Preeclampsia and angiotensin converting enzyme (ACE) I/D and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms: association with ACE I/D polymorphism

Rahimi, Zohreh; Rahimi, Ziba; Mozafari, Hadi; Parsian, Abbas

doi:10.1177/1470320312448950

Cited by 39 publications

(27 citation statements)

References 33 publications

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“…[13,15,17] In addition, the populations of Romania and the United States revealed the associations of DD ACE genotype with the development of preeclampsia. [12,14] Besides, the studies conducted in the populations of India, China, and Colombia, revealed no significant effect of I/D ACE on the development of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

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Reshetnikov

2017

AJP

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Objectives: The associations of the insertion-deletion angiotensin-converting enzyme (I/D ACE) genetic polymorphism with the risk of preeclampsia development were studied. Materials and Methods: The study group included 350 women: 100 women with a physiological pregnancy and 250 pregnant women with preeclampsia. All women underwent the typing of I/D polymorphism of the ACE gene. Results: The pregnant women with the preeclampsia of the 2 nd degree of severity showed the lowest concentration of genotype II ACE (11.00%) as compared with pregnant women without preeclampsia (25.00%; odds ratio [OR] = 0.37; P = 0.017; P cor = 0.051). With the preeclampsia of the 3 rd degree of severity, the minimum frequency of the genotype II ACE (7.27%) and the maximum frequency of the allele D ACE (62.73%) are recorded among pregnant women as compared with the pregnant women without preeclampsia (25.00%; OR = 0.24; P = 0.01; P cor = 0.03 and 49.50%, OR = 1.72, P = 0.03, respectively). Conclusions: Thus, the D ACE allele is associated with the risk of preeclampsia development of the 3 rd degree of severity, and the ACE genotype II is a protective factor of preeclampsia development of the 2 nd and the 3 rd degree of severity.

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Section: Discussionmentioning

confidence: 99%

“…[8][9][10] The available data on the relationship between the polymorphism of ACE gene and the risk of preeclampsia development are contradictory. [11][12][13][14][15][16][17][18][19][20] In this regard, further research is needed to study the role of I/D ACE locus in the development of this complication of pregnancy.…”

Section: Original Articlementioning

confidence: 99%

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Reshetnikov

2017

AJP

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“…It is the presence of pathological alleles in the AGTR1 gene associated with development of vascular disorders including those not related to blood pressure levels [55,56]. There are also data about the absence of rare allele C of SNP 1166 A4C in AGTR1 gene influence on the violation of pregnancy [57].…”

Section: Snps In the Renin-angiotensin Systemmentioning

confidence: 99%

“…This multifunctional protein plays a key role in processes such as regulation of blood pressure, maintain a balance of electrolytes, platelet activation and aggregation, fibrinolysis. ACE protein functionality and features of its expression, associated with the presence of Alu-sequences in the intron, are devoted to a great number of publications [55,56,[60][61][62]. Virtually all studies agree that the presence of variant D (Del), lack of Alu-sequences in the intron of the ACE gene, is associated with atherosclerotic, cardiovascular disorders and the risk of pregnancy violation [29,61,62].…”

Section: Snps In the Renin-angiotensin Systemmentioning

confidence: 99%

Toward optimal set of single nucleotide polymorphism investigation before IVF

Ivanov

Dedul

Fedotov

et al. 2016

Gynecological Endocrinology

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Background: At present, the patient preparation for IVF needs to undergo a series of planned tests, including the genotyping of single nucleotide polymorphism (SNP) alleles of some genes. In former USSR countries, such investigation was not included in overwhelming majority of health insurance programs and paid by patient. In common, there are prerequisites to the study of more than 50 polymorphisms. An important faced task is to determine the optimal panel for SNP genotyping in terms of price/number of SNP. Materials and methods: During 2009-2015 in the University Hospital of St. Petersburg State University, blood samples were analyzed from 550 women with different reproductive system disorders preparing for IVF and 46 healthy women in control group. In total, 28 SNP were analyzed in the genes of thrombophilia factors, folic acid cycle, detoxification system, and the renin-angiotensin system. The method used was real-time PCR. Results: A significant increase in the frequency of pathological alleles of some polymorphisms in patients with habitual failure of IVF was shown, compared with the control group. As a result, two options defined panels for optimal typing SNP before IVF were composed. Standard panel includes 8 SNP, 5 in thromborhilic factors, and 3 in folic acid cycle genes. They are 20210 G4A of FII gene, R506Q G4A of FV gene (mutation Leiden), -675 5G44G of PAI-I gene, L33P T4C of ITGB3 gene, -455 G4A of FGB gene, 667 C4T of MTHFR gene, 2756 A4G of MTR gene, and 66 A4G of MTRR gene. Extended panel of 15 SNP also includes 807 C4T of ITGA2 gene, T154M C4T of GP1BA gene, second polymorphism 1298 A4C in MTHFR gene, polymorphisms of the renin-angiotensin gene AGT M235T T4C and -1166 A4C of AGTR1 gene, polymorphisms I105V A4G and A114V C4T of detoxification system gene GSTP. Conclusion:The results of SNP genotyping can be adjusted for treatment tactics and IVF, and also medical support getting pregnant. The success rate of IVF is increased as the result, especially in the group with the usual failure of IVF.

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“…We are unaware of such studies correlating ACE gene I/D polymorphism with response to antihypertensive in PE as well as GH patients. The choice of ACE gene was based on the reports claiming an association of D allele with a predisposition to PE and the protective role of "II" homozygote [8][9][10]. In a similar study, a single nucleotide polymorphism in endothelial nitric oxide synthase coding gene affecting the nitric oxide (NO) production was correlated with antihypertensive treatment in PE and GH [11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Response to Antihypertensive’s in Preeclampsia and Gestational Hypertension Cases With Different Ace Gene Insertion/Deletion Genotypes

Ishaq

Afreen

Ali

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this research study was to investigate if there exists a relationship between angiotensin converting enzyme (ACE) genes insertion/deletion (I/D) genotypes and the antihypertensive treatment being received by preeclampsia (PE) and gestational hypertension (GH) patients. Methods:A total of 50 PE and 35 GH cases were included. ACE gene I/D genotyping was carried out on the blood samples of cases and correlated with the antihypertensive treatment being received by these patients. Details of antihypertensives being received by them were nifedipine (a calcium channel blocker 10 mg) and methyldopa (an alpha 2 receptor agonist 250 mg) which is considered as the first-line of treatment. 30 normotensive pregnant women of comparable gestational period served as controls. Results:It was observed that a combination of calcium channel blocker (nifedipine 10 mg), as well as alpha 2 agonist (methyldopa 250 mg), was required in patients with D' allele containing genotypes. However, PE and GH patients with II genotype as well as those of GH patients responded well to either nifedipine or methyldopa. If confirmed these results appear to be of clinical significance as prior knowledge of ACE I/D genotypes will be useful in the management of PE cases in general and severe PE cases in particular. Conclusion:Prior knowledge of ACE I/D genotypes appears to be helpful in the management of PE and GH cases.

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Preeclampsia and angiotensin converting enzyme (ACE) I/D and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms: association with ACE I/D polymorphism

Cited by 39 publications

References 33 publications

Untitled

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Toward optimal set of single nucleotide polymorphism investigation before IVF

Evaluation of Response to Antihypertensive’s in Preeclampsia and Gestational Hypertension Cases With Different Ace Gene Insertion/Deletion Genotypes

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