Analysis of tramadol in pharmaceutical preparations by high performance thin layer chromatography

Meyyanathan, S. N.; Kumar, Pradeep; Suresh, B.

doi:10.1002/jssc.200301541

Cited by 14 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…System suitability tests, an integral part of a chromatographic analysis was used to verify that the resolution and reproducibility of the chromatographic system are adequate for the analysis [39]. A system suitability test according to USP was performed on the chromatograms obtained from standard and test solutions to check different above-mentioned parameters and the results obtained from six replicate injections of the standard solution are summarized in Table 1.…”

Section: System Suitabilitymentioning

confidence: 99%

Simultaneous determination of albendazole and praziquantel in rat plasma by HPLC-UV

Shah

Dey

Kant

et al. 2017

Proceedings of the 21st International Electronic Conference on Synthetic Organic Chemistry

View full text Add to dashboard Cite

INTRODUCTIONThe most common helminthic disease of the nervous system is nee is the most common helminthic disease of the nervous system, is neurocysticercosis, which is considered as a serious public health problem in developing countries of Latin America, Asia and Africa [1][2][3]. The use of both the drugs Albendazole [ABZ] and Praziquantel [PRQ] consider an effective against the cystic larvae for the treatment of neurocysticercosis over the last 20 years with the use of both the drugs ABZ & PRQ. ABZ has been found an effective drug of choice than PRQ, but this persistence of cysts even after continuous use of ABZ [2]. For the patients, who were the persistence of cyst after the use of ABZ, an alternative treatment therapy was developed where there was simultaneous use of PRQ and ABZ has been evaluated [4][5]. Albendazole and Praziquantel in combination were used extensively for human hydatid disease [6][7][8][9]. Albendazole [ABZ] is an inactive moiety but it readily gets metabolized to an active metabolite Albendazole sulfoxide [ABZSO] then this ABZSO is then further metabolized to an inactive metabolite Albendazole sulfone [ABZSO2] [10]. As ABZ is metabolized extensively, therefore, the plasma concentration of ABZ is also very low as a result the pharmacokinetic studies were been done using Albendazole sulfoxide [ABZSO] as an active metabolite and Albendazole sulfone [ABZSO2] as an inactive metabolite [11][12][13][14][15]. Metabolism of Praziquantel [PRQ] occurs giving a number of hydroxylated metabolites [16][17][18], among which the active metabolite is mainly trans-4-hydroxypraziquantel [TRANS], an active metabolite [19]. Evaluation and the determination of various pharmacokinetic parameters of ABZ and PRQ, the method has been developed

show abstract

Section: System Suitabilitymentioning

confidence: 99%

Simultaneous determination of albendazole and praziquantel in rat plasma by HPLC-UV

Shah

Dey

Kant

et al. 2017

Proceedings of the 21st International Electronic Conference on Synthetic Organic Chemistry

View full text Add to dashboard Cite

show abstract

“…Several methods have also been used for the determination of tramadol, high performance thin layer chromatography [22], simple spectrophotometric [23], tramadol and its metabolites in blood were identified in drugs-related deaths [24], and in combination with morphine as a percentage of opioid analgesic items [25]. Spectrophotometric determination of tramadol in pharmaceutical dosage forms was also achieved [26].…”

Section: Tramadol -Hcl (±Cis-2-[(dimethyl Amino) Methyl]-1-(m-mentioning

confidence: 99%

Simultaneous Determination of Paracetamol and Tramadol in Pharmaceutical Tablets by Derivative UV-Vis Absorption Spectrophotometry

El-Zinati¹,

Abdel-Latif²

2015

TOACJ

View full text Add to dashboard Cite

Abstract:A comparative study of the use of first derivative zero order crossing spectra for the resolution of Paracetamol and Tramadol hydrochloride in mixtures has been achieved showing the success of the first derivative method in resolving and quantifying both compounds. Using the first derivative, rather than the second derivative, results in improved signal to noise ratio. The absorption spectra of prepared mixtures were scanned in the range of 200-500 nm. The linear concentration ranges were 25-112 and 6-48 µg mL -1 for paracetamol and Tramadol hydrochloride, respectively. The method has been successfully used for prediction of concentrations of both compounds in mixtures with good selectivity, high sensitivity and extremely low relative error. Statistical comparison was performed using t-test at 95% confidence level. There was no significant statistical difference between the results obtained by the first derivative method and the accepted values for both compounds. Also, the percentage errors were very low which adds to the merits of our work in terms of both sensitivity and accuracy.

show abstract

“…Multiple analytical procedures have been reported for the analysis of FNS in pharmaceutical preparations when it is present as a single active ingredient or in combination dosage forms, using spectrophotometry (10)(11)(12), thin-layer chromatography (13,14), infrared spectrophotometry (15), polarography (16), voltammetry (17), gas chromatography (18), gas chromatography-mass spectrometry (19), high performance liquid chromatography (HPLC) (20)(21)(22)(23), and ultra-high performance liquid chromatography (UH-PLC) (24,25).…”

Section: Fns Is N-(11-dimethylethyl)-3-oxo-4-aza-5α-androst-1-ene-17mentioning

confidence: 99%

A Dissolution Test for Finasteride in Immediate-Release Capsules

Santos¹,

Santos²,

Pereira³

et al. 2013

Dissolution Technol.

View full text Add to dashboard Cite

In vitro dissolution tests for solid oral dosage forms are extremely important to ensure the quality of these products. However, no dissolution test has been reported for finasteride (FNS) in immediate-release capsules. The aims of this work were to optimize a dissolution method for FNS capsules, validate the analytical method, and evaluate three different commercial products. The best in vitro dissolution profile was achieved using water as the dissolution medium with a basket stirrer at 100 rpm. The quantitative determination was performed by high performance liquid chromatography (HPLC) at 210 nm. All validation parameters were satisfactory. The application of the method to commercial products showed the discriminatory power of the dissolution method. Because there is no monograph for FNS in capsules, this study illustrates the importance of an official dissolution test for FNS in capsules and the need to standardize the composition of the excipients contained in these commercial products.

show abstract

Analysis of tramadol in pharmaceutical preparations by high performance thin layer chromatography

Cited by 14 publications

References 9 publications

Simultaneous determination of albendazole and praziquantel in rat plasma by HPLC-UV

Simultaneous determination of albendazole and praziquantel in rat plasma by HPLC-UV

Simultaneous Determination of Paracetamol and Tramadol in Pharmaceutical Tablets by Derivative UV-Vis Absorption Spectrophotometry

A Dissolution Test for Finasteride in Immediate-Release Capsules

Contact Info

Product

Resources

About