Angiotensin II type 1 and 2 receptors gene polymorphisms in pre‐eclampsia and normal pregnancy in three different populations

Akbar, Syed Ali; Khawaja, Nuzhat Parveen; Brown, Paul; Tayyeb, Rakhshanda; Bamfo, Jacqueline; Nicolaides, Kypros H.

doi:10.1080/00016340902859307

Cited by 35 publications

(37 citation statements)

References 30 publications

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“…Studies showed that the distribution of gene polymorphisms differed among different ethnic populations. The result of a meta-analysis is likely to be affected by the population sources of study subjects, and thus the conclusions drawn from studies based on other populations may not be appropriate for a specific population [38]. It is necessary to conduct a meta-analysis to evaluate the associations between ACE I/D, AGT M235T, and PIH among Chinese populations.…”

Section: Discussionmentioning

confidence: 99%

Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis

Zhu

Zhang

Nie

et al. 2012

J Assist Reprod Genet

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Purpose There have been many studies concerning the associations of angiotensin-converting enzyme (ACE) I/D, angiotensinogen (AGT) M235T polymorphisms with pregnancy induced hypertension (PIH) among Chinese populations. However, the results were inconsistent, prompting the necessity of meta-analysis. Methods Studies published in English and Chinese were mainly searched in EMbase, PubMed and CBM up to January 2012. Results Twenty-three studies with 3,551 subjects for ACE I/D and seven studies with 1,296 subjects for AGT M235T were included. Significant associations were found between ACE I/D and PIH under dominant, recessive and allelic models. A separate analysis confined to preeclampsia suggested that ACE I/D was associated with preeclampsia under recessive model and allelic model, but not dominant model. Stratified analyses were conducted as meta-regression analysis indicated that the sample size of case group was a significant source of heterogeneity, which suggested no significant association between ACE I/D and PIH in the subgroup of more than 100 cases. Associations were found between AGT M235T and PIH under dominant genetic model (OR01.59; 95 %CI: 1.04-2.42), recessive genetic model (OR01.60; 95 %CI: 1.07-2.40), and allelic model (OR 01.40; 95 %CI: 1.17-1.68). No publication bias was found in either meta-analysis. Conclusions The present meta-analysis suggested significant associations between ACE I/D, AGT M235T and PIH in Chinese populations. However, no significant association was found between ACE I/D and PIH in the subgroup of more than 100 cases. Studies with larger sample sizes are necessary to investigate the associations between gene polymorphisms and PIH in Chinese populations.

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Section: Discussionmentioning

confidence: 99%

Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis

Zhu

Zhang

Nie

et al. 2012

J Assist Reprod Genet

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“…24 The studies of Seremak-Mrozikiewicz et al in 2005 confirmed the association of the A1166C (AT2R1) polymorphism and pre-eclampsia, but other studies performed by GOPEC (The Genetics of Pre-eclampsia Consortium) researchers, and Akbar et al revealed inconsistent results. [25][26][27] Regarding the polymorphisms located in the renin gene, there are no positive results on the association with the risk of pre-eclampsia. 28 As placental and foetal membranes are important production sites of the RAS components, we also evaluated the possible influence of the mutated newborn RAS genes on the risk of pre-eclampsia.…”

Section: Discussionmentioning

confidence: 99%

Maternal/newborn genotype contribution of the renin–angiotensin system (Met235Thr, Thr174Met, I/D-ACE, A2350G-ACE, A1166C-AT2R1, C3123A- AT2R2, ⁸³A/G-REN) to the risk of pre-eclampsia: a Romanian study

