External auditory canal eccrine spiradenocarcinoma: A case report and review of literature

Abstract

Eccrine spiradenocarcinoma is an aggressive tumor with a poor prognosis. Primary treatment should include wide local excision with or without regional lymphadenectomy. Isolated successful treatments have been documented with adjuvant hormonal manipulation, chemotherapy, and radiation therapy.

De Novo Malignant Eccrine Spiradenoma: A Case Report and Review of the Literature

“…16 Multiple synonymous terms including MES, eccrine spiradenocarcinoma, eccrine adenocarcinoma, and sweat gland carcinoma ex-ES have been used to designate these aggressive lesions. 17 More rarely, these lesions may develop de novo. 18 The most recent R, resection; LND, lymph node dissection; Am, amputation; M, mastectomy; C, chemotherapy; HT, hormonal therapy (tamoxifen); ANED, alive with no evidence of disease; DOD, died of disease; DOUD, died of unrelated disease; AWD, alive with disease; NA, data not available.…”

Malignant Eccrine Spiradenoma with Squamoid and Chondroid Differentiation

“…It shows focal squamous differentiation, which may be florid in rare instances. Less frequently, areas of spiradenoma near or in transition with a malignant tumor such as rhabdomyosarcoma, osteosarcoma, leiomyosarcoma, and chondrosarcoma may be present [9,10]. Malignant eccrine spiradenoma exhibit variable expression of cytokeratins, carcinoembryonic antigen, epithelial membrane antigen and S100 protein.…”

Direct Intracranial Extension of Malignant Eccrine Spiradenoma of the Face

“…It is normally considered to be a malignant transformation of a pre-existing benign eccrine spriradenoma [1-3]. MES presents at an average age of 59 years (range: 21-92 years) and shows no sex predilection [4].…”

“…MES has been reported to occur on a traumatized area [9]. Literature review revealed only about 18 reported cases involving the head and neck region [1, 10]. Overall prognosis of malignant eccrine spiradenoma is poor [1].…”

“…In contrast, the malignant eccrine spiradenoma (MES) is an extremely rare tumor, which almost always arises from a pre-existing eccrine spiradenoma. The overall prognosis of malignant eccrine spiradenoma is poor [1]. Our case report describes one such aggressive presentation of MES with direct intracranial extension without distant metastasis.…”