Composition and antioxidant activity of the essential oil of Teucrium royleanum Wall. ex Benth growing in Pakistan

Saroglou, Vasiliki; Arfan, Muhammad; Shabir, Anam; Hadjipavlou‐Litina, Dimitra; Skaltsa, Helen

doi:10.1002/ffj.1774

Cited by 43 publications

(16 citation statements)

References 25 publications

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“…Also, essential oils have been reported from the aerial parts of several Teucrium spp. The oils showed different yields in the various species, ranging between 0.5% and 1.5%, and the percentage of the major chemical constituents (mainly monoterpene/sesquiterpenes hydrocarbons and oxygenated sesquiterpenes) differs notably from species to species (Saroglou et al, 2007). Rhazya stricta Decne (Harmal), a member of Apocynaceae family, is an important medicinal species used in folkloric medicine to cure various diseases in South Asia and in the Middle East (Gilani et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Biochemical and histological evidences for the antitumor potential of Teucrium Oliverianum and Rhazya stricta in chemically-induced hepatocellular carcinoma

Shahat¹,

Alsaid²,

Kotob³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: Teucrium oliverianum and Rhazya stricta are medicinal plants used in traditional and herbal medicine for the treatment of diabetes, liver diseases and inflammatory conditions. The present study was planned to investigate the antitumor efficacy of Teucrium oliverianum and Rhazya stricta in chemically-induced hepatocellular carcinoma (HCC) in rats. Materials and Methods: Forty adult male rats weighing 170-200 g were divided into four groups; each group was comprised of ten rats: (1): Normal healthy animals served as negative control group, (2): Hepatocellular carcinoma (HCC) group in which the rats were orally administered Nnitrosodiethylamine (dissolved in 0.9% normal saline), in a dose of 20 mg/kg b.wt. five times a week for six weeks, (3): HCC group treated with Teucrium oliverianum extract in a dose of 600 mg/kg b.wt for two months and (4): HCC group treated with Rhazya stricta extract in a dose of 750 mg/kg b.wt for two months. Serum alanine aminotransferase (ALT), asparatate aminotransferase (AST), alkaline phosphatase (ALP) and gammaglutamyl transferase (γ-GT) activities were estimated. Serum carcinoembyronic antigen (CEA), alpha-fetoprotein (AFP), alpha-L-fucosidase (AFU), glypican-3 (GPC-3), golgi protein 73 (Gp-73) and vascular endothelial growth factor (VEGF) levels were determined. Histopathological examination of liver tissue sections was also carried out. Results: The HCC group showed significant elevation in serum AST, ALT, ALP and γ-GT activities as well as CEA, AFP, AFU, Gpc-3, Gp 73 and VEGF levels versus the negative control group. Photomicrograph of liver tissue sections of rats in HCC revealed hepatic parenchyma with foci of anaplastic hepatocellular carcinoma as well as other foci of cystic cholangio carcinoma associated with areas of telangictasis with haemorrhage as well as individual hepatocellular necrosis. Conclusion: Treatment of HCC groups with Teucrium oliverianum or Rhazya stricta extract experienced significant improvement in the measured biochemical parameters as well as in the structural organization of the liver. In conclusion, the current study provided experimental evidences for the antitumor efficacy of Teucrium oliverianum and Rhazya stricta against hepatocellular carcinoma. Such effect could be attributed to hepatoprotective properties, antiproliferative activity and antiangiogenic potential.

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Section: Introductionmentioning

confidence: 99%

Biochemical and histological evidences for the antitumor potential of Teucrium Oliverianum and Rhazya stricta in chemically-induced hepatocellular carcinoma

Shahat¹,

Alsaid²,

Kotob³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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“…More than 220 diterpenes have been described to date, many of which are particularly interesting because of their ecological role as antifeedants against different species of insects and of their role in the medicinal properties of the plants [6]. So far, essential oils have been also reported from the aerial parts of several Teucrium species [7][8][9][10].…”

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confidence: 99%

Chemical Composition and Phytotoxic Effects of Essential Oils from Four Teucrium Species

Martino

Formisano

Mancini

et al. 2010

Natural Product Communications

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The essential oils of four Teucrium species were studied and 131 components, in all, were identified. All oils were rich in sesquiterpenes (50.0-61.9%). Caryophyllene and caryophyllene oxide were the main components of Teucrium arduini; germacrene D, δ-cadinene and γ-cadinene predominated in Teucrium maghrebinum. Carvacrol and caryophyllene predominated in Teucrium polium ssp. capitatum, while carvacrol, caryophyllene oxide and caryophyllene were the most abundant components in Teucrium montbretii ssp. heliotropiifolium. The germination of radish and garden cress was less sensitive to the four essential oils. The radicle elongation, above all, of radish was significantly inhibited by all oils, in particular by the essential oil of T. arduini, at the highest doses tested. Among the main components of the oils, monoterpenes resulted the more active compounds.

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“…From the nonpharmacologic perspective, Maccioni et al (2007) has noted the importance of Teucrium species as edible plants, as some of them are currently used in the preparation of flavored wines, herbal teas, bitters, and liqueurs; infusions of the leaves and flowers are used for flavoring beers in some areas. The importance of this genus in the food industries lies also in the fact that many species display anti-microbial, anti-oxidant, and anti-fungal activities, rendering them useful as natural preservative ingredients (Ulubelen et al, 2000;Özkan et al, 2007;Saroglou et al, 2007).…”

Section: Research Articlementioning

confidence: 99%

In vitroandin vivoimmunomodulatory and anti-ulcerogenic activities ofTeucrium ramosissimumextracts

Sghaïer¹,

Krifa²,

Mensi³

et al. 2011

Journal of Immunotoxicology

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Composition and antioxidant activity of the essential oil of Teucrium royleanum Wall. ex Benth growing in Pakistan

Cited by 43 publications

References 25 publications

Biochemical and histological evidences for the antitumor potential of <i>Teucrium Oliverianum</i> and <i>Rhazya stricta</i> in chemically-induced hepatocellular carcinoma

Biochemical and histological evidences for the antitumor potential of <i>Teucrium Oliverianum</i> and <i>Rhazya stricta</i> in chemically-induced hepatocellular carcinoma

Chemical Composition and Phytotoxic Effects of Essential Oils from Four Teucrium Species

In vitroandin vivoimmunomodulatory and anti-ulcerogenic activities ofTeucrium ramosissimumextracts

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