Moringa Oleifera Leaves Extract Ameliorates Melamine-induced Testicular Toxicity in Rats

Abstract

Many factors such as cryptorchidism, testicular torsion, varicocele, hyperthyroidism, infection, physical exertion, hormonal imbalance, the impact of xenobiotics induce the formation of reactive oxygen species (ROS) in the testis (Aitken and Roman, 2008). ROS is one of the principal causes of alteration in glucose homeostasis in testis, especially in terms of lactate production and modulation of LDH activity (Rossi et al., 2016) and apoptosis of germ cell (Rao and Shaha, 2000).Moringa oleifera (MO), a drumstick or horse-radish tree from Africa and India, possess high nutritional and research Article Abstract | Testicular toxicity is a significant cause of male infertility. It may occur due to hormonal, nutritional, behavioral, and environmental imbalance. Moringa oleifera, on the other hand, is known to have antioxidant, antiinflammatory, anti-tumor, anti-hypertensive, anti-diabetic properties. This study assessed the ameliorative effect of Moringa oleifera leaves extract (M/MOLE) on melamine-induced testicular toxicity in rats. Fifty Sprague Dawley (8weeks old) male rats were randomly assigned to group 1 (control), group 2 ( Moringa oleifera leaves extract only), group 3 (administered melamine only), and group 4 (both melamine and M/MOLE). Melamine significantly decreased (P < 0.05) semen quality, testicular weight, gonadal-somatic index, follicle-stimulating hormone (FSH), free testosterone, total testosterone, and an expression of steroidogenic enzyme genes (CYP11A1 and HSD17B3). A concurrent administration of M/MOLE reversed the clinical impact of Melamine treatment (P < 0.05). Histopathological examination revealed an improvement in testicular tissue injury in concurrent M/MOLE treatment groups than the melamine group. In conclusion, MOLE was effective in improving the toxic effects of melamine on testicular tissue in rats.

Moringa oleifera ethanolic extract ameliorates the testicular dysfunction resulted from HFD‐induced obesity rat model

“…Administration of MOLE in obesity-induced groups improved these parameters to similar levels as the control and MOLE groups. Our findings agree with previous studies, which reported that the administration of MOLE ameliorates tramadol-induced (Abd et al, 2020) or melamine-induced (Mansour et al, 2020) testicular injuries by abolishing oxidative stress and improving the seminal parameters in male rats.…”

Novel Sono-synthesized Triazole Derivatives Conjugated with Selenium Nanoparticles for cancer treatment

“…It acts as an aldehyde to form SeNPs and stabilize the nanostructure of the formed nanoparticles. Meanwhile, the glucosinolates have been oxidized to gluconic acid [47,[62][63][64]. The reduction of Selenium cation can be made by some organic compounds.…”

“…The importance of selenium nanoparticles (SeNPs) comes from their low toxicity and bioavailability. Moreover, they are biocompatible and can interact with proteins [47,48]. SeNPs are known as potent anticancer agents at high dosages [49].…”

Finishing of cellulosic fabrics based on SeNPs@triazole derivatives as anti- mosquito

“…Selenium (Se) is an essential trace element that is crucial for many cellular functions by the incorporation of selenoproteins (Skalickova et al, 2017). The importance of Selenium nanoparticles (SeNPs) come from its low toxicity, bioavailability, its interaction with proteins and biocompatible when compared to organic and inorganic selenium (Mansour et al, 2020;Ramamurthy et al, 2013). The selenium nanoparticles are known for its potent anticancer activity at high dosage (Fernandes and Gandin, 2015).…”