Ameliorative Effect of Moringa oleifera Extract on Male Fertility in Paroxetine Treated Rats

Abstract

Paroxetine is one of the selective serotonin reuptake inhibitor that is used for treating major depressive disorders but it has many side effects. Therefore, this study was planned to evaluate the possible protective effect of Moringa oleifera extract on the fertility of male rats treated with paroxetine. A total of forty adult male albino rats were equally allocated into four groups, each of 10 rats: Rats received 0.5 mL distilled water, 400 mg/kg BW of moringa hydroalcoholic extract, 10 mg/ kg BW of paroxetine, for groups 1, 2 and 3, respectively. While, rats of group 4 received moringa hydroalcoholic extract and paroxetine simultaneously at the same previously mentioned doses. All treatments were administered orally once daily for 60 successive days. Paroxetine treated group showed a significant decrease in the serum levels of Follicle stimulating hormone (FSH), Luteinizing hormone (LH), testosterone, estrogen and testicular catalase, glutathione (GSH), glutathione peroxidase (GPX), sperm count and sperm motility. Moreover, paroxetine evoked a significant increase in sperm abnormalities, testicular DNA fragments and testicular malondialdehyde (MDA) level compared with the control group. However, the concurrent administration of moringa extract with paroxetine was ameliorating the aforementioned alterations compared with paroxetine treated group. It could be concluded that, Moringa oleifera extract alleviated reprotoxicity induced by paroxetine in male rats.

Moringa Oleifera Leaves Extract Ameliorates Melamine-induced Testicular Toxicity in Rats

“…However, it was found otherwise in M/MOLE group compared to melamine treated group. These results are in agreement with those reported previously (El-Sheikh et al, 2016), who revealed an increase in the level of serum testosterone, LH and FSH in male Wister rats after administration of moringa.…”

Effects of paroxetine on biochemical parameters and reproductive function in male rats

“…Hence, the obtained results in this work revealed that paroxetine altered the semen pro ile by a decrease in sperm count, spermatids number, sperm viability and motility whereas, sperm abnormalities are increased. In agreement with our ind-ings, (El-Sheikh et al, 2016) showed that paroxetine administration to male rats at a dose of 3.6mg/kg (for 20,30 days) and 10mg/kg (for 60 days) respectively could cause a reduction in the level of FSH, LH and testosterone accompanied by signi icant decreases in sperm count, motility, viability and function with an increase in sperm abnormalities.…”

Ameliorative Effect of Aqueous Leaf Extract of Moringa oleifera on Reproductive Function Following Cadmium Chloride Induced Oxidative Stress in Male Wistar Rats

“…The results indicate that malondialdehyde levels of groups 2 and 5 rats were significantly higher than group 1 rats, suggesting an alteration in antioxidant levels in rats treated with cadmium chloride. This is similar to the report by El-Sheikh et al (2016) in which malondialdehyde levels was significantly increased in rats treated with paroxetine to induce toxicity. The present results further show a significant decrease in malondialdehyde levels of groups 3 and 4 rats in comparison to group 2 rats, indicating a possible protective capacity of the leaf extract of M. oleifera.…”

“…In the present report, no significant changes were noted in other sperm parameters except for an increase in the percentage of sperm viability and the percentage of normal spermatocytes seen amongst group 4 rats. Results obtained from histological analysis essentially confirmed the histological basis for the ameliorative effect of M. oleifera leaf extract on reproductive function in male Wistar rats and corroborates with the report of El-Sheikh et al (2016).…”