Analysis of various risk factors affecting potentially malignant disorders and oral cancer patients of Central India

Kadashetti, Vidya; Chaudhary, Minal; Patil, Swati; Gawande, Madhuri; Shivakumar, K. M.; Patil, Snehal; Pramod, R

doi:10.4103/0973-1482.151417

Cited by 35 publications

(36 citation statements)

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Section: Discussionsupporting

confidence: 92%

“…In view of the evident differences in the distribution of age, ethnicity and SES between cases and controls, these parameters were controlled for as confounders in the analysis for differences in the practice of risk habits between these two groups. As expected, the carcinogenic effect of smoking and BQ chewing on its own is further validated, concurring with earlier reports (Jayalekshmi et al, ; Kadashetti et al, ; Subapriya et al, ; Thomas et al, ). In this study, alcohol consumption alone was found to confer a non‐significant increased risk for oral cancer, which is in concordance with findings from studies conducted in India (Muwonge et al, ) and Taiwan (Lin et al, ).…”

Section: Discussionsupporting

confidence: 91%

“…The synergistic effect of combined risk habits has been demonstrated by numerous studies (Kadashetti et al, ; Lin et al, ; Madani et al, ) and has been shown to account for more than two‐thirds of oral cancers in South‐East Asia (Petti, Masood, & Scully, ). Similarly, this current study found that the odds for developing oral cancer were higher among those practicing multiple habits as compared to those practicing single habit.…”

Section: Discussionmentioning

confidence: 97%

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Multi‐ethnic variations in the practice of oral cancer risk habits in a developing country

et al. 2018

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Objective To elucidate ethnic variations in the practice of oral cancer risk habits in a selected Malaysian population. Methods This retrospective case–control study involves 790 cases of cancers of the oral cavity and 450 controls presenting with non‐malignant oral diseases, recruited from seven hospital‐based centres nationwide. Data on risk habits (smoking, drinking, chewing) were obtained using a structured questionnaire via face‐to‐face interviews. Multiple logistic regression was used to determine association between risk habits and oral cancer risk; chi‐square test was used to assess association between risk habits and ethnicity. Population attributable risks were calculated for all habits. Results Except for alcohol consumption, increased risk was observed for all habits; the highest risk was for smoking + chewing + drinking (aOR 22.37 95% CI 5.06, 98.95). Significant ethnic differences were observed in the practice of habits. The most common habit among Malays was smoking (24.2%); smoking + drinking were most common among Chinese (16.8%), whereas chewing was the most prevalent among Indians (45.2%) and Indigenous people (24.8%). Cessation of chewing, smoking and drinking is estimated to reduce cancer incidence by 22.6%, 8.5% and 6.9%, respectively. Conclusion Ethnic variations in the practice of oral cancer risk habits are evident. Betel quid chewing is the biggest attributable factor for this population.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

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Multi‐ethnic variations in the practice of oral cancer risk habits in a developing country

et al. 2018

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“…The synergistic effect on the carcinogenic potency of tobacco/betel quid in oral cancer by alcohol consumption is welldocumented in the literature. There are about 250 million tobacco/betel quid users in India who account for about 19% of the betel quid users /betel quid users [13].…”

Section: Discussionmentioning

confidence: 99%

A study on genetic polymorphism in Matrix Metalloproteinases-3 in oral submucous fibrosis patients and in healthy individuals

et al. 2017

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Background: OSF is a potentially malignant condition affecting the oral cavity and oropharynx. MMP-3 also known as Stromelysin -I is a key member of the MMP family which is responsible for degradation of collagen type II,IV,V,IX and X, proteoglycans, gelatins, fibronectin, laminin and elastin. It plays an important role in activation of pro MMP-1 into the active form of MMP-1 in malignant tissues. MMP-3 expression is low in normal tissues but it is altered during tumour formation, where remodeling of ECM is required. Purpose of the study: To assess the association of single-nucleotide polymorphisms, Adenosine (Insertion/ Deletion) in -1171 5A > 6A in the MMP-3 promoter regions of patients with oral submucous fibrosis and in healthy individuals (controls). Methods: Thirty cases of OSF were categorized according to Khanna et al classification into four groups and Twenty age and sex matched controls were included in the study. Blood samples were collected in EDTA coated vacutainers and PCR restriction analysis was done. A statistical analysis was done using Chi-square test and Fisher's exact test to assess the frequency and association of the alleles in the case-control group. Results: The result showed a statistical significance difference between the duration of habit and disease severity with polymorphisms. The result also showed a higher frequency of the 5A allele in the study group as compared to the controls. Conclusion: A long-term follow up of these patients is mandatory to see the prognosis and their susceptibility to malignancy. The positive outcome of an association of the disease with polymorphisms would result in the development of potential diagnostic and therapeutic possibilities in potentially malignant and malignant lesions.

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“…Oral squamous cell carcinoma (OSCC) is the 6th most common cancers worldwide (Kadashetti et al 2015, Coelho 2012) and 3rd most common cancers in developing countries (Fazeli et al 2011). It ranks among the most common carcinomas, contributing to one third of all body cancers in most of the South Asian countries like India, Bangladesh, Pakistan and Sri Lanka (Atkinson et al 1964).…”

Section: Introductionmentioning

confidence: 99%

Arsenic in HPV Related Oral Carcinoma- A New Threat of the Decade

Pal

Halder

2018

IJMSCI

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Oral/oropharyngeal carcinoma is one of the most common cancers worldwide, ranking 3 rd in developing countries. In India (West Bengal), it ranks first among all other cancers. Its association with different addictions has already been well established worldwide. Another alarming correlation between human papilloma virus (HPV) infection and oral carcinoma has become a new headache of the clinicians all over the world. In India, few studies are showing this relation of HPV in oral carcinoma. Moreover, a new emerging risk factor is metal toxicity. Various metals have been associated with the development of different cancers. Among these, arsenic is a proven carcinogen. Its toxicity is associated with various cancers worldwide, mainly skin, lung and bladder cancer. But, its relation with oral carcinoma is only being stated in a few studies. In India, only one study in West Bengal has shown this correlation so far, because West Bengal is the most arsenic affected area in this country. However, no study has been done correlating metal (arsenic) toxicity, HPV infection in the development of oral carcinoma worldwide; except one in India, stating the correlation among these two factors with oral carcinoma. So, we have tried to carry out the literature survey from all relevant articles in various newspapers and published research papers in Pubmed, Pubmed Central and Google, in order to bring out a review in this field. To our best knowledge, this is the first ever review work involving arsenic toxicity, human papilloma virus infection and oral carcinoma.

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Analysis of various risk factors affecting potentially malignant disorders and oral cancer patients of Central India

Abstract: Chewing tobacco/betel quid is a strong risk factor in the development of PMD and oral cancer. Also age, gender, SES, education, and occupation influence the development of PMD and oral cancer.

Cited by 35 publications

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Multi‐ethnic variations in the practice of oral cancer risk habits in a developing country

Multi‐ethnic variations in the practice of oral cancer risk habits in a developing country

A study on genetic polymorphism in Matrix Metalloproteinases-3 in oral submucous fibrosis patients and in healthy individuals

Arsenic in HPV Related Oral Carcinoma- A New Threat of the Decade

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