An Appraisal of the Efficacy and Effectiveness of Nanoscaffolds Developed by Different Techniques for Bone Tissue Engineering Applications: Electrospinning A Paradigm Shift

Sakina, Rabeil; Ali, Murtaza Najabat

doi:10.1002/adv.21429

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…In recent years electrospinning technology has attracted increasing interest for applications in the field of bone regeneration [1][2][3]. This scaffold fabrication technique is cheap and scalable; moreover it offers the possibility to process a great variety of polymers, both synthetic and natural, into continuous fibers having micro-to nanometric diameters with controlled surface texture and orientation.…”

Section: Introductionmentioning

confidence: 99%

Fast Coprecipitation of Calcium Phosphate Nanoparticles inside Gelatin Nanofibers by Tricoaxial Electrospinning

Panzavolta

Gualandi

Fiorani

et al. 2016

Journal of Nanomaterials

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We present an effective method for fabricating electrospun gelatin nanofibers containing well-dispersed inorganic nanoparticles. The new method encompasses the use of a special triaxial needle where mixing calcium and phosphate aqueous solutions in an intermediate needle yield calcium phosphate (CaP) nanoparticles that immediately after precipitation are dragged by the outer polymeric solution and incorporated directly in the electrospinning jet, before nanofiber formation. Gelatin electrospun mats containing different amounts of CaP nanoparticles were prepared and characterized by SEM, TEM, TGA, and stress-strain measurements. The results demonstrate that CaP particles having diameter of few tens of nanometers were successfully introduced in the gelatin nanofibers during the electrospinning process and that they were well dispersed throughout the fiber length. In addition, the use of the special triaxial needle enabled modulating the CaP amount in the nanofibers.

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Section: Introductionmentioning

confidence: 99%

Fast Coprecipitation of Calcium Phosphate Nanoparticles inside Gelatin Nanofibers by Tricoaxial Electrospinning

Panzavolta

Gualandi

Fiorani

et al. 2016

Journal of Nanomaterials

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“…Biomimetic bone graft also requires specialized properties such as higher mechanical strength and stiffness to overcome the force exerted on the most acknowledged load bearing tissue. 3 Additionally, the tissue engineered bone grafts should satisfy several properties such as biocompatibility, biodegradability, and suitable surface chemistry to mimic the structure of the bone, thus regulating the cell attachment, osseointegration, and bone tissue formation within a short period of time. 4,5…”

Section: Introductionmentioning

confidence: 99%

Poly-3-hydroxybutyrate-co-3-hydroxyvalerate containing scaffolds and their integration with osteoblasts as a model for bone tissue engineering

et al. 2015

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Nano/micro engineered polymeric materials offer expansive scope of biomimetic scaffolds for bone tissue engineering especially those involving electrospun biodegradable nanofibers incorporated with inorganic nanoparticles, thus mimicking the extracellular matrix of bone both structurally and chemically. For the first time, poly-3-hydroxybutyrate-co-3-hydroxyvalerate containing natural poly-(α, β)-DL-aspartic acid and inorganic hydroxyapatite nanofibers were fabricated using poly-3-hydroxybutyrate-co-3-hydroxyvalerate: poly-(α, β)-DL-aspartic acid at a ratio of 80:20 (w/w) added with 1% (w/v) of hydroxyapatite, by the process of electrospinning. The surface morphology, chemical, and mechanical properties of electrospun poly-3-hydroxybutyrate-co-3-hydroxyvalerate, poly-3-hydroxybutyrate-co-3-hydroxyvalerate/poly-(α, β)-DL-aspartic acid, and poly-3-hydroxybutyrate-co-3-hydroxyvalerate/poly-(α, β)-DL-aspartic acid/hydroxyapatite nanofibers were characterized by using field emission scanning electron microscope, Fourier transform infrared spectroscopy, and tensile tester, respectively. Human fetal osteoblasts were cultured on different nanofibrous scaffolds for evaluating the cell proliferation, alkaline phosphatase activity, and mineralization. Cells on poly-3-hydroxybutyrate-co-3-hydroxyvalerate/poly-(α, β)-DL-aspartic acid/hydroxyapatite scaffolds demonstrated higher proliferation (30.10%) and mineral deposition (37.60%) than the cells grown on pure poly-3-hydroxybutyrate-co-3-hydroxyvalerate scaffolds. Obtained results highlight the synergistic effect of poly-3-hydroxybutyrate-co-3-hydroxyvalerate, poly-(α, β)-DL-aspartic acid, and hydroxyapatite towards the enhancement of the osteoinductivity and osteoconductivity of human fetal osteoblasts, demonstrating the appropriate physicochemical and biological properties of poly-3-hydroxybutyrate-co-3-hydroxyvalerate/poly-(α, β)-DL-aspartic acid/hydroxyapatite nanofibers to function as a substrate for bone tissue regeneration.

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Tough and hierarchical porous cryogel scaffolds preparation using n-butanol as a non-solvent

Sen

Özçelık

Ozmen

2018

International Journal of Polymeric Materials and Polymeric Biom

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An Appraisal of the Efficacy and Effectiveness of Nanoscaffolds Developed by Different Techniques for Bone Tissue Engineering Applications: Electrospinning A Paradigm Shift

Cited by 3 publications

References 78 publications

Fast Coprecipitation of Calcium Phosphate Nanoparticles inside Gelatin Nanofibers by Tricoaxial Electrospinning

Fast Coprecipitation of Calcium Phosphate Nanoparticles inside Gelatin Nanofibers by Tricoaxial Electrospinning

Poly-3-hydroxybutyrate-co-3-hydroxyvalerate containing scaffolds and their integration with osteoblasts as a model for bone tissue engineering

Tough and hierarchical porous cryogel scaffolds preparation using n-butanol as a non-solvent

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