Testosterone is generally measured as either "free" (unbound) or "total" (unbound and chemically bound). Men who have a morning serum testosterone level < 300 ng/dL are considered to be "low" and may be a candidate for testosterone replacement therapy-which has become more common in recent years due to the increased diagnosis of andropause [55]. Insufficient levels of testosterone due to either impaired production or uptake can present serious health consequences due to the wide array of applications of testosterone within the human body. Areas including skeletal muscle health, muscular strength, and overall well-being/vitality seem to be significantly affected by testosterone status. Increasing Circulating Testosterone: Impact of Herbal Dietary SupplementsTrintThe role of testosterone in muscle growth has been investigated extensively in both humans and animals [56][57][58][59][60][61][62]. One study in men concluded that the testosterone-induced increase in muscle volume is due to muscle fiber hypertrophy [63]. A follow-up study conducted a year later noted muscle hypertrophy in men over a period of 20 weeks of treatment with a gonadotropin-releasing hormone agonist and a 125-, 300-, or 600-mg weekly dose of testosterone enanthate. The main findings from this study indicated that testosterone administration was associated with a significant increase in myonuclear number in men receiving the 300-and 600-mg doses.Muscular strength is another important factor that has been shown to be affected by testosterone levels in the body [56,61,62,[64][65][66]. A recent investigation utilized 267 men with stages 2-4 of Chronic Kidney Disease to assess the impact of testosterone level on a variety of variables [64]. This study found that testosterone was significantly and independently associated with handgrip strength, muscle mass, and nutritional status as the disease progressed. Another study explored short-term testoste...

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“…According to Sukhla, koro benguk can increase spem quality [3], repairing semen profile, seminal plasma biochemical parameters [4], and increase male fertility [5]. Separately in Indonesia's region, especially in Wonogiri, Central Java, koro benguk is processed as tempeh benguk's ingredient, and in some UMKM-Usaha Mikro, Kecil dan Menengah (Small and Medium Enterprises) is processed as tempeh benguk chips.…”

Section: Introductionmentioning

confidence: 99%

The Processing Model in Making Tempeh Benguk [Mucuna pruriens (L.) DC] Containing High L-Dopa

Winarni¹,

Dharmawan²

2017

KLS

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Abstract"Koro benguk" [Mucuna pruriens (L.) DC] seed contains L-dopa which is able to repair spermatozoa quality. The aim of this experiment is to analyze L-Dopa using HPLC in engineering manufacture of tempeh benguk. There are four engineering model's variants of making tempeh benguk. The engineering process begins with selection of koro benguk seed, tools required, immersion, boiling, humidity, temperature and pH. The result shows that the process in making tempeh benguk which contains the highest concentration of L-Dopa (11 346.85 mg ⋅ kg −1 ) is white-colored and intact koro benguk seed; one time immersion with replacing the water for 4 to 5 times/day (two days and two nights); one time boiling (< 1 h until koro benguk seed can be opened); mixed with 10 mL lime juice/1.5 kg, with concentration of 0.83% until pH 5, added with mashed teak leaves, and ended with the process of making tempeh benguk at room temperature (30 ∘ CC), relative humidity room (65%). Tempeh benguk which is produced is cleaner, whiter, nonperishable, and more tender.

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Mucuna pruriens improves male fertility by its action on the hypothalamus–pituitary–gonadal axis

Cited by 100 publications

References 24 publications

Vrishya and Vajikarana - Exploring Ancient Science of Aphrodisiacs

Vrishya and Vajikarana - Exploring Ancient Science of Aphrodisiacs

Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

The Processing Model in Making Tempeh Benguk [Mucuna pruriens (L.) DC] Containing High L-Dopa

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