Procopciuc

Caracostea

Zaharie

et al. 2011

J Renin Angiotensin Aldosterone Syst

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Introduction:We evaluated the association of the mutated genotypes Met235Thr-AGT, Thr174Met-AGT, I/D-ACE, A2350G-ACE, A1166C-AT2R1, C3123A-AT2R2, 83 A/G-REN with the risk and outcome of pre-eclampsia; we also investigated whether genes in newborns increase maternal risk of pre-eclampsia. Materials and methods: Thirty-six pairs of pre-eclamptic women and their newborns were genotyped, along with 71 pairs of controls (mothers/newborns) using PCR-RFLP analysis. Results: The Thr235/Thr235 (OR 3.44, p = 0.01), DD (OR 2.66, p = 0.039), CC1166 (OR 5.56, p = 0.04), AA3123 (OR 3.77, p = 0.03) and GG 83 (OR 8.32, p = 0.006) genotypes are significantly associated with pre-eclampsia. Women with pre-eclampsia positive for Met235Thr (34.64 ± 3.92 weeks vs. 38 ± 2 weeks), Thr174Met (32.58 ± 3.92 weeks vs. 36.38 ± 3.25 weeks), I/D (34.47 ± 3.67 weeks vs. 38.33 ± 3.5 weeks) delivered at a significant lower gestational age compared with pre-eclamptic women with a normal genotype. Newborns from women with pre-eclampsia positive for Thr174Met (2190 ± 820.21 g vs. 2702.08 ± 967.23 g), I/D (2399.33 ± 938.38 g vs. 3191.66 ± 684.40 g) had a significant lower birth weight compared with newborns from women with normal pregnancies. When both the mother and the newborn were positive for Met235Thr,

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“…6,7 There are controversial reports from different populations related to the role of ACE I/D polymorphism in the pathogenesis of preeclampsia. 1,3,[8][9][10][11][12][13][14][15][16][17] Also, in a few studies the association of AT1R A1166C polymorphism with preeclampsia has been examined. [8][9][10]17 A positive relationship between the degree of oxidative stress and the clinical severity of preeclampsia has been reported, suggesting that the toxic effects of lipoperoxide lead to hypertension, endothelial damage and leukocyte activation.…”

Section: Introductionmentioning

confidence: 99%

Preeclampsia and angiotensin converting enzyme (ACE) I/D and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms: association with ACE I/D polymorphism

Rahimi

Mozafari

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Background: The aim of the present study was to investigate the association between angiotensin converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms with the risk of preeclampsia and lipid peroxidation in preeclamptic women from Western Iran. Methods: One hundred and ninety-eight preeclamptic women (128 women with mild and 70 with severe forms) and 100 age-and parity-matched controls were enrolled in this case-control study. Results:The presence of D allele of ACE was associated with a 1.8-fold increased risk of preeclampsia (p=0.002) in total preeclamptic patients. The frequency of AT1R AC+CC genotypes was higher in mild preeclamptic women (32%) compared to controls (27.2%) (p>0.05). In mild preeclamptic women with ID genotype, the level of total antioxidant capacity (TAC) was significantly decreased compared to those with II genotype. Also, there was a trend toward increasing malondialdehyde (MDA) and decreasing TAC levels in mild and severe preeclamptic women with AT1R AA through CC genotypes. Conclusions: Our study indicates that lipid peroxidation and oxidative stress are involved in the development of preeclampsia that might be influenced by polymorphism in the renin-angiotensin-aldosterone system genes.

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Angiotensin II type 1 and 2 receptors gene polymorphisms in pre‐eclampsia and normal pregnancy in three different populations

Abstract: There is an association between PE/E and the GG-genotype of AT2R in Afro-Caribbean women.

Cited by 35 publications

References 30 publications

Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis

Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis

Maternal/newborn genotype contribution of the renin–angiotensin system (Met235Thr, Thr174Met, I/D-ACE, A2350G-ACE, A1166C-AT2R1, C3123A- AT2R2, ⁸³A/G-REN) to the risk of pre-eclampsia: a Romanian study

Preeclampsia and angiotensin converting enzyme (ACE) I/D and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms: association with ACE I/D polymorphism

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Angiotensin II type 1 and 2 receptors gene polymorphisms in pre‐eclampsia and normal pregnancy in three different populations

Abstract: There is an association between PE/E and the GG-genotype of AT2R in Afro-Caribbean women.

Cited by 35 publications

References 30 publications

Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis

Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis

Maternal/newborn genotype contribution of the renin–angiotensin system (Met235Thr, Thr174Met, I/D-ACE, A2350G-ACE, A1166C-AT2R1, C3123A- AT2R2, 83A/G-REN) to the risk of pre-eclampsia: a Romanian study

Preeclampsia and angiotensin converting enzyme (ACE) I/D and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms: association with ACE I/D polymorphism

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Maternal/newborn genotype contribution of the renin–angiotensin system (Met235Thr, Thr174Met, I/D-ACE, A2350G-ACE, A1166C-AT2R1, C3123A- AT2R2, ⁸³A/G-REN) to the risk of pre-eclampsia: a Romanian study