Anterior capsule opacification

Werner, Liliana; Pandey, Suresh K; Apple, David J.; Escobar-Gómez, Marcela; McLendon, Lucia; Macky, Tamer A.

doi:10.1016/s0161-6420(01)00674-1

Cited by 132 publications

(40 citation statements)

References 34 publications

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“…The LEC proliferation process is regulated by various cytokines and growth factors, such as IL-1, IL-6, transforming growth factor (TGF) and fibroblast growth factor (FGF), which are secreted by residual LECs and inflammatory cells424344. Hydrophobic IOL has a higher incidence rate of ACO than hydrophilic IOL, because hydrophobic surfaces tend to attract more remnant LECs and inflammatory cells to adhere and proliferate5645. Our results showed that surface modification by P(MPC-MAA) significantly suppressed ACO formation, which could be a direct consequence of decreased LECs adhesion and proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…Six weeks after surgery, ACO was scored from grade 0 to IV based on the severity of the anterior capsule opacity and the contraction of the anterior capsulorhexis opening: Grade 0: clear (transparent) anterior capsule; Grade I: opacification localized at the edge of the capsulorhexis; Grade II: moderate and diffuse opacification, in some cases with areas of capsular folding; Grade III: intense opacification, with areas of capsular folding; Grade IV: constriction (phimosis) of the capsulorhexis opening45.…”

Section: Methodsmentioning

confidence: 99%

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Improvement of Uveal and Capsular Biocompatibility of Hydrophobic Acrylic Intraocular Lens by Surface Grafting with 2-Methacryloyloxyethyl Phosphorylcholine-Methacrylic Acid Copolymer

Tan

Zhan

Cao

et al. 2017

Sci Rep

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Biocompatibility of intraocular lens (IOL) is critical to vision reconstruction after cataract surgery. Foldable hydrophobic acrylic IOL is vulnerable to the adhesion of extracellular matrix proteins and cells, leading to increased incidence of postoperative inflammation and capsule opacification. To increase IOL biocompatibility, we synthesized a hydrophilic copolymer P(MPC-MAA) and grafted the copolymer onto the surface of IOL through air plasma treatment. X-ray photoelectron spectroscopy, atomic force microscopy and static water contact angle were used to characterize chemical changes, topography and hydrophilicity of the IOL surface, respectively. Quartz crystal microbalance with dissipation (QCM-D) showed that P(MPC-MAA) modified IOLs were resistant to protein adsorption. Moreover, P(MPC-MAA) modification inhibited adhesion and proliferation of lens epithelial cells (LECs) in vitro. To analyze uveal and capsular biocompatibility in vivo, we implanted the P(MPC-MAA) modified IOLs into rabbits after phacoemulsification. P(MPC-MAA) modification significantly reduced postoperative inflammation and anterior capsule opacification (ACO), and did not affect posterior capsule opacification (PCO). Collectively, our study suggests that surface modification by P(MPC-MAA) can significantly improve uveal and capsular biocompatibility of hydrophobic acrylic IOL, which could potentially benefit patients with blood-aqueous barrier damage.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Improvement of Uveal and Capsular Biocompatibility of Hydrophobic Acrylic Intraocular Lens by Surface Grafting with 2-Methacryloyloxyethyl Phosphorylcholine-Methacrylic Acid Copolymer

Tan

Zhan

Cao

et al. 2017

Sci Rep

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“…Although hydrophilic acrylic IOLs with square-edge design and four haptics are expected to have enhanced uveal biocompatibility and capsular support [3, 13, 14], a few cases of anterior capsular phimosis after implantation of these IOLs were reported [4, 5, 15]. Notably, most of the cases were associated with pseudoexfoliation syndrome [4, 5].…”

Section: Discussionmentioning

confidence: 99%

Postoperative occlusion of visual axis with fibrous membrane in the presence of anterior capsular phimosis in a patient with pseudoexfoliation syndrome: a case report

Kim

Lee

et al. 2016

BMC Ophthalmol

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BackgroundTo report a case of postoperative fibrous membrane formation occluding the visual axis in the presence of anterior capsular phimosis in a patient with pseudoexfoliation syndrome.Case presentationA 79-year-old Asian woman with pseudoexfoliation syndrome underwent uneventful phacoemulsification and implantation of one-piece hydrophilic acrylic square-edged intraocular lens (Cristalens) in the right eye. Two months later, she had blurred vision in the right eye with the best-corrected visual acuity (BCVA) of 20/40. Formation of fibrous membrane occluding the capsulorhexis opening with contraction of anterior capsule was observed, which was confirmed by anterior segment optical coherence tomography. Clear visual axis was achieved by lysis of the membrane using Nd:YAG laser. The BCVA improved to 20/20.ConclusionsOcclusion of the visual axis with fibrous membrane can develop in the presence of anterior capsular phimosis in a patient with pseudoexfoliation syndrome.

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“…The extent and severity of ACO and PCO were scored according to methods established at our laboratory. 17,18 After gross examination and photographs, all globes were sectioned and the anterior segments including the capsular bags were processed for standard light microscopy and stained with hematoxylin-eosin.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of uveal and capsule biocompatibility of a single-piece hydrophobic acrylic intraocular lens with ultraviolet–ozone treatment on the posterior surface

Farukhi

Werner

Kohl

et al. 2015

Journal of Cataract and Refractive Surgery

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Anterior capsule opacification

Cited by 132 publications

References 34 publications

Improvement of Uveal and Capsular Biocompatibility of Hydrophobic Acrylic Intraocular Lens by Surface Grafting with 2-Methacryloyloxyethyl Phosphorylcholine-Methacrylic Acid Copolymer

Improvement of Uveal and Capsular Biocompatibility of Hydrophobic Acrylic Intraocular Lens by Surface Grafting with 2-Methacryloyloxyethyl Phosphorylcholine-Methacrylic Acid Copolymer

Postoperative occlusion of visual axis with fibrous membrane in the presence of anterior capsular phimosis in a patient with pseudoexfoliation syndrome: a case report

Evaluation of uveal and capsule biocompatibility of a single-piece hydrophobic acrylic intraocular lens with ultraviolet–ozone treatment on the posterior surface

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