Abstract:The first systematic study for the construction of a small library dibenzo[b,e]oxepin-11(6H)-ones by direct intramolecular acylation from readily available 2-(phenoxymethyl)benzoic acids was developed. For this purpose, a novel and efficient cooperative system consisting of SnCl2 and Cl2CHOCH3 is presented. This methodology show be compatible with a wide variety of functional groups in good to excellent yields and high regioselectivity. The generality of new protocol was applied to the scalable and reproducibl… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.