Angiogenic activity of sesamin through the activation of multiple signal pathways

Chung, Byung Hee; Lee, Jun Young; Kim, Jong Dai; Jeoung, Dooil; Lee, Hansoo; Choe, Jongseon; Ha, Kwon Soo; Kwon, Young Geun; Kim, Young Myeong

doi:10.1016/j.bbrc.2009.11.045

Cited by 45 publications

(32 citation statements)

References 22 publications

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“…Although some angiogenic compounds elicit the common angiogenic signal pathways of MEK/ERK, Src/FAK, and Akt/ eNOS, their apical targets or receptors have not been identified as yet (25,29). We found here that Rg5 specifically activated IGF-1R, which is associated with regulation of the EC function.…”

Section: Discussionmentioning

confidence: 59%

“…Some angiogenic inducers, including VEGF, evoke angiogenesis mainly by activating multiple signal pathways, such as MEK/ERK, Akt/eNOS, and Src/FAK, through binding their receptors (20,25). However, other factors indirectly activate angiogenic signaling by inducing angiogenic factor expression A-E, HUVECs were treated with Rg5 (20 M) in the presence or absence of RU486 (RU) (10 M), pertussis toxin (PT) (100 ng/ml), U73122 (U7) (5 M), or BAPTA-AM (BA) (10 M).…”

Section: Discussionmentioning

confidence: 99%

“…3C). We next examined the effects of Rg5 on the expression of adhesion molecules (ICAM-1 and VCAM-1) and VE-cadherin phosphorylation-mediated disruption of adherens junction, which are known adverse effects induced during angiogenic therapy using VEGF (25). Rg5 did not affect ICAM-1 and VCAM-1 expression in ECs and adhesion of monocytes to ECs, whereas VEGF promoted these vascular inflammatory events (Fig, 3, D and E).…”

Section: Rg5 Increases Angiogenesis In Vitro Ex Vivo and In Vivo-mentioning

confidence: 99%

“…Rg5 Does Not Induce Vascular Inflammation and PermeabilityThe angiogenic activity of some ginsenosides may be the result of either direct action on ECs or induction of pro-angiogenic genes, including VEGF (15,25). We determined whether Rg5 regulates VEGF expression in ECs.…”

Section: Rg5 Increases Angiogenesis In Vitro Ex Vivo and In Vivo-mentioning

confidence: 99%

“…Activation of ERK, Akt, and Src was observed at 10 min; however, eNOS, FAK, and paxillin phosphorylation occurred 20 min after Rg5 stimulation. Because phosphorylated eNOS increases NO production, which is involved in angiogenesis (2,3,25), we examined the effect of Rg5 on eNOSdependent NO production. Treatment with Rg5 promoted an increase in NO production, the effect of which was abrogated by co-treatment with the NOS inhibitor L-NAME (Fig.…”

Section: Rg5 Increases Angiogenesis In Vitro Ex Vivo and In Vivo-mentioning

confidence: 99%

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Specific Activation of Insulin-like Growth Factor-1 Receptor by Ginsenoside Rg5 Promotes Angiogenesis and Vasorelaxation

Cho

Hur

Kim

et al. 2015

Journal of Biological Chemistry

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Background:The mechanism by which ginsenoside Rg5 regulates vascular function remains unclear. Results: Rg5 increases angiogenesis and vasorelxation by activating multiple signal transduction pathways downstream of insulin-like growth fastor-1 receptor (IGF-1R). Conclusion: Rg5 promotes endothelial cell function through activation of IGF-1R. Significance: These findings reveal a mechanism for the positive regulation of vascular function by Rg5-mediated IGF-1R activation.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Rg5 Increases Angiogenesis In Vitro Ex Vivo and In Vivo-mentioning

confidence: 99%

Section: Rg5 Increases Angiogenesis In Vitro Ex Vivo and In Vivo-mentioning

confidence: 99%

Section: Rg5 Increases Angiogenesis In Vitro Ex Vivo and In Vivo-mentioning

confidence: 99%

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Specific Activation of Insulin-like Growth Factor-1 Receptor by Ginsenoside Rg5 Promotes Angiogenesis and Vasorelaxation

Cho

Hur

Kim

et al. 2015

Journal of Biological Chemistry

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Biological Properties of Lignans

Calvo‐Flores

Dobado

Isac‐García

et al. 2015

Lignin and Lignans as Renewable Raw Materials

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Stereoselective Synthesis of Lignans of Three Structural Types from a Common Intermediate, Enantioselective Synthesis of (+)‐Yangambin

2014

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Enantioselective total synthesis of (+)‐yangambin was achieved. The key transformation is one‐pot conjugate addition/aldol reaction that involves an enantioenriched benzyl tert‐butyl sulfoxide, an enone, and gaseous formaldehyde to construct the bis(phenylpropanoid) backbone with excellent stereoselectivity and in good yield. Reduction of the ketone with diisobutylaluminium hydride and acid‐catalysed cyclisation in EtOH furnished (+)‐yangambin in good yield. The resulting synthesis is short, efficient and highly selective. Formation of 2,5‐diaryltetrahydrofuran lignans was observed as a side reaction in the final step of yangambin synthesis. Acid‐catalysed cyclisation of the aldol intermediate gave a completely different outcome. Dehydration to give an enone was followed by two electrophilic aromatic substitution reactions to furnish a derivative of the lignan lirionol.

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Angiogenic activity of sesamin through the activation of multiple signal pathways

Cited by 45 publications

References 22 publications

Specific Activation of Insulin-like Growth Factor-1 Receptor by Ginsenoside Rg5 Promotes Angiogenesis and Vasorelaxation

Specific Activation of Insulin-like Growth Factor-1 Receptor by Ginsenoside Rg5 Promotes Angiogenesis and Vasorelaxation

Biological Properties of Lignans

Stereoselective Synthesis of Lignans of Three Structural Types from a Common Intermediate, Enantioselective Synthesis of (+)‐Yangambin

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