No abstract

DOI: 10.3329/bjpath.v25i1.4123Bangladesh J Pathol 25(1): 1-2

Summary:Malignant Nodular Hidradenoma is an infrequent highly malignant, primary skin tumor derived from eccrine sweat glands. It has an aggressive course, with high recurrence, high rate of metastases and has very poor prognosis. It has been described as an "orphan"neoplasm. The tumor is similar to its benign counterpart but had additional features such as surface ulceration, numerous mitotic figures and infiltrative growth pattern. Pre-operative diagnosis is difficult by the fine needle aspiration cytology. Malignant nodular hidradenoma of chest wall in 35 years old women, who presented to us with a recurrent rapidly growing swelling over chest wall that grew rapidly over two months after first excision. Tissue diagnosis of first excised specimen was eccrine poroma that was similar to its benign counterpart. criteria for malignancy include poor circumscription, presence of nuclear atypia, mitotic activity, presence of predominantly solid cell islands, infiltrative growth pattern, necrosis, and angio-lymphatic permeation 3-5 .We report a case of malignant nodular hidradenoma in a middle aged woman who presented with a recuurent swelling in right side of lower chest wall. Case report :A 35 years old female presented to us with swelling over right side of chest wall. The swelling was excised and sent for histopathology. The report was ecccrine proroma. But it recurred after two months. The swelling was rapidly increasing in size over the last one and half months. The mass became significantly prominent over the last 15 days prior to presentation resulting in discomfort.Physical examination revealed a large lobulated mass about 20 cmx15cm in size, without ulceration. It was hard, non-mobile, non-fluctuant and adherent to the old scar. The draining area showed no palpable lymphnode. General examination including lungs and liver were normal. Per-operatively, a hard fibrous tumor was observed to infiltrate the muscle but not to underlying ribs. Wide local excision with 1 cm marginal clearance of healthy surrounding tissue was performed along with primary closure. Biopsy was sent to pathological examination.

Gestational Diabetes Mellitus (GDM) is a very common and important disease occurring during pregnancy and has detrimental effect on both the mother and the baby. The mother is at increased risk of developing obstetric complications like prolonged labour, prone to develop type 2 diabetes in future and the baby is born with overweight, cause of childhood obesity and later life development of type 2 diabetes. A short review and current concept of GDM is discussed.

Background and Objectives: Due to geographical position and geological nature, Bangladesh (BD) has been the worst affected country in the world by arsenic contamination. The aim of this study was to highlight the association of chronic arsenic intoxication with thyroid disorders (TDs). Materials and Methods: This cross-sectional study was conducted from March 2019 to February 2020 at Ad-din Women's Medical College and Hospital. One thousand one hundred and thirty-seven patients were randomly selected, who visited the outpatient departments of medicine faculty with thyroid-stimulating hormone test report. Rest of the thyroid function tests were done if required. Considering the arsenic level in irrigation and drinking water, 64 districts of BD were divided into two regions “arsenic prevalent area” and “less arsenic prevalent area” and patients hailing from those areas were divided as Group 1 and Group 2, respectively. All patients were subjected to history taking and physical examination. Chi-square test and one-way ANOVA test were used to compare the variables. Results: Prevalence of TD were significantly higher in Group 1 (60.14%; P = 0.001) and so was the prevalence of goiter (19%;P = 0.021). Older (31.17 ± 9.81;P = 0.001) and female patients (94.92%;P = 0.001) were more prone to develop TD. Conclusion: It will require more studies at larger scale for better understanding of the association of thyroid disorders with chronic arsenic intoxication.