“…Compared with charge coupled device (CCD), complementary metal oxide semiconductor (CMOS) image sensor has advantages of readout frame rate, cost, and power, which is now extensively used in consumer, surveillance, industrial applications. For scientific imaging, the image sensor needs to deliver high sensitivity [1,2], high frame rate [3,4,5,6,7,8,9] and low noise [10,11,12,13,14,15]. Scientific CMOS image sensors (sCMOS) can provide high sensitivity, high speed, and low noise simultaneously.…”