Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

Hagadorn, James I.; Richardson, Douglas K.; Schmid, Christopher H.; Cole, Cynthia H.

doi:10.1038/sj.jp.7211780

Cited by 25 publications

(19 citation statements)

References 43 publications

(33 reference statements)

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“…Use of prenatal corticosteroids did not show any statistical impact on development of ROP, which has not been shown in other studies. 24 The presence of sepsis in our study was considered to be a risk factor for ROP and showed significance. In the literature, this association has already been described.…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for retinopathy of prematurity in a Brazilian reference service

et al. 2014

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CONTEXT AND OBJECTIVE: Retinopathy of prematurity (ROP) is a known cause of blindness in which diagnosis and timely treatment can prevent serious harm to the child. This study aimed to evaluate the incidence of ROP and its association with known risk factors. DESIGN AND SETTING: Longitudinal incidence study in the neonatal intensive care unit (NICU) of Universidade Estadual de Montes Claros. METHODS: Newborns admitted to the NICU with gestational age less than 32 weeks and/or birth weight less than 1,500 grams, were followed up over a two-year period. The assessment and diagnosis of ROP were defined in accordance with a national protocol. The chi-square test or Fisher's exact test were used to determine associations between independent variables and ROP. Analysis on the independent effect of the variables on the results was performed using multiple logistic regression. RESULTS: The incidence of ROP was 44.5% (95% confidence interval, CI = 35.6-46.1) in the study population. The risk factors associated with the risk of developing the disease were: birth weight less than 1,000 grams (odds ratio, OR = 4.14; 95% CI = 1.34-12.77); gestational age less than 30 weeks (OR = 6.69; 95% CI = 2.10-21.31); use of blood derivatives (OR = 4.14; 95% CI = 2.99-8.99); and presence of sepsis (OR = 1.99; 95% CI = 1.45-2.40). CONCLUSIONS: The incidence of ROP was higher than that found in the literature. The main risk factors were related to extreme prematurity. RESUMO CONTEXTO E OBJETIVO:A retinopatia da prematuridade (ROP) é causa conhecida de cegueira e diagnóstico e tratamento oportunos podem evitar graves danos à criança. Este estudo objetivou avaliar a incidência da ROP e sua associação com fatores de risco conhecidos.

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Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for retinopathy of prematurity in a Brazilian reference service

et al. 2014

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“…However, after adjusting for other risk factors, cumulative SNAP was unable to accurately predict the desired outcome (threshold ROP). 26,27 SNAPPE-II has been used as a standard score in the NICU of our Institution since 2004. SNAPPE-II estimates illness severity using nine physiological and laboratory parameters collected within the first 12 h of life of preterm patients.…”

Section: Discussionmentioning

confidence: 99%

A predictive score for retinopathy of prematurity in very low birth weight preterm infants

Eckert

Filho

Maia

et al. 2011

Eye

104

102

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Aims This study describes the development of a score based on cumulative risk factors for the prediction of severe retinopathy of prematurity (ROP) comparing the performance of the score against the birth weight (BW) and gestational age (GA) in order to predict the onset of ROP. Methods A prospective cohort of preterm infants with BWp1500 g and/or GAp32 weeks was studied. The score was developed based on BW, GA, proportional weight gain from birth to the 6th week of life, use of oxygen in mechanical ventilation, and need for blood transfusions from birth to the 6th week of life. The score was established after linear regression, considering the impact of each variable on the occurrences of any stage and severe ROP. Receiver operating characteristic (ROC) curves were used to determine the best sensitivity and specificity values for the score. All variables were entered into an Excel spreadsheet (Microsoft) for practical use by ophthalmologists during screening sessions. Results The sample included 474 patients. The area under the ROC curve for the score was 0.77 and 0.88 to predict any stage and severe ROP, respectively. These values were significantly higher for the score than for BW (0.71) and GA (0.69) when measured separately. Conclusions ROPScore is an excellent index of neonatal risk factors for ROP, which is easy to record and more accurate than BW and GA to predict any stage ROP or severe ROP in preterm infants. The scoring system is simple enough to be routinely used by ophthalmologists during screening examination for detection of ROP.

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“…The research on the various risk factors is extensive in literature. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Finding an easily applicable and noninvasive prognostic model for the expected course of ROP is a keystone in controlling this socially signifi cant disease. This will allow us to focus the limited human and fi nancial resource in Bulgaria on patients at risk.…”

mentioning

confidence: 99%

The 5-minute Apgar Score as a Prognostic Factor for Development and Progression of Retinopathy of Prematurity

Marinov¹,

Koleva-Georgieva²,

Sivkova³

et al. 2017

Folia Medica

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Citation: Marinov VG, KolevaGeorgieva DN, Sivkova NP, Krasteva MB. The 5-minute Apgar score as a prognostic factor for development and progression of retinopathy of prematurity.Folia Medica 2017;59(1): 78-83. doi: 10.1515/folmed-2017-0011 Background: A low Apgar score at 5 minutes has been shown to be a risk factor for development of retinopathy of prematurity (ROP). Aim: To examine the prognostic value of Apgar score at 5 minutes for development and progression of ROP. Materials and methods:The study included 132 preterm infants who were screened from 4th week of life onward. Of these, 118 newborns were given Apgar score at 5 minutes. The prognostic signifi cance of this index was studied as an absolute value and as a value ≤ 6. The patients were divided into two groups: group I had no evidence of ROP (n=82) and group II had some signs of ROP (n = 36). Group II was further divided into group IIA -spontaneously regressed cases (n=22), and group IIB with cases which progressed to treatment stages (n=14). We investigated 15 maternal and 20 newborn presumable risk factors for development and progression of ROP. Mann-Whitney U test, χ 2 or Fisher's exact test were used in the statistical analysis. Logistic regression was performed to fi nd signifi cant and independent risk factors for manifestation and progression of ROP. Results: A low 5-minute Apgar score and an Apgar score of 6 or less at 5 minutes were not statistically signifi cant risk factors of ROP (р=0.191, р=0.191, respectively), but were signifi cant risk factors for the manifested ROP to progress to stages requiring treatment (p=0.046, р=0.036, respectively). Conclusion: An Apgar score at 5 minutes of 6 or less was a signifi cant and independent risk factor for progression of ROP to stages requiring treatment. BACKGROUND

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Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

Cited by 25 publications

References 43 publications

Incidence and risk factors for retinopathy of prematurity in a Brazilian reference service

Incidence and risk factors for retinopathy of prematurity in a Brazilian reference service

A predictive score for retinopathy of prematurity in very low birth weight preterm infants

The 5-minute Apgar Score as a Prognostic Factor for Development and Progression of Retinopathy of Prematurity

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