Antenatal depression: Prevalence and risk factor patterns across the gestational period

Couto, Tiago Castro e; Cardoso, Mauro Nogueira; Brancaglion, Mayra Yara Martins; Faria, Gustavo Coutinho; Garcia, Fernando Coutinho; Nicolato, Rodrigo; Miranda, Débora Marques de; Corrêa, Humberto

doi:10.1016/j.jad.2015.12.017

Cited by 42 publications

(46 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our reported prevalence rate of depressive symptoms ranging from 10 to 15% throughout gestation is comparable to recent literature, (Allbaugh et al 2015; Ashley et al 2016; Castro e Couto et al 2016; Lara et al 2015; Quispel et al 2014) as well as our mean EDS scores (Bergink et al 2011; Meijer et al 2014b; Rallis et al 2014). These studies, however, did not focus on the characteristics of women with persistent symptoms of depression.…”

Section: Discussionsupporting

confidence: 91%

Different patterns of depressive symptoms during pregnancy

Truijens

Spek

Son

et al. 2017

Arch Womens Ment Health

View full text Add to dashboard Cite

Recently, the US Preventive Services Task Force has advocated to screen pregnant and postpartum women for depression. However, we questioned the meaning of a single elevated depression score: does it represent just one episode of depression or do these symptoms persist throughout the entire pregnancy? This study assessed depressive symptoms at each trimester in a cohort of 1813 pregnant women and evaluated whether women with different patterns of depressive symptoms showed other characteristics. Depending on the trimester, elevated depression scores were prevalent in 10–15% of the pregnant women. Up to 4% reported persistent symptoms of depression throughout pregnancy. Different patterns of depressive symptoms were observed, for which persistent symptoms were related to other characteristics than incidentally elevated symptoms. Besides a previous history of mental health problems as best overall predictor, incidentally elevated depression scores were related to major life events. Furthermore, persistently depressive symptoms were related to unplanned pregnancy and multiparity. An EDS assessment at 12 weeks of gestation including three additional items (history of mental health problems, unplanned pregnancy and multiparity) enabled us to identify 83% of the women with persistent depressive symptoms. A depression screening strategy in pregnant women should take into account the potential chronicity of depressive symptoms by repeated assessments in order to offer an intervention to the most vulnerable women.

show abstract

Section: Discussionsupporting

confidence: 91%

Different patterns of depressive symptoms during pregnancy

Truijens

Spek

Son

et al. 2017

Arch Womens Ment Health

View full text Add to dashboard Cite

show abstract

“…(5,16) In Brazil, a longitudinal study with cut-off point ≥11 presented higher frequencies, with 33.3% in the second gestational trimester and 27.9% in the third. (17) These variations may result from different ways of using the EPDS for gestational age and cut-off points. Thus, the analysis of the results obtained in studies should consider these methodological aspects.…”

Section: Discussionmentioning

confidence: 99%

“…In longitudinal studies conducted in Brazil and Turkey and in a review study, one of the factors associated with gestational depression was exposure to domestic violence. (17,25,26) Currently, violence against women is a highly valued social problem that has received recognition from governmental agencies. According to the Low Risk Prenatal Care Handbook, a mistreated pregnant woman develops a condition of constant emotional stress associated with low self-esteem, isolation and suicide, excessive or abusive use of cigarettes, alcohol and drugs.…”

