Analgesic and antihyperglycemic activity evaluation of Bambusa vulgaris aerial parts

Abstract

Bambusa vulgaris, also known as 'Ora Bansh' in Bangladesh is grown throughout the country for housing and scaffolding purposes. As part of our analgesic and antihyperglycemic plants of Bangladesh screening program, it was of interest to evaluate the analgesic and antihyperglycemic potential of aerial parts of the plant. Methanolic extract of aerial parts (MEBV) at doses of 50, 100, 200 and 400 mg per kg significantly reduced the number of writhings in acetic acid-induced pain model Swiss albino mice by 25.9, 29.6, 37.0, and 44.4%, respectively compared to reductions of 40.7 and 51.9%, respectively, obtained with 200 and 400 mg per kg of a standard analgesic drug, aspirin. MEBV, at doses of 100, 200 and 400 mg per kg also significantly lowered blood glucose levels in mice, respectively, by 32.8, 45.8, and 55.3% compared to control mice. A standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg lowered blood glucose level by 50.8%. Taken together, the results indicate that the aerial parts of the plant possess considerable analgesic and antihyperglycemic potential, which can possibly be attributed to the presence of alkaloids and saponins in the extract.

A Pharmacognostic and Pharmacological overview on various Bamboo Species

“…The results are shown in Table 2 and suggest that the methanolic crude extract of MEBS is a potent analgesic extract and can be used for comfort of pain. [7] 2) Antihyperglycemic Agents: Swiss albino mice, which counted between 11-15 g were used for the hypoglycemic potential. The mice were choosen for three days prior to genuine trials.…”

“…Thus MEBS at the highest dose tested showed better antihyperglycemic activity than glibenclamide, and even at a dose of 200 mg per kg showed comparable results to glibenclamaide. [7,8] 3) Antipyretic Activity: Adult healthy masculine wistar rats with body mass of roughly 150 -200 g were used. The subjects used for activity were conditioned at room temperature and at natural photoperiods for 1 week before study.…”