Antenatal Diagnosis of a Large Immature Abdominal Wall Teratoma by 2D-3D Ultrasound Using HDlive and Magnetic Resonance Imaging

Werner, Heron; Mocarzel, Carolina Carvalho; Sá, Renato Augusto Moreira de; Tonni, Gabriele; Novoa, Victoria Arruga Novoa y; Avvad-Portari, Elyzabeth; Bonasoni, Maria Paola; Júnior, Edward Araujo

doi:10.1080/15513815.2016.1214199

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Arisoy et al (11) found that ultrasonography has very high sensitivity (100%) and low false-positive (3.3%) rates in the prenatal identification of teratoma, and its specificity rate (96.7%) and positive predictive value (83.3%) are also high. Italian researchers indicated that 3D ultrasound may enhance characterization of the tumor tissues especially if combined with HDlive application (17). Werner et al (18) have demonstrated that 3D ultrasound and MRI volumes can be used to produce 3D virtual physical models of different types of congenital anomalies; in particular, it can be applied for diagnosis of giant cervical teratoma or congenital neck tumors.…”

Section: Discussionmentioning

confidence: 99%

“…( 11 ) found that ultrasonography has very high sensitivity (100%) and low false-positive (3.3%) rates in the prenatal identification of teratoma, and its specificity rate (96.7%) and positive predictive value (83.3%) are also high. Italian researchers indicated that 3D ultrasound may enhance characterization of the tumor tissues especially if combined with HDlive application ( 17 ). Werner et al.…”

Section: Discussionmentioning

confidence: 99%

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Case report: Fetal cervical immature teratoma and copy number variations

Guo

Zheng

et al. 2022

Front. Oncol.

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Fetal cervical teratoma is a rare congenital neck tumor. Here, we report a case of a fetus with an anterior solid neck tumor that was confirmed to have an immature teratoma by histology. A duplication was found at chromosome 14q24.1-q24.3 of the fetus in chromosome microarray (CMA) and whole exome sequencing (WES), which was a copy number variation (CNV) and a probably new-onset. Ultrasound coupled with magnetic resonance imaging (MRI) can be considered to be a relatively reliable diagnostic tool, whereas ex-utero intrapartum therapy or resection of the tumor mass on placental support may improve the chances of the newborn’s survival. Strangely, the same duplication occurred on her next fetus that was found with complex congenital heart malformations. CNV at chromosome 14q24.1-q24.3 needs to be paid more attention.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Case report: Fetal cervical immature teratoma and copy number variations

Guo

Zheng

et al. 2022

Front. Oncol.

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“…If the diameter is ≥ 10 cm, the possibility of a malignant transforma-tion should be considered [1] . A B-mode ultrasound is the first choice for monitoring a teratoma [9] ; therefore, when a B-mode ultrasound finds a giant pelvic mass, heterogeneous solid components in the cystic wall, cystic wall involvement, and adhesion of the tumor tissue to the surrounding tissues, the possibility of a malignant transformation should be highly considered. A mature teratoma has complex ultrasonic manifestations, and it has a common characteristic "lack of blood flow" signal.…”

Section: Discussionmentioning

confidence: 99%

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Zhou

Jin

et al. 2018

Clin Surg Res Commun

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A mature ovarian teratoma is a common benign germ cell tumor of the ovary in women that rarely causes a malignant transformation. However, a malignant transformation can occur in the ectodermal, mesodermal, and endodermal tissues of the tumor. A squamous cell carcinoma is the most common and an adenocarcinoma is the second most common malignant tumor derived from a cystic teratoma. Due to the rarity of malignant transformations in mature teratomas and the lack of clinical data, the clinical pathological features, malignant transformation mechanism, therapeutic methods, and prognosis-relevant factors are unclear. Currently, there is no specific diagnostic method, and it is a difficult lesion to diagnose before performing surgery. In order to improve clinicians' understanding of a malignant-transformed mature teratoma and identification of malignant-transformed teratomas at early stages, we have reported a case of a mature teratoma with the malignant transformation of a sebaceous gland carcinoma in the Yiwu Central Hospital in Zhejiang, China on May 31, 2018. A review of the literature is also presented to summarize the clinical symptoms, pathogenesis, diagnosis, and treatment of malignant-transformed mature teratomas.

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MiR-449b inhibits the migration and invasion of colorectal cancer cells through the negative regulation of MMP2

Zhang

2018

Clin Surg Res Commun

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Background: An increasing number of miRNAs were confirmed to be involved in the initiation and progression of colorectal cancer (CRC) by acting as cancer suppressor genes and oncogenes. The purpose of this study was to uncover the role of miR-449b in CRC and its underlying mechanisms. Methods: The expression profile of miR-449b in human CRC tissues and cell lines was determined using quantitative real-time polymerase chain reaction (qRT-PCR) analysis. The effect of miR-449b on CRC was assessed by CRC cell migration and invasion as determined using a transwell assay. A luciferase reporter assay was also carried out to explore the interaction between MMP2 3′UTR and miR-449b. Results: The current study revealed that the relative expression of miR-449b was decreased significantly in human CRC tissues and cell lines; meanwhile, miR-449b in metastatic CRC tissues was significantly lower than that in non-metastatic CRC tissues. We also observed that the forced miR-449b in CRC cells significantly restrained cell migration and invasion in vitro. In contrast to miR-449b, our study found that both the MMP-2 mRNA and protein levels were increased in CRC cells. MiR-449b negatively regulated MMP2 in CRC cells, and the result was corroborated by luciferase reporter assay. Most importantly, overexpression of MMP2 significantly reversed the miR-449b-mediated inhibition on the invasion and migration of CRC cells. Conclusion: Our data provided encouraging evidence that miR-449b possessed a strong inhibitory effect on CRC cell migration and invasion by negative regulation of MMP2.

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Antenatal Diagnosis of a Large Immature Abdominal Wall Teratoma by 2D-3D Ultrasound Using HDlive and Magnetic Resonance Imaging

Cited by 3 publications

References 20 publications

Case report: Fetal cervical immature teratoma and copy number variations

Case report: Fetal cervical immature teratoma and copy number variations

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

MiR-449b inhibits the migration and invasion of colorectal cancer cells through the negative regulation of MMP2

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