De Novo Malignant Eccrine Spiradenoma with an Interesting and Unusual Location

Abstract

Although previously reported lesions have arisen in long-standing benign ESs, usually on the trunk or extremities, this report shows that MES may occur as a primary malignant tumor and may occur in unusual locations such as the nose.

Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases

“…They express cytokeratins, epitherial membrane antigen and p53. 3 In our case, the pathological features matched these characteristics of MES and the somewhat long clinical course before diagnosis may account for the pre-existing benign eccrine spiradenoma. Because of the limited number of case reports, the management of MES is not evidence-based.…”

“…MES is rare, with only 68 cases reported in the English literature, including 2 Japanese cases, 1 Korean, 1 Taiwanese and 1 African American case. [2][3][4][5][6][7][8] In addition, 15 other cases have been reported in the Japanese literature (Table 1). 9,10 To identify any differences in the clinical features and prognosis between the 19 East Asian and the 63 white cases, we summarized the age at diagnosis, gender, location and prognosis.…”

De Novo Malignant Eccrine Spiradenoma: A Case Report and Review of the Literature

“…In order of decreasing frequency, MES tends to metastasize to regional lymph nodes, lungs, brain, and liver, 18 with documented reports of spread to the skin, spinal cord, and parotid gland. 17,44,56 Studies elaborating treatment options for widespread disease often document poor survival and short periods of follow-up.…”

“…17 More rarely, these lesions may develop de novo. 18 The most recent (Table 1). Histopathologic examination yields the diagnosis in most cases and requires the demonstration of a benign focus within or adjacent to malignant tumor.…”

“…15,16,63 The majority of these high-grade tumors demonstrate areas of abnormal squamous or sarcomatous cellular differentiation. 18 In contrast, the low-grade tumors present more of a diagnostic challenge, with loss of two-cell population pattern characteristic of ES and only mild to moderate pleomorphism with mitotic rates ranging from 2 to 14 per 10 highpower fields. 61 Both low-and high-grade tumors commonly exhibit vascular invasion, a useful histologic indicator of metastatic potential.…”