Fast Coprecipitation of Calcium Phosphate Nanoparticles inside Gelatin Nanofibers by Tricoaxial Electrospinning

Abstract

We present an effective method for fabricating electrospun gelatin nanofibers containing well-dispersed inorganic nanoparticles. The new method encompasses the use of a special triaxial needle where mixing calcium and phosphate aqueous solutions in an intermediate needle yield calcium phosphate (CaP) nanoparticles that immediately after precipitation are dragged by the outer polymeric solution and incorporated directly in the electrospinning jet, before nanofiber formation. Gelatin electrospun mats containing different amounts of CaP nanoparticles were prepared and characterized by SEM, TEM, TGA, and stress-strain measurements. The results demonstrate that CaP particles having diameter of few tens of nanometers were successfully introduced in the gelatin nanofibers during the electrospinning process and that they were well dispersed throughout the fiber length. In addition, the use of the special triaxial needle enabled modulating the CaP amount in the nanofibers.

Enhancement of the mechanical properties and thermostability of poly(vinyl alcohol) nanofibers by the incorporation of sodium chloride

“…Kinds of nanoparticles were incorporated into the nanofibers in the electrospinning process, and particles distributed and dispersed along the as‐prepared nanofiber with diameters of few tens of nanometers . In this article, when the jet of the electrospun solution travelled to the receiver, the solvent (H 2 O) evaporated accomplishing with the crystallization of NaCl.…”

Blend electrospinning, coaxial electrospinning, and emulsion electrospinning techniques

“…However, setting of chemical and physical conditions is even more problematic in this methods [ 102 104]. Triaxial electrospinning was successfully used for delivery of doxycycline [102], nisin [105], and calcium phosphate nanoparticles [106]. This technology allows multiphasic delivery of active molecules with complex release profiles [107,108].…”

“…This technology allows multiphasic delivery of active molecules with complex release profiles [107,108]. Moreover, the technology is useful for in situ synthesis of nanoparticles, i.e., by coprecipitation for calcium phosphate nanoparticles [106].…”

Random lasing from structurally-modulated silk fibroin nanofibers

“…Integration of such device in biological tissues and measurement of its lasing features based on the observed interconnects with structural and mechanical properties may allow non-contact measurement of the structural modifications of the scaffolds in the host systems. SF nanofibers have been structured to form composites with controlled mechanical strengths by incorporating various nanoparticles 52 , 53 . For instances, hydroxyapatite 54 , 55 and chitosan 56 , 57 nanoparticles have been employed to tune the mechanical properties of the SF-based composites.…”