ANALGETIC ACTIVITY OF CEP-CEPAN (Saurauia  cauliflora DC.) LEAVES EXTRACT

Salim, Emil; Fatimah, Cut; Fanny, Dewi Yul

doi:10.24815/jn.v17i1.6856

Cited by 6 publications

(6 citation statements)

References 3 publications

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“…26 According to Salim et al 2017, the dried Saurauia cauliflora leaves contained flavonoids, alkaloids, tannins, anthraquinone glycosides and steroids/triterpenoids. 27 Results of phytochemical screening on simplisia and ethanol Saurauia vulcani extract were essentially similar. Both items showed the presence of flavonoid, glycosides, saponins, tannins and steroids/ triterpenoids 22 .…”

Section: Phytochemical and Toxicitymentioning

confidence: 82%

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A Review on Genus Saurauia: Chemical Compounds and their Biological Activity

Pasaribu

Budianto²,

Cahyana

et al. 2020

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Introduction: Saurauia plant has been widely used to treat a variety of diseases suffered by villagers at various places in the world. These species are widely used traditionally by the community as antidiabetic and digestive problems' remedy. This paper will present various uses and researches ever carried out by researchers in the world on various types of the genus Saurauia. Methods: The Information was collected from scientific journals, books, and reports. Results: This review summarizes the existing information on several species of Saurauia in relation to their chemical compounds and biological activity. There are some of chemical compounds present and identified in Saurauia, i.e. 3β-hydroxy-Olean-12-en-28oic acid; 3,19-Dihydroxyurs-12-en-28-oic acid; 3-hidroksi, 12(13)-en, 28-oleanolat acid; actinidin; several monoterpene lactones; seven triterpenoids, namely, cis-3-O-p-hydroxycinnamoyl ursolic acid; trans-3-O-p-hydroxycinnamoyl ursolic acid; ursolic acid; oleanolic acid; corosolic acid; maslinic acid; and β-amyrin; and two steroids, stigmasterol; and β-sitosterol. There are several biological activities afforded by Saurauia i.e. antioxidant activity, anti-cholesterol, antidiabetic activity, antihyperlipidemic, analgetic activity, antimicrobial activity, wound-healing activity and immunostimulatory activity.

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Section: Phytochemical and Toxicitymentioning

confidence: 82%

“…The analgesic test results showed that the leaves' extract at the dose of 250 mg/kgBW brought about strong analgesic effect which was similar to that of the same extract at 500 mg/kgBW and that of antalgin at 65 mg/kgBW. 27…”

Section: Analgetic Activitymentioning

confidence: 99%

A Review on Genus Saurauia: Chemical Compounds and their Biological Activity

Pasaribu

Budianto²,

Cahyana

et al. 2020

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“…Indonesia memiliki keanekaragaman hayati hutan terbesar kedua di dunia, dengan 28.000 spesies tanaman, di mana 2.500 spesies, termasuk Castanopsis costata, umumnya dikenal sebagai "Cep cepan", digunakan sebagai obat [10]. C. costata termasuk dalam famili Fagaceae dan telah dikenal memiliki aktivitas terapeutik sebagai anti demam, meringankan masalah pencernaan dan analgesik [11]. Hasil penelitian terbaru saat ini telah melaporkan bahwa daun C. costata mempunyai efek antipiretik yang di uji secara in vivo [12].…”

Section: Pendahuluanunclassified

Pemanfaatan Tumbuhan Cep-cepan (Castanopsis costata) Sebagai Terapi Adjuvan Demam Di Madrasah Ibtidaiyah Al Istianah Karawang

Alkandahri,

Arfania,

Yuniarsih

et al. 2023

MJM

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Demam adalah tanda klinis umum yang ditandai dengan kenaikan suhu tubuh di luar batas normal. Strategi dalam menangani demam adalah dengan mencari senyawa antipiretik baru pada tumbuhan obat. Hampir semua obat antipiretik saat ini memblokir sintesis PGE2 melalui penghambatan enzim siklooksigenase-2 (COX-2). Selain itu, agen sintetik ini secara ireversibel menghambat COX-2 dengan selektivitas tinggi, sehingga bersifat toksik bagi sel hati, glomeruli, korteks otak dan otot jantung. Sementara itu, telah dilaporkan bahwa inhibitor COX-2 alami memiliki efek samping yang relatif lebih sedikit. Tumbuhan cep-cepan (Castanopsis costata (Blume) A.DC.) yang merupakan famili Fagaceae sering digunakan sebagai obat antipiretik oleh masyarakat suku Karo di Medan, Sumatera Utara, namun penggunaannya masih bersifat turun-temurun. Tujuan kegiatan ini adalah untuk memberikan pengetahuan kepada masyarakat mengenai Pemanfaatan Tumbuhan Cep-cepan (Castanopsis costata) Sebagai Terapi Adjuvan Demam. Kegiatan pengabdian kepada masyarakat ini dilakukan pada Sabtu, 4 Maret 2023 dengan menggunakan metode edukasi/ceramah langsung kepada masyarakat. Bedasarkan hasil penyuluhan ini, didapatkan hasil bahwa semua siswa/i telah mengetahui tentang demam, pengobatan demam, dan manfaat tumbuhan cep-cepan sebagai terapi adjuvan demam. Diharapkan setelah mengikuti penyuluhan ini, siswa/i MI Al Istianah dapat mengaplikasikan ilmu yang telah diberikan kepada diri sendiri dan keluarga.

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“…6 In the Fagaceae family, C. costata leaves are traditionally useful for the treatment of abdominal pain, diarrhea, fever and other health conditions. [7][8] Apart from the therapeutic uses of this plant for diarrhea and abdominal pain, it has been reported to have antioxidant, 9 antihyperlipidemic, 8 and antidiabetic activities. 5 Pharmacognosy Journal, Vol 15, Issue 1, Jan-Feb, 2023…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antidiarrheal, Antispasmodic, and Antisecretory Activities of Extract and Fractions of Castanopsis costata Leaves in Animal Models

Alkandahri¹,

Sholih²,

Fadilah³

et al. 2023

Pharmacogn J.

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Several studies found that diarrhea damages the intestinal antioxidant defense system, culminating in further complications and other oxidative stress disorders. Therefore, antioxidants can play an important role in the management of diarrhea. [10][11] There are currently no detailed investigations on the antidiarrheal phytoconstituents of C. costata, but it is known to contain alkaloids, flavonoids, tannins, steroids, and others, which majorly have antidiarrheal activities. 8,12 Therefore, this study aims to evaluate the antidiarrheal, antispasmodic, and antisecretory activities of extract and fractions of the C. costata leaves using an animal model of castor oilinduced diarrhea.

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ANALGETIC ACTIVITY OF CEP-CEPAN (Saurauia cauliflora DC.) LEAVES EXTRACT

Cited by 6 publications

References 3 publications

A Review on Genus Saurauia: Chemical Compounds and their Biological Activity

A Review on Genus Saurauia: Chemical Compounds and their Biological Activity

Pemanfaatan Tumbuhan Cep-cepan (Castanopsis costata) Sebagai Terapi Adjuvan Demam Di Madrasah Ibtidaiyah Al Istianah Karawang

Evaluation of Antidiarrheal, Antispasmodic, and Antisecretory Activities of Extract and Fractions of Castanopsis costata Leaves in Animal Models

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