An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization

Verbanac, Donatella; Jain, Subhash C.; Jain, Nidhi; Chand, Mahesh; Paljetak, Hana Čipčić; Matijašić, Mario; Perić, Mihaela; Stepanić, Višnja; Saso, Luciano

doi:10.1016/j.bmc.2012.03.074

Cited by 20 publications

(11 citation statements)

References 49 publications

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“…A number of studies have been reported describing the anticancer feature of TXs and their derivatives . According to these findings, while aminoalkylthioxanthones, 3‐substituted‐4‐chloro‐thioxanthones and their S, S‐dioxide thioxanthone derivatives, and aza‐thioxanthones exhibited cell growth inhibitory activity, hydroxyxanthones and hydroxythioxanthones showed no significant cytotoxicity for the tested cells.…”

Section: Resultsmentioning

confidence: 99%

Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents

Yılmaz

Guler

Barlas

et al. 2016

Macromol. Rapid Commun.

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Thioxanthone (TX) and its derivatives, which are widely used as photoinitiators in UV curing technology, hold promising research interest in biological applications. In particular, the use of TXs as anticancer agent has recently been manifested as an outstanding additional property of this class of molecules. Incorporation of TX molecules into specially designed polymers widens their practical use in such applications. In this study, two water-soluble, biocompatible, and stable polymers, namely poly(vinyl alcohol) and poly(ethylene glycol), possessing TX moieties at the side chains and chain ends, respectively, are prepared and used as anticancer and radiotherapy agents. The findings confirm that both polymers are potential candidates for therapeutic agents as they possess useful features including water-solubility, radiosensitizer effect, and anticancer activity in a polymeric scaffold.

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Section: Resultsmentioning

confidence: 99%

Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents

Yılmaz

Guler

Barlas

et al. 2016

Macromol. Rapid Commun.

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“…Unfortunately, increasing the loading of catalyst to 1 equivalent was ineffective for the present transformation, recovering the starting material 2c (Table 1, entry 5). Based on these results, we decided carry out a systematic screening of the reaction conditions by treating the model substrate 2c with various Lewis acid [26] in the presence of DCME in dichloromethane at room temperature ( Table 1). As shown in the Taking into account the results summarized in Table 1, we choose the Lewis acid SnCl2 for being the most efficient catalyst for the desired transformation.…”

Section: Resultsmentioning

confidence: 99%

<strong>Efficient synthesis and biological evaluation of dibenzo[b,e]oxepin-11(6H)-ones as potential anthelmintic agents</strong>

Gerbino

Scoccia

Castro

et al. 2016

Proceedings of the 20th International Electronic Conference on Synthetic Organic Chemistry

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The first systematic study for the construction of a small library dibenzo[b,e]oxepin-11(6H)-ones by direct intramolecular acylation from readily available 2-(phenoxymethyl)benzoic acids was developed. For this purpose, a novel and efficient cooperative system consisting of SnCl2 and Cl2CHOCH3 is presented. This methodology show be compatible with a wide variety of functional groups in good to excellent yields and high regioselectivity. The generality of new protocol was applied to the scalable and reproducible synthesis of tricyclic antidepressant doxepin. The synthesized dibenzo[b,e]oxepins were evaluated for their biological activities using free-living nematode Caenorhabditis elegans as effective and cost-efficient model system for anthelmintic discovery.

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“…As a result of our research programs involving the synthesis of new bioactive molecules [40][41][42][43][44][45][46][47] , we report herein for the first time synthesis of a new set of directly coupled quinolone-triazole conjugates. We also assessed biological activity profiles of these conjugates, with particular emphasis on their antioxidative properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of antibacterial and antioxidant activity of novel 2-phenyl-quinoline analogs derivatized at position 4 with aromatically substituted 4H-1,2,4-triazoles

Verbanac

Malik

Chand

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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C NMR, and finally mass spectrometry. All the synthesized compounds were evaluated in vitro for their potential antibacterial activity and their preliminary safety profile was assessed through cytotoxicity assay. Additionally, six selected conjugates were evaluated for their antioxidative properties on the basis of density functional theory calculations, using radical scavenging assay (DPPH) and cellular antioxidant assay. The reported results encourage further investigation of selected compounds and are shading light on their potential pharmacological use.

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An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization

Cited by 20 publications

References 49 publications

Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents

Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents

<strong>Efficient synthesis and biological evaluation of dibenzo[b,e]oxepin-11(6H)-ones as potential anthelmintic agents</strong>

Synthesis and evaluation of antibacterial and antioxidant activity of novel 2-phenyl-quinoline analogs derivatized at position 4 with aromatically substituted 4H-1,2,4-triazoles

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