Ameliorative Potentials of Cocoyam (Colocasia esculentaL.) and Unripe Plantain (Musa paradisiacaL.) on the Relative Tissue Weights of Streptozotocin-Induced Diabetic Rats

Abstract

Aim. To investigate the ameliorating potentials of cocoyam (Colocasia esculenta L.) and unripe plantain (Musa paradisiaca L.) incorporated feeds on the renal and liver growths of diabetic rats, induced with 55 and 65 mg/kg body weight of Streptozotocin. Method. The blood glucose level of the rats was measured with a glucometer, the protein and glucose and specific gravity (SPGR) in the urine samples of the rats were measured using urine assay strips and urinometer respectively. The chemical composition and antioxidant screening of the test feeds were carried out using standard techniques. Results. Administration of the test feeds for 21 days to the diabetic rats of groups 4 and 5, resulted in 58.75% and 38.13% decreases in hyperglycemia and amelioration of their elevated urinary protein, glucose, SPGR, and relative kidney weights. The diabetic rats administered cocoyam incorporated feeds, had 2.71% and 19.52% increases in weight and growth rates, the diabetic rats administered unripe plantain incorporated feeds had 5.12% and 29.52% decreases in weight and growth rates while the diabetic control rats had 28.69%, 29.46%, 248.9% and 250.14% decreases in weights and growth rates. The cocoyam incorporated feeds contained higher antioxidants, minerals and phytochemicals except alkaloids than unripe plantain feed. Conclusion. Cocoyam and unripe plantain could be useful in the management of diabetic nephropathy.

Dietary intake of boiled breadfruit (Treculia africana) seeds did not improve hyperglycemia in streptozotocin induced diabetic rats: Effect on the oral glucose tolerance of normoglycemic rats

“…Diabetic renal hypertrophy constitutes an early development in the progression of glomerular pathology, which occurs in the absence of mesangial expansion (Eleazu et al, 2013a). Therefore, the increased kidney weights of the diabetic control suggest renal hypertrophy for this group of rats.…”

“…When someone suffers from diabetes, the liver has been found to increase in weight due to increased lipolysis, resulting from insulin absence or insensitivity, while the kidney has been reported to increase in weight due to glucose overutilization and the subsequent enhancement of glycogen synthesis, lipogenesis, and protein synthesis. These changes could lead to complications in renal and hepatic functions (Eleazu et al, 2013a). Many specific interventions have been carried out in the management and prevention of diabetes and one of the integral components is medical nutrition.…”

Análisis de Nutrientes de la Raíz de la Malanga (Colocasia esculenta Schott) en el Trópico Seco de Colombia

“…El contenido de fibra bruta (4.882 %+0.020), forma parte integral de los carbohidratos y se puede encontrar distribuida en el tejido vegetal, dependiendo en muchos casos, del grado de maduración (Barrera et al, 2004), es por esto que se requiere identificar el periodo de cosecha de la malanga. Estos resultados son superiores a los encontrados por Eleazu et al, 2013, quienes encontraron elevadas cantidades de fibra cruda en la harina de la malanga. El contenido de grasa (0.530 %+0.002) es bajo en las raíces, aunque se han encontrado contenidos de 1.75 %, en otras raíces y tubérculos andinos (Barrera et al, 2004).…”

Effect of cocoyam (Colocasia esculenta), unripe plantain (Musa paradisiaca) or their combination on glycated hemoglobin, lipogenic enzymes, and lipid metabolism of streptozotocin-induced diabetic rats

“…(Mwenye et al, 2010). The antidiabetic action of cocoyam in streptozotocin diabetic rat models has also been reported (Eleazu et al, 2013).…”