There is an association between PE/E and the GG-genotype of AT2R in Afro-Caribbean women.

NLRP7 mutations do not represent a major cause of AnCHM.

No abstract

Background: Cervical cancer can be prevented, by regular screening by a test, called Pap smearand the most important risk factor for cervical cancer is “never having been screened”. Screening for cancer of the cervix remains a neglected health care issue in Pakistan. Objective: To assess the practices/ trends and attitude about personal Pap smear among female doctors working in field of obstetrics and gynecology. Study Design: Cross sectional descriptive study Place of study: Obstetrics and Gynaecology Department, Lahore General Hospital Lahore. Methodology: Five hundred lady doctors working in field of obstetrics and gynaecology were interviewed using a questionnaire. Data collected was analyzed by SPSS version 10. Results: Only 3.60% of lady doctors ever had Pap smear and 1.40% had regular Pap smear.Mean age of respondents was 36 year. Only 08%were of parity more than five, mean age of marriage was 26 years and 1.4% were married twice. Oralcontraceptive pills user were 14.6%.The most common reasons of not having Pap smear were embarrassment (16%), busy schedule and considering that they do not have risk of cervical cancer (14 %)and lack of counseling / reminder (11.20%). Conclusion: Female health professionals working in the field of obstetrics and gynaecology have negligible uptake of cervical cancer screening for their own selves despite being exposed to some of theimportant risk factors for carcinomacervix, which reflects their perception regarding importance of cervical cancer screening for women’s wellbeing. The results of this study may serve as a baseline for future comparisons. A larger community-based study may establish the exact trend, and will guide further planning in this regard.

Objective: To find out risk factors for hepatitis C infection in obstetric patients in a teaching hospital. Study Design -Observational study. Place and Duration At Sir Ganga Ram Hospital, Lahore during a period of one year. Subjects and Methods -Casesof hepatitis C infection, diagnosed on the basis of screening for antibodies for Hepatitis C were included in the study. A proforma was designedand details of each case including maternal demographics and associated risk factors were entered. Result Fifty three obstetric patients werepositive for Hepatitis C virus antibodies in one year of study period. Majority of women were among 25-29 years of age, belong to lowsocioeconomic status, illiterate and among parity range of 2-5. Previous history of surgical procedures was in 66% of subjects while 62% hadhistory of injections. Ear piercing in unsterilized conditions by non skilled person was also present in significant number (43%) while 17% hadhistory of blood transfusions. Conclusion: Hepatitis C infection is linked to surgical procedures, injections and ear piercing in this study.However, to identify all associated maternal risk factors, larger studies at multiple centres will be required and strategies should be made toprevent its' transmission.

Objectives: To audit the obstetric hysterectomies in a tertiary care hospital during one year. Methods: It was an observational retrospective study design, where all the pregnant women were assessed for fetomaternal outcomes, indications and complications for peripartum hysterectomy. The records were retrieved from Jan 2015 to Dec 2015 by using hospital record system. The study duration was of one year. The venue of the study was Lahore General hospital, Lahore. The exclusion criteria included all unmarried women, women with chronic kidney disease or renal failure, past surgical history of heart disease, whereas all the women who delivered in hospital, private clinic or at home after atleast 28 weeks of gestational age and experience hysterectomy at the time of delivery or after delivery in the puerperium, were included in the study. Results: The data over 32 women were retrieved from the hospital record system. The mean age of the women was 30.34+2.23 with range 26-34. The average number of parity was 3 of all females. The range of parity was 2 to 7. The average gestational age was 36.18 weeks. All the deliveries were done by cesarean section whereas 4 (12.5%) were elective and 28 (87.5%) were with emergency indications. 13 (40.6%) of the deliveries were in private clinic, 9 (28.1%) were done by LHV/ mid wife, 5(15.6%) were in private hospitals, 4(12.5%) were in LGH and only 1(3.1%) was at home. 18(56.3%) of the women were having at least one abortion in previous history. Conclusion: We concluded that emergency peripartum hysterectomy is very vital procedure that saves lives and manage life threatening obstetrical hemorrhage when other methods failed to control it.The major indications for emergency peripartum hysterectomy were placental abruption, placenta praevia/accrete, uterine atony and ruptured uterus. Key Words: Uterine artery embolization, Emergency peripartum hysterectomy, maternal morbidity and mortality, healthcare providers How to Cite: Latif F, Ilyas S, Mehmood S. Arif H. Khawaja P. Nuzhat. Jawad Z. J Clinical audit of obstetrical hysterectomies for a period of one year in a tertiary care hospital. Esculapio.2020;16(04):50-53.

Aim: To compare the frequency of recurrence of convulsions with Magnesium Sulphate loading dose versus loading dose plus maintenance regimen for management of patients presenting with eclampsia. Methods: In this Randomized Controlled Trial, 240 pregnant female admitted in department of Obstetrics & Gynaecology, LGH, Lahore. Half In group A, females were given MgSO4 in a single bolus dose i.e. 4 grams intravenously diluted in 100ml normal saline over 20 minutes and 10grams intramuscularly, while in group B, females were given complete standard regime according to the Pritchard i.e. 14 grams loading dose followed by 5gm intramuscularly every 4 hours on alternate buttock for 24 hours after the last episode of convulsion or delivery of the fetus whichever comes later. Results: In this study recurrence of convulsion was significantly higher in patients who were given MgSO4 loading dose as compared to patients who were given MgSO4 loading + maintenance regimen i.e. Group-A: 15.8% vs. Group-B: 5.8%, (p-value 0.013). The frequency of recurrence of convulsion was significantly higher in women who were given loading dose alone as that of women who were given MgSO4 loading + maintenance regimen but Age, gestational age and parity status of women although did not show any significant association.. Conclusion: Loading dose plus maintenance regimen had low frequency of recurrence convulsion when compared with loading dose of MgSO4 only. Keywords: Eclampsia, loading dose, Recurrence of convulsions, Magnesium Sulphate, Maintenance regimen