Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats

Hamza, Alaaeldin Ahmed

doi:10.1016/j.fct.2009.10.022

Cited by 152 publications

(95 citation statements)

References 26 publications

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“…Previously, [121] showed that oral administration of hydroalcoholic extract of M. oleifera fresh pods increased hepatic levels of cytochrome b 5 , cytochrome P 450 , glutathione peroxidase, catalase, reductase and S-transferase enzymes involved in reactions of Phases I and II responsible by detoxification of exogenous substances such as carcinogens and plant poisonous. These findings were corroborated by [122], who showed that seed hydroethanolic extract (1g/kg) avoided the development of hepatic fibrosis induced by carbon tetrachloride and reduced histopathological and biochemical characters of inflammatory necrosis on hepatocytes (cellular infiltration, fatty degeneration and levels of AST, ALT, myeloperoxidase, collagens and biomarkers of oxidative stress). These findings highlighted the chemopreventive properties that have been attributed to antioxidant compounds in the seeds [68,72,121].…”

Section: Seedssupporting

confidence: 68%

Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

Ferreira¹,

Araújo²,

Freitas³

et al. 2014

Pharmacology and Therapeutics

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Section: Seedssupporting

confidence: 68%

Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

Ferreira¹,

Araújo²,

Freitas³

et al. 2014

Pharmacology and Therapeutics

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“…Effects of PAE on the pathologic grading of immunological liver fibrosis rats induced by porcine serum (mean ± SD; n=8). products (22,23). An effective therapeutic approach against the development of hepatic fibrosis is still needed.…”

Section: Discussionmentioning

confidence: 99%

A standardized extract from Paeonia lactiflora and Astragalus membranaceus attenuates liver fibrosis induced by porcine serum in rats

Sun

Wang²,

Líu³

et al. 2011

Int J Mol Med

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Abstract. Paeonia lactiflora and Astragalus membranaceus are two popular traditional Chinese medicines, commonly used in Chinese herb prescription to treat liver disease. The extract prepared from the roots of Paeonia lactiflora and Astragalus membranaceus (PAE) demonstrated better hepatoprotective activity than the herbs used individually as shown in our previous studies. This study was carried out to investigate the effects of PAE on liver fibrosis induced by porcine serum (PS) in rats and to explore its possible mechanisms. Liver fibrosis was induced in male Wistar rats by injection with PS intraperitoneally. The rats were randomly divided into a normal control group, a liver fibrosis model group and a PAE (40, 80, 160 mg•kg -1 ) treated group. After a 16-week treatment, PAE-treated rats showed significantly reduced liver damage and symptoms of liver fibrosis upon pathological examination. Administration of PAE significantly decreased serum HA, PC III levels, and content of hydroxyproline in the liver tissue of fibrotic rats. It also restored the decrease in SOD and GSH-Px activities and inhibited the formation of lipid peroxidative products during PS treatment. In vitro, PAE also significantly decreased [ 3 H]-thymidine incorporation in hepatic stellate cells (HSCs) stimulated with platelet-derived growth factor-B subunit homodimer (PDGF-BB). Moreover, PAE significantly decreased the expression of PDGF receptor beta (PDGFR-β) and p-ERK1/2, p-p38, p-JNK. The results showed that PAE displays antifibrotic effects in rats induced by PS, the mechanism by which might be associated with its ability to scavenge free radicals, decreasing the expression of PDGFR-β, inhibition of HSC proliferation and MAPK activation. These findings indicate that PAE is a potential agent for the prevention of liver fibrosis.

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“…None of these studies reported effects involving the important excretory products of metabolism urea and creatinine. Sharinfudin et al (12) did not report any reasonable change in the waste products after acetaminophen intoxication at 7g/kg body weight and still did not report on studies of 200mg and 400mg extract per kg body weight thus, limiting comparability. In the study being reported by this article, prior administration of aqueous leaf extract of Moringa oleifera reduced the acetaminophen-induced excretion of urea and creatinine, two excretory indices of biochemical evaluation of kidney and renal functions.…”

Section: IVmentioning

confidence: 99%

“…The report of Fakurazi et al (11) indicated that Moringa oleifera exhibited cytoprotection in acetaminophen-induced rats and via restoration of glutathione levels. Hamza (12) reported protection against liver fibrosis while Sharifudin et al (13) reported that Moringa extracts exhibited protection against acetaminophen-induced hepatotoxicity. None of the above work reported an effect on kidney functions, kidney toxicity or excretory products like urea and creatinine which are reliable estimable biomolecules of evaluation of kidney damage.…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Moringa Oleifera Lam Aqueous Leaf Extract on Some Excretory Products and Hematological Parameters in Acetaminophen Induced Albino Rats

.¹,

Daja²,

Gadaka³

et al. 2014

IOSRJNHS

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Background: Aqueous leaf extract of Moringa oleifera (MO) was evaluated for its ability to ameliorateacetaminophen-induced toxicity in albino rats using serum urea and creatinine levels as well as heamatological parameters as indices of evaluation. Methods: Groups of five Albino rats were pre-administered with MO (200 and 400mg/kg/bw) prior to a single dose administration of acetaminophen (3g/kg body weight). Haematological and biochemical indices were determined using standard methods. Results: Pretreatment of 200mg and 400 mg/kg body weight prior to acetaminophen administration caused significant reductions(p<0.05) in the test groups when compared to normal control groups in the levels of urea and creatinine in serum. There were no significant difference in the haematological parameters between the test and control groups. Conclusion: Results suggest that aqueous extract of Moringa oleifera administration would affect biologicalresponse to acetaminophen in kidney functions.

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Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats

Cited by 152 publications

References 26 publications

Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

A standardized extract from Paeonia lactiflora and Astragalus membranaceus attenuates liver fibrosis induced by porcine serum in rats

Protective Role of Moringa Oleifera Lam Aqueous Leaf Extract on Some Excretory Products and Hematological Parameters in Acetaminophen Induced Albino Rats

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