Simultaneous Determination of Paracetamol and Tramadol in Pharmaceutical Tablets by Derivative UV-Vis Absorption Spectrophotometry

El-Zinati, Ahmad M.; Abdel-Latif, Monzir S.

doi:10.2174/1874065001508010001

Cited by 16 publications

(3 citation statements)

References 30 publications

(25 reference statements)

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“…The presence of tramadol can be determined in a variety of pharmaceutical products and biological materials through the use of certain analytical techniques, the use of which has been thoroughly researched and documented using UV-spectrophotometry [ 23 – 25 ], fluorescence spectroscopy [ 26 ], liquid chromatography-tandem mass spectrometry [ 27 ] gas chromatography-mass spectrometry (GC-MS) [ 28 ], capillary electrophoresis with electrochemiluminescence (CE-CL) [ 29 ], FT-Raman [ 30 ], voltammetry [ 31 ], can be found in the literature. Simultaneous quantitative analysis of tramadol, paracetamol, and their combinations were performed by using reverse-phase high-performance liquid chromatography [ 32 , 33 ], ultra-high-performance liquid chromatography (U-HPLC) [ 34 ], UV-spectrophotometry [ 35 , 36 ], spectrophotometric and spectrofluorometric methods [ 37 ], normal phase liquid chromatography-tandem mass spectrometry [ 38 , 39 ] and FTIR [ 40 ] methods have been studied and reported.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric quantification of paracetamol and tramadol hydrochloride by chemometric calibration methods

SELİMOĞLU,

PINARCIK

2023

Turkish Journal of Chemistry

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The results of UV spectrophotometric analysis were analysed using partial least squares (PLS) and principal component regression (PCR) techniques to allow simultaneous evaluation of tramadol hydrochloride (TRA) and p-acetaminophen (PAR) in tablets. A calibration set of 16 mixtures, each containing PAR and TRA in various amounts, was created using a 2 4 -full fractional design. The absorbance data set for the calibration set were obtained between 215–280 nm (Δλ = 0.1 nm). Subsequently, the concentration and absorbance sets were used to generate PCR and PLS calibrations. The ratio spectra- first derivative method was devised as a solution to the same problem to compare the outcomes of the chemometric methods used for the same experiment. After the proposed methods were shown to be accurate in the testing of validation samples, they were used in analysing commercial tablet samples. The analytical results showed that PCR and PLS methods can be used as alternative methods to high-performance liquid chromatography (HPLC). Correlation coefficients were determined for the working concentration range of 6–36 g.mL −1 for PAR and 4–22 g.mL −1 for TRA. The limits of detection and quantification were calculated as 0.9104 μg.mL −1 and 3.0347 μg.mL −1 , respectively. The test results of the chemometric analyses and ratio spectra- first derivative method of the commercial tablet form are in agreement with the results of the one-way ANOVA with a confidence interval of 95%. This study shows that the ratio spectra- first derivative method, PCR and PLS models based on spectrophotometric measurements are very useful and straightforward techniques for the quantitative resolution of a two-component pharmaceutical preparation, requiring little sample preparation and little time for analysis.

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Section: Introductionmentioning

confidence: 99%

Spectrophotometric quantification of paracetamol and tramadol hydrochloride by chemometric calibration methods

SELİMOĞLU,

PINARCIK

2023

Turkish Journal of Chemistry

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“…Paracetamol (acetaminophen) (PC) is widely used as a pain reliever and a fever reducer. Many analytical techniques have been used for PC analysis including titrimetry [13][14], HPLC [15][16][17], fluorometry [18], Uv-visible spectrophotometric methods [19], colorimetry [20] and various modes of electrochemistry [21][22][23][24]. Since the results of above approaches are not accurate and the techniques involved are tedious and expensive, researchers have shown interest to detect the PC through nanocomposites modified carbon paste electrode.…”

Section: Introductionmentioning

confidence: 99%

CuCrO4 Nanoparticles Composite Modiﬁed Carbon Paste Electrodes for Sensitive Detection of Paracetamol: A Cyclic Voltammetric Study

Priyanka¹,

K.P²

2021

Preprint

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An electrochemical sensor containing carbon paste electrode (CPE) for paracetamol is developed and modified with the CuCrO4 Nanocomposites. The synthesised CuCrO4 Nanocomposites was discussed with X-Ray Diffraction studies. Experimental studies such as scan rate, concentration and pH was studied by using cyclic voltammetric method. The CuCrO4 Nanocomposites modified CPE (CuCrO4 Nanocomposites MCPE) exhibited excellent electrocatalytic response towards the oxidation of paracetamol (PC). Over potential for oxidation of PC was minimised which considerably enhance the current response on the CuCrO4 Nanocomposites MCPE when compared with bare carbon paste electrode (BCPE). Scan rate study for PC discuss the process of the electrode. Linear calibration curve was obtained with the range of 2 μM to 14 μM having the detection limit and quantification limit value of PC is discussed with CuCrO4 Nanocomposites MCPE. This study shows that electrochemical oxidation of PC at CuCrO4 Nanocomposites MCPE is pH dependent process.

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“…It is often the analgesic or antipyretic of choice in asthmatic patients, those with a history of peptic ulcer, and in children 2,3 . Recently Literature survey has revealed some analytical methods for the determination of PAR either individually or in other combination such as spectrophotometry 4,5 , voltametry 6 and HPLC 7,8 . Chlorzoxazone (CXZ) is 5-Chloro-2(3H)benzoxazolone a centrally active muscle relaxant.…”

Section: Introductionmentioning

confidence: 99%

Efficient processing of Single and Multiple Spectral Variables for Resolution and Quantitation of Paracetamol, Chlorzoxazone and Diclofenac

Hegazy

Elshahed

Toubar

et al. 2018

Journal of Advanced Pharmacy Research

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Objectives: The main aim of this study is to apply smart, simple, rapid and accurate methods for simultaneous determination of Paracetamol (PAR), Chlorzoxazone (CXZ) and Diclofenac potassium (DIC), in their bulk powder and tablet dosage form. Methods: Potent processing methods were used which were based on the application of continuous wavelet transform (CWT) and Savitsky-Golay derivatization (SAVGOL) as univariate spectrophotometric methods, partial least squares (PLS) and synergy interval partial least squares (siPLS) as multivariate methods. Results: PAR, CXZ and DIC were determined in the concentration ranges of 2-30, 2-50 and 2-30 μg mL-1 , respectively. The regressing and validation parameters of the proposed methods revealed the efficiency of the methods. The results obtained for the analysis of those drugs by the proposed methods were statistically compared to those obtained by applying a reported high performance liquid chromatographic method. Statistical comparison was done, and no significant difference was found between the proposed methods and the reported one. Conclusion: Successful determination of ternary mixture containing PAR, CXZ and DIC was achieved with no need for tedious sample separation or pre-treatment derivatization which is considered a great benefit in quality control laboratories.

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Simultaneous Determination of Paracetamol and Tramadol in Pharmaceutical Tablets by Derivative UV-Vis Absorption Spectrophotometry

Cited by 16 publications

References 30 publications

Spectrophotometric quantification of paracetamol and tramadol hydrochloride by chemometric calibration methods

Spectrophotometric quantification of paracetamol and tramadol hydrochloride by chemometric calibration methods

CuCrO4 Nanoparticles Composite Modiﬁed Carbon Paste Electrodes for Sensitive Detection of Paracetamol: A Cyclic Voltammetric Study

Efficient processing of Single and Multiple Spectral Variables for Resolution and Quantitation of Paracetamol, Chlorzoxazone and Diclofenac

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