Analysis by gas chromatography–mass spectrometry of the volatile components of Teucrium lusitanicum and Teucrium algarbiensis

Cavaleiro, Carlos; Salgueiro, Lı́gia; Miguel, Maria Graça; Cunha, A. Proença da

doi:10.1016/j.chroma.2004.01.005

Cited by 67 publications

(37 citation statements)

References 13 publications

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“…The oil was less effective against Aspergillus strains (Table 1). The higher susceptibility of dermatophytes has also been reported for other essential oils (Salgueiro et al, 2004;Pinto et al, 2006Pinto et al, , 2009Zuzarte et al, 2009).…”

Section: Antifungal Activity Of the Essential Oilsmentioning

confidence: 72%

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Chemical composition and antifungal activity of the essential oils of Lavandula viridis L'Hér.

Zuzarte

Gonçalves

Cavaleiro

et al. 2011

Journal of Medical Microbiology

120

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In the present work we report for what we believe to be the first time the antifungal activity and mechanism of action of the essential oils of Lavandula viridis from Portugal. The essential oils were isolated by hydrodistillation and analysed by GC and GC/MS. The MIC and the minimal lethal concentration (MLC) of the essential oil and its major compounds were determined against several pathogenic fungi. The influence of subinhibitory concentrations of the essential oil on the dimorphic transition in Candida albicans was also studied, as well as propidium iodide and FUN-1 staining of Candida albicans cells by flow cytometry following short treatments with the essential oil. The oils were characterized by a high content of oxygen-containing monoterpenes, with 1,8-cineole being the main constituent. Monoterpene hydrocarbons were present at lower concentrations. According to the determined MIC and MLC values, the dermatophytes and Cryptococcus neoformans were the most sensitive fungi (MIC and MLC values ranging from 0.32 to 0.64 ml ml "1 ), followed by Candida species (at 0.64-2.5 ml ml "1 ). For most of these strains, MICs were equivalent to MLCs, indicating a fungicidal effect of the essential oil. The oil was further shown to completely inhibit filamentation in Candida albicans at concentrations well below the respective MICs (as low as MIC/16). Flow cytometry results suggested a mechanism of action ultimately leading to cytoplasmic membrane disruption and cell death. Our results show that L. viridis essential oils may be useful in the clinical treatment of fungal diseases, particularly dermatophytosis and candidosis, although clinical trials are required to evaluate the practical relevance of our in vitro research.

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Section: Antifungal Activity Of the Essential Oilsmentioning

confidence: 72%

“…The oils were preserved in a sealed vial at 4 uC. Oil analyses were carried out by both GC and GC/MS using fused silica capillary columns with two different stationary phases (SPB-1 and SupelcoWax-10) as previously reported (Cavaleiro et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

Chemical composition and antifungal activity of the essential oils of Lavandula viridis L'Hér.

Zuzarte

Gonçalves

Cavaleiro

et al. 2011

Journal of Medical Microbiology

120

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“…1 Some of them have been used as medicinal plants since time immemorial and are still being used in folk medicine as antispasmodics, tonics, antipyretics and antiseptics. 2,3 However, several publications have indicated the hepatotoxic effect when the decoction of the aerial parts of some Teucrium spp. are used in herbal medicine, probably due to the diterpenoids involved; [4][5][6][7] this class of terpenoids has in general shown insect antifeedant activity.…”

Section: Introductionmentioning

confidence: 98%

“…are used in herbal medicine, probably due to the diterpenoids involved; [4][5][6][7] this class of terpenoids has in general shown insect antifeedant activity. 2,[8][9][10] So far, essential oils have been reported from the aerial parts of several Teucrium spp. The essential oil content varies (0.5-1.5%) in different species growing in different parts of the world, and the percentage of the major chemical constituents (mainly monoterpene/ sesquiterpene hydrocarbons and oxygenated sesquiterpenes) invariably differ from species to species.…”

Section: Introductionmentioning

confidence: 99%

Composition and antioxidant activity of the essential oil of Teucrium royleanum Wall. ex Benth growing in Pakistan

Saroglou

Arfan

Shabir

et al. 2006

Flavour & Fragrance J

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The chemical composition of the essential oil obtained from the leaves of Teucrium royleanum, growing in Pakistan, was investigated by GC-MS analyses. Kováts indices, mass spectra and standard compounds were used to identify a total of 46 individual compounds. Sesquiterpene hydrocarbons formed the main portion (42.2%) of the oil, among which β β β β β -santalene and cis-α α α α α-bisabolene were the predominant compounds. The potential antioxidant activity was also investigated and the sample tested was found to interact slightly with the stable free radical DPPH in a timedependent manner.

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“…The oils were preserved in a sealed vial at 4 uC. Oil analyses were carried out both by GC with flame-ionization detector (GC-FID) and by GC-MS using fused silica capillary columns with two different stationary phases (SPB-1 and SupelcoWax-10) as previously reported (Cavaleiro et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

Correlation of the chemical composition of essential oils from Origanum vulgare subsp. virens with their in vitro activity against pathogenic yeasts and filamentous fungi

Vale-Silva

Silva

Hartwig

et al. 2012

Journal of Medical Microbiology

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Analysis by gas chromatography–mass spectrometry of the volatile components of Teucrium lusitanicum and Teucrium algarbiensis

Cited by 67 publications

References 13 publications

Chemical composition and antifungal activity of the essential oils of Lavandula viridis L'Hér.

Chemical composition and antifungal activity of the essential oils of Lavandula viridis L'Hér.

Composition and antioxidant activity of the essential oil of Teucrium royleanum Wall. ex Benth growing in Pakistan

Correlation of the chemical composition of essential oils from Origanum vulgare subsp. virens with their in vitro activity against pathogenic yeasts and filamentous fungi

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