Effect of cocoyam (<i>Colocasia esculenta</i>), unripe plantain (<i>Musa paradisiaca</i>) or their combination on glycated hemoglobin, lipogenic enzymes, and lipid metabolism of streptozotocin-induced diabetic rats

Eleazu, Chinedum; Eleazu, Kate; Iroaganachi, M

doi:10.3109/13880209.2015.1016181

Cited by 16 publications

(14 citation statements)

References 26 publications

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“…The presence of this compound in C. esculenta suggests it could possess these properties, and further re-affirms its hypocholesterolemic properties as previously reported (Eleazu et al 2016); it also suggests the antioxidant potentials of C. esculenta.…”

Section: Discussionsupporting

confidence: 64%

“…suggests that it may possess anti-inflammatory, anemiagenic, antialopecic, anti-leucotriene-D4, immunostimulatory properties and also provides a biochemical rationale for the inhibition of breast and prostate cancer cell lines demonstrated by C. esculenta as reported by Kundu et al (2012) and for the hypocholesterolemic actions also demonstrated by C. esculenta as reported by Eleazu et al (2016). 9,12-Octadecadienoyl chloride, a linoleoyl chloride that constituted 0.77% of the extract was reported to possess antisecretory, choleretic, contraceptive, antispermatogenic and antitubercular properties (Kalaivani et al 2012).…”

Section: Discussionmentioning

confidence: 99%

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Characterization of the natural products in cocoyam (Colocasia esculenta) using GC–MS

Eleazu

2016

Pharmaceutical Biology

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Context: There is paucity of information in literature on the natural products in cocoyam [Colocasia esculenta Linn (Araceae)] that confer it with biological properties. Objectives: This study investigated the antioxidant properties of C. esculenta and also reported for the first time the natural products in C. esculenta that justify its biological properties. Materials and methods: The antioxidant activity of the methanol extract (50-250 lg/mL) of C. esculenta was determined using the 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical and reducing power assays. Characterization of the natural products in C. esculenta was done using the gas chromatographic-mass spectrometric (GC-MS) technique. The experiment lasted for 3 months. Results: GC-MS analysis of methanol/chloroform extract of the flour of C. esculenta indicated the presence of eight compounds, namely hexadecanoic acid methyl ester (0.43%), octadecanoic acid (20.91%), 9,12-octadecadienoyl chloride (0.77%), 11-octadecenoic acid methyl ester (2.12%), 9-octadecenoic acid (64.37%), 3-hexadecyloxycarbonyl-5-(2-hydroxylethyl)-4-methylimidazolium(1.36%), hexanedioic acid, bis(2-ethylhexyl)ester (1.36%) and 3,5-di-t-butyl phenol (3.27%). The total phenolic content of C. esculenta was 15.15 ± 0.35 mg Gallic Acid Equivalence/g and it was significantly higher (p < 0.05) than the total flavonoid (8.50 ± 0.42 mg Quercetin Equivalence/g) and condensed tannin (4.40 ± 0.14 mg Catechin Equivalence/g) contents, respectively. C. esculenta possessed strong antioxidant capacity though it was lower than that of standard quercetin. Discussion and conclusion: Results showed that C. esculenta possesses strong antioxidant activity and also contains some important bioactive compounds that justify its medicinal properties as used in ethnomedicine. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Characterization of the natural products in cocoyam (Colocasia esculenta) using GC–MS

Eleazu

2016

Pharmaceutical Biology

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“…exerts direct toxicity on β -cells resulting in necrosis within 48 hrs and causes permanent hyperglycemia. This causes the generation of superoxide, hydrogen peroxide, nitric oxide, and hydroxyl radicals which are responsible for β -cell damage and necrosis resulting in hyperglycemia [ 27 – 29 ].…”

Section: Discussionmentioning

confidence: 99%

Gmelina arboreaRoxb. (Family: Verbenaceae) Extract Upregulates theβ-Cell Regeneration in STZ Induced Diabetic Rats

Attanayake

Jayatilaka

Pathirana

et al. 2016

Journal of Diabetes Research

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Gmelina arborea Roxb. (common name: Et-demata, Family: Verbenaceae) has been used traditionally in Sri Lanka as a remedy against diabetes mellitus. The objective of the present study was to evaluate antidiabetic mechanisms of the aqueous bark extract of G. arborea in streptozotocin induced (STZ) diabetic male Wistar rats. Aqueous bark extract of G. arborea (1.00 g/kg) and glibenclamide as the standard drug (0.50 mg/kg) were administered orally using a gavage to STZ diabetic rats (65 mg/kg, ip) for 30 days. The antidiabetic mechanisms of aqueous extract of G. arborea (1.00 g/kg) were determined at the end of the experiment. The fasting blood glucose concentration was significantly lowered and the serum insulin and C-peptide concentrations were increased by 57% and 39% in plant extract treated rats on day 30, respectively (p < 0.05). The histopathology and immunohistochemistry results of the plant extract treated group showed a regenerative effect on β-cells of the pancreas in diabetic rats. In addition, serum lipid parameters were improved in G. arborea extract treated diabetic rats. The results revealed that the aqueous stem bark extract of G. arborea (1.00 g/kg) showed beneficial effects against diabetes mellitus through upregulating the β-cell regeneration and biosynthesis of insulin in diabetic rats.

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“…The adaptogenic effect of ginsengs roots, for example, is associated with the presence of saponins (Metwaly et al 2019;Shi et al 2019), while for mushrooms and seaweed, the effects are associated to saccharides (Ling et al 2017;Mallard et al 2019). Saponins and some types of polysaccharides, as starch, are very common in roots, and the effects observed for C. esculenta were correlated to the presence of saponins (Azubuike et al 2018;Eleazu et al 2016;. Other less known edible roots, but also cited along the centuries, are Plumbago scandens L. (Plumbaginaceae), Spondias venulosa (Engl.)…”

Section: Species Cited By Other Authorsmentioning

confidence: 99%

Bioactive Potential of Brazilian Plants Used as Food with Emphasis on Leaves and Roots

Mügge

Prates

Paula-Souza

et al. 2021

Local Food Plants of Brazil

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Effect of cocoyam (Colocasia esculenta), unripe plantain (Musa paradisiaca) or their combination on glycated hemoglobin, lipogenic enzymes, and lipid metabolism of streptozotocin-induced diabetic rats

Cited by 16 publications

References 26 publications

Characterization of the natural products in cocoyam (Colocasia esculenta) using GC–MS

Characterization of the natural products in cocoyam (Colocasia esculenta) using GC–MS

Gmelina arboreaRoxb. (Family: Verbenaceae) Extract Upregulates theβ-Cell Regeneration in STZ Induced Diabetic Rats

Bioactive Potential of Brazilian Plants Used as Food with Emphasis on Leaves and Roots

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