Polysaccharide-based nanocomposites for biomedical applications: a critical review

Shokrani, Hanieh; Shokrani, Amirhossein; Sajadi, S. Mohammad; Yazdi, Mohsen Khodadadi; Seidi, Farzad; Jouyandeh, Maryam; Zarrintaj, Payam; Kar, Saptarshi; Kim, Seok‐Jhin; Kuang, Tairong; Rabiee, Navid; Hejna, Alexander; Saeb, Mohammad Reza; Ramakrishna, Seeram

doi:10.1039/d2nh00214k

Cited by 32 publications

(17 citation statements)

References 297 publications

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“…Furthermore, polysaccharide-based biomaterials have the potential to be used in skin tissue engineering because they can absorb a large amount of water. Due to their biocompatibility and good mechanical properties, they are also increasingly used for bone and cartilage tissue engineering and are also important for the tissue engineering of nerves [ 80 , 84 ].…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

“…Since they allow targeted delivery of incorporated drugs to target sites, preventing toxic effects on healthy cells, they can be loaded with a high concentration of drugs, allowing enhanced therapeutic effects due to sustained release. The loaded drug is successfully protected from metabolic processes and thus retains its bioactivity [ 3 , 84 ].…”

Section: Incorporation Of Different Therapeutic Substances Into Biopo...mentioning

confidence: 99%

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Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Kučuk

Primožič

Knez

et al. 2023

IJMS

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Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, biocompatibility, non-toxicity, and stability compared to various toxic metal nanoparticles, we decided to provide an overview on this topic. Therefore, the review focuses on the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems. A particular focus is on the encapsulation of many different therapeutic agents categorized as bioactive compounds, drugs, antibiotics, and other antimicrobial agents, extracts, and essential oils into protein- and polysaccharide-based nanocarriers. These show promising benefits for human health, especially for successful antimicrobial and anticancer activity. The review article, divided into protein-based and polysaccharide-based biopolymeric nanoparticles and further according to the origin of the biopolymer, enables the reader to select the appropriate biopolymeric nanoparticles more easily for the incorporation of the desired component. The latest research results from the last five years in the field of the successful production of biopolymeric nanoparticles loaded with various therapeutic agents for healthcare applications are included in this review.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Section: Incorporation Of Different Therapeutic Substances Into Biopo...mentioning

confidence: 99%

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Kučuk

Primožič

Knez

et al. 2023

IJMS

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“…Biopolymer (e.g., polysaccharide or protein) nanoparticles, [1][2][3] exhibiting great biodegradability, biocompatibility and bioavailability, have become one of the most practical nanometerscale platforms for biomedical applications ranging from drug delivery to tissue engineering. [4][5][6] In particular, polyelectrolyte biopolymers with repeating ionizable groups could confer their nanoparticles with unique physicochemical properties for modulating colloidal stability, surface interaction, permeability and cellular uptake. [7][8][9] Hence, the engineering of biopolymer-based nanoparticles has attracted considerable attention for developing advanced bio-applicable nanosystems, and some of these have realized clinical transitions.…”

Section: Introductionmentioning

confidence: 99%

Aqueous nanoprecipitation for programmable fabrication of versatile biopolymer nanoparticles

Ding

Gong

et al. 2023

Green Chem.

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“…Although polysaccharides are best known for appropriate biocompatibility and nontoxic nature, they suffer from poor mechanical properties. Therefore, there have been several kinds of research in which surface‐grafted 12 and crosslinked 13 polysaccharides have been employed for drug and gene delivery systems as well as electroconductive hydrogels 14–16 . Another limitation of polysaccharides could be difficulty of purification and extraction.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide‐based biomaterials in a journey from 3D to 4D printing

Shokrani

Seidi

et al. 2023

Bioengineering & Transla Med

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3D printing is a state-of-the-art technology for the fabrication of biomaterials with myriad applications in translational medicine. After stimuli-responsive properties were introduced to 3D printing (known as 4D printing), intelligent biomaterials with shape configuration time-dependent character have been developed. Polysaccharides are biodegradable polymers sensitive to several physical, chemical, and biological stimuli, suited for 3D and 4D printing. On the other hand, engineering of mechanical strength and printability of polysaccharide-based scaffolds along with their aneural, avascular, and poor metabolic characteristics need to be optimized varying printing parameters. Multiple disciplines such as biomedicine, chemistry, materials, and computer sciences should be integrated to achieve multipurpose printable biomaterials. In this work, 3D and 4D printing technologies are briefly compared, summarizing the literature on biomaterials engineering though printing techniques, and highlighting different challenges associated with 3D/4D printing, as well as the role of polysaccharides in the technological shift from 3D to 4D printing for translational medicine.

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Polysaccharide-based nanocomposites for biomedical applications: a critical review

Abstract: Polysaccharides (PSA) are taking specific position among biomaterials for advanced applications in medicine. Nevertheless, poor mechanical properties is known as the main drawback of PSA, which highlights need for PSA...

Cited by 32 publications

References 297 publications

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Aqueous nanoprecipitation for programmable fabrication of versatile biopolymer nanoparticles

Polysaccharide‐based biomaterials in a journey from 3D to 4D printing

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