Worldwide oral cancer stands sixth among the most devastating cancer types. Oral submucous fibrosis (OSMF), a chronic inflammatory condition of oral mucosa is characterized by fibrosis of lamina propria and connective tissue. OSMF is wildly instituted in India as a consequence of areca nut chewing habits. 1,2 Areca nut chewing causes fibrosis due to increased collagen production and reduced collagen metabolism in extracellular matrix (ECM) of the oral mucosa.However, not all areca chewers develop the disease which enlightens the fact that the disease is not necessarily dose-response related besides the genetic predisposition which might explain such individual erraticism. 3,4 Termination of areca chewing does not affect the characteristics of the disease when established once. 5 Collagen is the most abundant protein synthesized as procollagen in the endoplasmic reticulum. In the folding of type I collagen, three chains [two α1(I) and one α2(I)] first associate at C-terminal propeptides, and approximately 340 repeats of Xaa-Yaa-Gly triplet