An Unusual Case of Early Malignant Transformation in a Spiradenoma

Herzberg, Arlene J.; Elenitsas, Rosalie; Strohmeyer, Cynthia R.

doi:10.1111/j.1524-4725.1995.tb00281.x

Cited by 20 publications

(30 citation statements)

References 13 publications

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“…The precise identification of a benign or malignant hidradenoma, based on pathological examination, was not possible. Similar findings were noted in other case reports of clear cell hidradenoma [21][22][23][24][25][26] .…”

Section: Discussionsupporting

confidence: 92%

Malignant Nodular Hidradenoma: Isolated Case Report and Review of Literature

Khan

Ali

Ferdousi

et al. 2017

J. Bangladesh Coll. Phys.

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Summary:Malignant Nodular Hidradenoma is an infrequent highly malignant, primary skin tumor derived from eccrine sweat glands. It has an aggressive course, with high recurrence, high rate of metastases and has very poor prognosis. It has been described as an "orphan"neoplasm. The tumor is similar to its benign counterpart but had additional features such as surface ulceration, numerous mitotic figures and infiltrative growth pattern. Pre-operative diagnosis is difficult by the fine needle aspiration cytology. Malignant nodular hidradenoma of chest wall in 35 years old women, who presented to us with a recurrent rapidly growing swelling over chest wall that grew rapidly over two months after first excision. Tissue diagnosis of first excised specimen was eccrine poroma that was similar to its benign counterpart. criteria for malignancy include poor circumscription, presence of nuclear atypia, mitotic activity, presence of predominantly solid cell islands, infiltrative growth pattern, necrosis, and angio-lymphatic permeation 3-5 .We report a case of malignant nodular hidradenoma in a middle aged woman who presented with a recuurent swelling in right side of lower chest wall. Case report :A 35 years old female presented to us with swelling over right side of chest wall. The swelling was excised and sent for histopathology. The report was ecccrine proroma. But it recurred after two months. The swelling was rapidly increasing in size over the last one and half months. The mass became significantly prominent over the last 15 days prior to presentation resulting in discomfort.Physical examination revealed a large lobulated mass about 20 cmx15cm in size, without ulceration. It was hard, non-mobile, non-fluctuant and adherent to the old scar. The draining area showed no palpable lymphnode. General examination including lungs and liver were normal. Per-operatively, a hard fibrous tumor was observed to infiltrate the muscle but not to underlying ribs. Wide local excision with 1 cm marginal clearance of healthy surrounding tissue was performed along with primary closure. Biopsy was sent to pathological examination.

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Section: Discussionsupporting

confidence: 92%

Malignant Nodular Hidradenoma: Isolated Case Report and Review of Literature

Khan

Ali

Ferdousi

et al. 2017

J. Bangladesh Coll. Phys.

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“…In the histopathologic examination of MES, two distinct components are seen: typical benign eccrine spiradenoma and carcinoma with areas of transitions 8 . The carcinoma may show squamous differentiation or sarcomatous change 1,7,14 . Microscopic examination in our case showed only carcinoma, including proliferation of solid masses of tumor cells with large hyperchromatic nuclei and frequent atypical mitoses, invasion of surrounding connective tissue, loss of basement membrane, and squamous differentiation.…”

Section: Discussionmentioning

confidence: 50%

De Novo Malignant Eccrine Spiradenoma with an Interesting and Unusual Location

Yıldırım¹,

Aköz²,

Akan³

et al. 2001

Dermatol Surg

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“…These results are similar to other studies reviewing spiradenocarcinoma from all cutaneous sites. Herzberg et al 13 found local recurrence and metastasis rates at 32% and 44%, respectively, with a disease-specific mortality of 20%. 13 A more recent review placed local recurrence and metastasis rates at 57% and 39%, respectively, with a disease-specific mortality of 39%.…”

Section: Discussionmentioning

confidence: 97%

“…Herzberg et al 13 found local recurrence and metastasis rates at 32% and 44%, respectively, with a disease-specific mortality of 20%. 13 A more recent review placed local recurrence and metastasis rates at 57% and 39%, respectively, with a disease-specific mortality of 39%. 5 Although control of disease has been shown after reexcision of local recurrence, once distant metastasis occurs, death ensues rapidly.…”

Section: Discussionmentioning

confidence: 97%