Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents

Yılmaz, Görkem; Guler, Emine; Barlas, F. Baris; Timur, Suna; Yaǧcı, Yusuf

doi:10.1002/marc.201600189

Cited by 16 publications

(8 citation statements)

References 42 publications

(85 reference statements)

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“…Radiating the thioxanthone-polyethylene glycol material with 2.5 Gy exposure drastically decreased the A549 cell viability percentage to 30%. This research offers an option for the usage of low solubility xanthone and/or thioxanthone derivatives for in vivo and clinical uses [213]. In contrast to the reports on the clinical study of α-mangostin and DMXAA that are available now, the reports on both in vivo and clinical study of other xanthone derivatives are very limited.…”

Section: In Vivo and Clinical Anticancer Assays Of Xanthone Derivativesmentioning

confidence: 99%

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

et al. 2021

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The annual number of cancer deaths continues increasing every day; thus, it is urgent to search for and find active, selective, and efficient anticancer drugs as soon as possible. Among the available anticancer drugs, almost all of them contain heterocyclic moiety in their chemical structure. Xanthone is a heterocyclic compound with a dibenzo-γ-pyrone framework and well-known to have “privileged structures” for anticancer activities against several cancer cell lines. The wide anticancer activity of xanthones is produced by caspase activation, RNA binding, DNA cross-linking, as well as P-gp, kinase, aromatase, and topoisomerase inhibition. This anticancer activity depends on the type, number, and position of the attached functional groups in the xanthone skeleton. This review discusses the recent advances in the anticancer activity of xanthone derivatives, both from natural products isolation and synthesis methods, as the anticancer agent through in vitro, in vivo, and clinical assays.

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Section: In Vivo and Clinical Anticancer Assays Of Xanthone Derivativesmentioning

confidence: 99%

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

et al. 2021

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“…TX‐A was prepared according to a known procedure . Typically 1.0 g thiosalicylic acid (6.49 mmol, 1 eq) was added to 40 mL concentrated sulfuric acid and stirred for 10 min.…”

Section: Methodsmentioning

confidence: 99%

“…Different thiol, hydroxy, amine, aldehyde, and carboxylic acid derivatives of TX were reported in the past as effective one‐component photoinitiating systems and their initiation mechanism was elucidated. Recently, polymeric and polymerizable TX photoinitiators showed excellent performance in initiating polymerization reactions in the absence of co‐initiators, thus minimizing the risk of leaching . Furthermore, the absorption properties of TX could be shifted to the near UV and visible spectrum by incorporating polynuclear aromatic moieties such as anthracene, fluorene, and carbazole in the structure while keeping up the one‐component characteristics of the initiator .…”

Section: Introductionmentioning

confidence: 99%

One‐component, double‐chromophoric thioxanthone photoinitiators for free radical polymerization

Kreutzer

Yaǧcı

2017

J. Polym. Sci. Part A: Polym. Chem.

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Two one‐component, double‐chromophoric thioxanthone photoinitiators, namely TX‐EDA and TX‐DETA were synthesized by the reaction of thioxanthone aldehyde (TX‐A) with ethylenediamine (EDA) and diethylenetriamine (DETA), respectively via a facile Schiff base reaction. Both photoinitiators were characterized by spectral analysis and photobleaching studies. DFT calculations are employed to reveal the contribution of the different orbitals to the excitation of the initiators. The double‐chromophoric nature of the initiators gives rise to an increased absorption in the near UV region when compared with the pristine TX‐A. Photoinitiated polymerization of various vinyl monomers with TX‐EDA and TX‐DETA has been investigated in the presence and absence of a co‐initiator and compared for formulations consisting of precursor TX‐A. In addition, real‐time FTIR spectroscopic studies were performed in methyl methacrylate polymerization with both initiators. The higher efficiency observed with TX‐DETA may be attributed to the additional hydrogen donating sites adjacent to nitrogen atoms. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 3475–3482

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“…Remarkably, the utilization of PSAs for siRNA delivery to a desired area is of great importance in order to overcome a possible radiation resistance. 246 Among different PSAs, the chitosan-based nanocomposite is an outstanding one because this biopolymer can easily maintain its structural integrity before being exposed to the acidic media of cancerous cells.…”

Section: Polysaccharide Nanocomposites For Cancer Diagnosis and Treat...mentioning

confidence: 99%