Evaluation of uveal and capsule biocompatibility of a single-piece hydrophobic acrylic intraocular lens with ultraviolet–ozone treatment on the posterior surface

Farukhi, M. Aabid; Werner, Liliana; Kohl, Justin C.; Gardiner, Gareth; Ford, Joshua; Cole, Scott C.; Vasavada, Shail; Noristani, Rozina; Mamalis, Nick

doi:10.1016/j.jcrs.2014.11.043

Cited by 9 publications

(2 citation statements)

References 26 publications

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“…Additionally, UV/O 3 treatment causes little damage to the IOL surface, whereas argon plasma may promote surface deterioration through an etching effect. Farukhi et al [ 55 ] used UV/O 3 treatment to modify the posterior surface of IOLs, which achieved similar PCO prevention effects in in vivo animal experiments.…”

Section: The Main Types Of Iols Used For Pco Prophylaxismentioning

confidence: 99%

Research Progress Concerning a Novel Intraocular Lens for the Prevention of Posterior Capsular Opacification

Zhang

Zhang²,

Chen³

et al. 2022

Pharmaceutics

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Posterior capsular opacification (PCO) is the most common complication resulting from cataract surgery and limits the long-term postoperative visual outcome. Using Nd:YAG laser-assisted posterior capsulotomy for the clinical treatment of symptomatic PCO increases the risks of complications, such as glaucoma, retinal diseases, uveitis, and intraocular lens (IOL) pitting. Therefore, finding how to prevent PCO development is the subject of active investigations. As a replacement organ, the IOL is implanted into the lens capsule after cataract surgery, but it is also associated with the occurrence of PCO. Using IOL as a medium for PCO prophylaxis is a more facile and efficient method that has demonstrated various clinical application prospects. Thus, scientists have conducted a lot of research on new intraocular lens fabrication methods, such as optimizing IOL materials and design, and IOL surface modification (including plasma/ultraviolet/ozone treatment, chemical grafting, drug loading, coating modification, and layer-by-layer self-assembly methods). This paper summarizes the research progress for different types of intraocular lenses prepared by different surface modifications, including anti-biofouling IOLs, enhanced-adhesion IOLs, micro-patterned IOLs, photothermal IOLs, photodynamic IOLs, and drug-loading IOLs. These modified intraocular lenses inhibit PCO development by reducing the residual intraoperative lens epithelial cells or by regulating the cellular behavior of lens epithelial cells. In the future, more works are needed to improve the biosecurity and therapeutic efficacy of these modified IOLs.

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Section: The Main Types Of Iols Used For Pco Prophylaxismentioning

confidence: 99%

Research Progress Concerning a Novel Intraocular Lens for the Prevention of Posterior Capsular Opacification

Zhang

Zhang²,

Chen³

et al. 2022

Pharmaceutics

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“…According to the "no space, no cells" theory, timely capsular bend formation can effectively prevent PCO. [21][22][23][24] Although anterior capsule polishing reduces fibrotic opacification, it may be less effective in reducing regenerative opacification. 2,25 Therefore, this self-controlled study was conducted to explore the effects of anterior capsule polishing on capsule-IOL complex healing and postoperative capsule opacification.…”

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confidence: 99%

Impact of anterior capsule polishing on capsule opacification and capsule bend after age-related cataract surgery

Huang,

Tong,

Wang

et al. 2024

J Cataract Refract Surg

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Purpose: To investigate the effect of anterior capsule polishing on postoperative capsule opacification and capsular bend in patients with age-related cataract displaying normal axial length. Setting: University hospital. Design: Prospective self-controlled trial. Methods: Patients with age-related cataracts aged 56 to 84 years displaying normal axial length were enrolled. Prior to surgery, a coin-toss method was used to randomly select one eye for intraoperative 360° anterior capsule polishing (polishing group); the contralateral eye received no treatment (control group). Capsular bend index (CBI), anterior capsule opacification (ACO), posterior capsule opacification (PCO), and anterior capsule opening area (ACOA) were recorded at 1 week, 1 month, 3 months, 6 months, and 12 months postoperatively using swept-source optical coherence tomography and slit-lamp examination. Results: Twenty-one patients (42 eyes) were enrolled. Within-group comparisons showed that both groups had significant differences in CBI between 1 week and 1 month postoperatively, and between 6 months and 12 months postoperatively (P < .05). Between-group comparisons revealed a significant difference in CBI at 1 week postoperatively (P < .05); at 12 months postoperatively, there was a significant difference in ACOA (P < .05). There were no significant between-group differences regarding ACO or PCO at any time point (P > .05). Conclusions: For patients with age-related cataracts and normal axial length, 360° anterior capsule polishing can delay early capsular bag deformation without increasing the risks of ACO and PCO. This approach can also limit contraction of the anterior capsule opening.

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Design, Material, Insertion, and Pathophysiology of IOLs

Werner

2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Evaluation of uveal and capsule biocompatibility of a single-piece hydrophobic acrylic intraocular lens with ultraviolet–ozone treatment on the posterior surface

Cited by 9 publications

References 26 publications

Research Progress Concerning a Novel Intraocular Lens for the Prevention of Posterior Capsular Opacification

Research Progress Concerning a Novel Intraocular Lens for the Prevention of Posterior Capsular Opacification

Impact of anterior capsule polishing on capsule opacification and capsule bend after age-related cataract surgery

Design, Material, Insertion, and Pathophysiology of IOLs

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