2023
DOI: 10.55730/1300-0527.3566
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Spectrophotometric quantification of paracetamol and tramadol hydrochloride by chemometric calibration methods

FAYSAL SELİMOĞLU,
NERMİN PINARCIK

Abstract: The results of UV spectrophotometric analysis were analysed using partial least squares (PLS) and principal component regression (PCR) techniques to allow simultaneous evaluation of tramadol hydrochloride (TRA) and p-acetaminophen (PAR) in tablets. A calibration set of 16 mixtures, each containing PAR and TRA in various amounts, was created using a 2 4 -full fractional design. The absorbance data set for the calibration set were obtained between 215–280 nm (Δλ = 0.1 nm). Subsequently, th… Show more

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