Improvement of Uveal and Capsular Biocompatibility of Hydrophobic Acrylic Intraocular Lens by Surface Grafting with 2-Methacryloyloxyethyl Phosphorylcholine-Methacrylic Acid Copolymer

Abstract

Biocompatibility of intraocular lens (IOL) is critical to vision reconstruction after cataract surgery. Foldable hydrophobic acrylic IOL is vulnerable to the adhesion of extracellular matrix proteins and cells, leading to increased incidence of postoperative inflammation and capsule opacification. To increase IOL biocompatibility, we synthesized a hydrophilic copolymer P(MPC-MAA) and grafted the copolymer onto the surface of IOL through air plasma treatment. X-ray photoelectron spectroscopy, atomic force microscopy and static water contact angle were used to characterize chemical changes, topography and hydrophilicity of the IOL surface, respectively. Quartz crystal microbalance with dissipation (QCM-D) showed that P(MPC-MAA) modified IOLs were resistant to protein adsorption. Moreover, P(MPC-MAA) modification inhibited adhesion and proliferation of lens epithelial cells (LECs) in vitro. To analyze uveal and capsular biocompatibility in vivo, we implanted the P(MPC-MAA) modified IOLs into rabbits after phacoemulsification. P(MPC-MAA) modification significantly reduced postoperative inflammation and anterior capsule opacification (ACO), and did not affect posterior capsule opacification (PCO). Collectively, our study suggests that surface modification by P(MPC-MAA) can significantly improve uveal and capsular biocompatibility of hydrophobic acrylic IOL, which could potentially benefit patients with blood-aqueous barrier damage.

Micropatterned immobilization of membrane-mimicking polymer and peptides for regulation of cell behaviorsin vitro

“…Chemical shi of protons of methylene and methyl group which were marked with e and f was about 1.3 and 1.8 ppm. The appearances of chemical shi a, b and c at about 2.8, 1.8 and 1.0 ppm, are also in consistent with the reported results 35,36 and demonstrated that HD was graed to the polymer PMMPC because of the existence of the proton of methylene in the PMMPC-HD which was ascribed to the HD.…”

Comparison between flipped classroom and lecture-based classroom in ophthalmology clerkship

“…The global trend in population aging calls for an increased number of well-trained ophthalmologists to provide eye care to the elderly, who commonly suffer from ophthalmic disorders, including cataract (and intraocular lens-related problems), age-related macular degeneration (AMD), and diabetes retinopathy [1–5]. Ophthalmic education is essential not only for the training of future ophthalmologists, but also for medical practitioners from other disciplines in general, as visual system dysfunction may provide clues for the diagnosis of systemic diseases [6,7].…”

Killing two birds with one stone: dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacification

“… 8 Studies from our group and others have reported that hydrophilic surface modification of IOLs can significantly increase protein and cell repellence, thus preventing ACO. 9 , 10 On the other hand, PCO can be suppressed through blocking the migration and proliferation of LECs, which can be achieved by applying cytotoxic drugs or sharpening the optic edge of the IOLs. 11 However, preventative approaches of ACO and PCO are contradictory.…”