Section: Discussionmentioning

confidence: 99%

Sintomas depressivos na gestação e fatores associados: estudo longitudinal

et al. 2017

View full text Add to dashboard Cite

Objective: To identify the frequency of depressive symptoms during pregnancy and verify their association with sociodemographic, obstetric and health variables. Methods: A longitudinal study conducted with 272 pregnant women in 12 health units in the city of São Paulo. Data were obtained using a form for the independent variables, and the Edinburgh Postpartum Depression Scale applied at the 20 th , 28 th and 36 th gestational weeks. A model of generalized estimating equations was used to evaluate the associated factors and odds ratio. Results: The frequency of depressive symptoms was 27.2%, 21.7% and 25.4%. Higher educational level, planned pregnancy and continuity of gestation were protective factors. Suffering or having suffered psychological violence was an independent risk factor of the gestational period. Conclusion: The frequency of depressive symptoms during pregnancy was high. The associated factors were higher educational level, planned pregnancy, continuity of pregnancy, and suffering or having suffered psychological violence. ResumoObjetivo: Identificar a frequência de sintomas depressivos no decorrer da gestação e verificar sua associação com variáveis sociodemográficas, obstétricas e de saúde. Métodos: Estudo longitudinal realizado com 272 gestantes de 12 unidades de saúde do Município de São Paulo. Os dados foram obtidos por meio de um formulário para as variáveis independentes e da Escala de depressão pós-parto de Edimburgo aplicada nas 20ª, 28ª e 36ª semanas gestacionais. Utilizou-se modelo de equações de estimação generalizadas para avaliar os fatores associados e chances de risco. Resultados: A frequência de sintomas depressivos foi de 27,2%, 21,7% e 25,4%. Maior escolaridade, gestação planejada e continuidade da gestação foram fatores de proteção. Sofrer ou ter sofrido violência psicológica foi fator de risco independente do período gestacional. Conclusão: A frequência de sintomas depressivos na gestação foi elevada. Os fatores associados foram maior escolaridade, gestação planejada, continuidade da gestação e sofrer ou ter sofrido violência psicológica.

show abstract

“…Stress-related symptoms of anxiety and depression are common in pregnant women (Burns et al, 2015), and epidemiologic studies suggest that not only is prenatal stress associated with preterm birth and low birth weight, it may also alter brain development (Baron et al, 2015, Burns et al, 2015, Castro et al, 2015, Robbins et al, 2014). In a broad range of preclinical and clinical studies, prenatal exposure to stress-related conditions has been shown to potently stimulate biological stress pathways,(Constantinof et al, 2015) alter synaptogenesis (Bale et al, 2010, Singh-Taylor et al, 2015) and result in changes in structural brain development (Qiu et al, 2015, Qiu et al, 2013, Rifkin-Graboi et al, 2013, Rifkin-Graboi et al, 2015, Van Dam et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Prenatal stress alters amygdala functional connectivity in preterm neonates

Mayes

Kwon

Lacadie

et al. 2016

NeuroImage: Clinical

103

View full text Add to dashboard Cite

Exposure to prenatal and early-life stress results in alterations in neural connectivity and an increased risk for neuropsychiatric disorders. In particular, alterations in amygdala connectivity have emerged as a common effect across several recent studies. However, the impact of prenatal stress exposure on the functional organization of the amygdala has yet to be explored in the prematurely-born, a population at high risk for neuropsychiatric disorders.We test the hypothesis that preterm birth and prenatal exposure to maternal stress alter functional connectivity of the amygdala using two independent cohorts. The first cohort is used to establish the effects of preterm birth and consists of 12 very preterm neonates and 25 term controls, all without prenatal stress exposure. The second is analyzed to establish the effects of prenatal stress exposure and consists of 16 extremely preterm neonates with prenatal stress exposure and 10 extremely preterm neonates with no known prenatal stress exposure. Standard resting-state functional magnetic resonance imaging and seed connectivity methods are used.When compared to term controls, very preterm neonates show significantly reduced connectivity between the amygdala and the thalamus, the hypothalamus, the brainstem, and the insula (p < 0.05). Similarly, when compared to extremely preterm neonates without exposure to prenatal stress, extremely preterm neonates with exposure to prenatal stress show significantly less connectivity between the left amygdala and the thalamus, the hypothalamus, and the peristriate cortex (p < 0.05). Exploratory analysis of the combined cohorts suggests additive effects of prenatal stress on alterations in amygdala connectivity associated with preterm birth.Functional connectivity from the amygdala to other subcortical regions is decreased in preterm neonates compared to term controls. In addition, these data, for the first time, suggest that prenatal stress exposure amplifies these decreases.

show abstract

Antenatal depression: Prevalence and risk factor patterns across the gestational period

Cited by 42 publications

References 59 publications

Different patterns of depressive symptoms during pregnancy

Different patterns of depressive symptoms during pregnancy

Sintomas depressivos na gestação e fatores associados: estudo longitudinal

Prenatal stress alters amygdala functional connectivity in preterm neonates

Contact Info

Product

Resources

About