Antenatal Dexamethasone and Decreased Severity of Retinopathy of Prematurity

Higgins, Rosemary D.; Mendelsohn, Alan L.; DeFeo, Michael J.; Üçsel, Raif; Hendricks‐Muñoz, Karen D.

doi:10.1001/archopht.116.5.601

Cited by 97 publications

(58 citation statements)

References 17 publications

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“…Study done by Purohit et al [23] found PIH to be signifi cant risk factor; which was found to be signifi cant in our study as well. Premature rupture of membrane had no effect on ROP causation; as was also seen by Higgins et al [25] …”

Section: Figure 1bsupporting

confidence: 69%

Retinopathy of prematurity in babies weighing <1800 g; with special reference to babies weighing between 1501 and 1800 g: An experience from a tertiary care hospital in Delhi

Kapoor

Talwar

Sachdeva

et al. 2014

Int J Med Public Health

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Background: Retinopathy of prematurity (ROP) is a disease related to low birth weight, prematurity, oxygen administration, and various other factors, which are yet to be identifi ed. Aims: The aim was to fi nd incidence of ROP and risk factors for causation in babies weighing <1800 g; and in the babies weighing between 1501 and 1800 g. Design: Prospective study. Materials and Methods: Neonates weighing ≤1800 g taking birth in our institution from January 2011 to January 2012 for a span of 1 year; were included in the study. The data were analyzed to determine risk factors for ROP causation. Information was collected using the standardized performa which included the maternal risk factors as well. Infants were classifi ed by ophthalmologic examination fi ndings using ICROP revisited. Statistics: Qualitative data were analyzed using Pearson's Chi-square test with Yates correction or Fisher's exact test and possible risk factors were analyzed by univariate analysis and multivariate analysis. Results: A total of 278 subjects was included in the study. Incidence of ROP in babies ≤1800 g was found to be 13.67% (38/278). Incidence of ROP in babies weighing between 1501 and 1800 g was 11.64% (17/146). Twenty-one risk factors were signifi cant on univariate analysis in babies weighing ≤1800 g and 18 risk factors in the babies weighing between 1501 and 1800 g. Multiple gestations (P < 0.01), blood transfusion (P < 0.01), antepartum hemorrhage (P < 0.01), pregnancy-induced hypertension (P < 0.01), mechanical ventilation (MV) (P < 0.01), and APGAR at 1 min (P < 0.01) were found to be independently signifi cant for ROP causation on logistic regression analysis in babies weighing ≤1800 g and MV (P < 0.01) and resuscitation (P < 0.01) were signifi cant for babies weighing 1501-1800 g. Conclusion: It should be considered to incorporate screening of babies ≤1800 g uniformly in developing nations. It is recommended that further studies be done taking representative population of babies in different sites with adequate follow-up.

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Section: Figure 1bsupporting

confidence: 69%

Retinopathy of prematurity in babies weighing <1800 g; with special reference to babies weighing between 1501 and 1800 g: An experience from a tertiary care hospital in Delhi

Kapoor

Talwar

Sachdeva

et al. 2014

Int J Med Public Health

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“…2,3 The strong associations reported between neonatal diagnoses or therapies and subsequent ROP suggest that severe illness, or an unstable fluctuating hospital course in general, are associated with risk for developing severe ROP. [4][5][6][7][8][9][10][11][12][13][14] Standardized illness severity (IS) measurements are widely used to account for variations in neonatal outcomes among hospitals. 15 The Score for Neonatal Acute Physiology (SNAP score) 16 on the first day of life appears associated with development of any ROP 17 and severe ROP.…”

Section: Introductionmentioning

confidence: 99%

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

et al. 2007

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Objective: To test cumulative neonatal illness severity (IS) and IS fluctuation as predictors of progression from moderate to severe retinopathy of prematurity (ROP).Study Design: Data from research databases and medical record review were collected for infants from four neonatal intensive care unit (NICUs) admitted between 1995 and 2001 and diagnosed with prethreshold ROP. Cumulative neonatal IS measured using daily Scores for Neonatal Acute Physiology (SNAP) for the first 28 days of life, and IS fluctuation as assessed by summing changes between daily SNAP scores, were tested as predictors of progression to threshold ROP using logistic regression.Result: Infants progressing to threshold (n ¼ 79), compared to those not progressing to threshold (n ¼ 130), had significantly (P<0.05) lower gestational ages (25.2±1.1 versus 25.8±1.4 weeks), higher cumulative neonatal SNAP (255±77 versus 224±63 weeks) and had more severe hospitalizations as indicated by diagnoses and medical management. In regression analysis, gestational age, chronological age and presence of plus disease at first diagnosis of prethreshold were associated with development of threshold. After adjusting for these factors, cumulative neonatal SNAP was significantly associated with progression to threshold. However, addition of cumulative SNAP to the model only increased receiver-operating characteristic curve area from 0.77 to 0.78 (NS). Other factors, including SNAP fluctuation, were not associated with progression to threshold after adjustment using this model. Conclusion:Cumulative neonatal IS, as measured by cumulative SNAP, is an independent risk factor for progression from moderate to severe ROP. However, cumulative IS does not enhance assessment of risk for ROP progression after adjusting for simpler clinical factors.

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“…Estes achados poderiam justificar parcialmente esta associação, pois em nosso estudo ocorreu um aumento da frequência do está-gio III da doença (mais grave), entretanto, não foi pesquisado o estágio pré-limiar definido no STOP-ROP especificamente. O uso de corticóides antenatal também não mostrou significância estatística (p=0,40), diferindo de outros trabalhos (24) . O fato de apresentar uma amostra com apenas 70 pacientes pode ter prejudicado esta associação.…”

Section: Discussionunclassified

Frequência de retinopatia da prematuridade em recém-nascidos no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo

Shinsato¹,

Paccola²,

Gonçalves³

et al. 2010

Arq. Bras. Oftalmol.

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Antenatal Dexamethasone and Decreased Severity of Retinopathy of Prematurity

Abstract: To assess risk factors associated with the development of retinopathy of prematurity (ROP) in an urban population.

Cited by 97 publications

References 17 publications

Retinopathy of prematurity in babies weighing <1800 g; with special reference to babies weighing between 1501 and 1800 g: An experience from a tertiary care hospital in Delhi

Retinopathy of prematurity in babies weighing <1800 g; with special reference to babies weighing between 1501 and 1800 g: An experience from a tertiary care hospital in Delhi

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

Frequência de retinopatia da prematuridade em recém-nascidos no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo

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