Ameliorative effect of curcumin on lead‐induced hematological and hepatorenal toxicity in a rat model

Abstract

Introduction Lead (Pb) is a ubiquitous toxic heavy metal that inflicts numerous clinical consequences on humans. Curcumin is the principal component of turmeric, which is reported to have antioxidative properties. This study aimed at evaluating the ameliorative effects of curcumin on Pb‐induced hepatorenal toxicity in a rat model. Methods Thirty‐six male Sprague‐Dawley rats were randomly assigned into five groups with 12 rats in the control (normal saline) and six rats each for the lead‐treated group (LTG) (50 mg/kg lead acetate [Pb acetate] for 4 weeks), recovery group (50 mg/kg Pb acetate for 4 weeks and left with no treatment for another 4 weeks), treatment group 1 (Cur100) (50 mg/kg Pb acetate for 4 weeks, followed by 100 mg/kg curcumin for 4 weeks), and treatment group 2 (Cur200) (50 mg/kg Pb acetate for 4 weeks, followed by 200 mg/kg curcumin for 4 weeks). All the experimental groups received oral treatments via orogastric‐tube on alternate days. Pb concentration in the liver and kidney of the rats were evaluated using inductive‐coupled plasma mass spectrometry techniques. Results Pb‐administered rats revealed significant alteration in oxidative status and increased Pb concentration in their liver and kidney with obvious reduction of hemogram and increased in leukogram as well as aberration in histological architecture of the liver and kidney. However, treatment with curcumin reduces the tissue Pb concentrations and ameliorates the above mention alterations. Conclusions The results in this study suggested that curcumin attenuates Pb‐induced hepatorenal toxicity via chelating activity and inhibition of oxidative stress.

Title: Effect of Curcumin and Ginger on Adverse Effects of Levofloxacin in Male Rats

“…Also, administration of LFX (40 mg/kg BW.) daily for two weeks showed a reduction in catalase, SOD and GSH as well as rise in MDA levels in liver tissue of rats [44] 49,59]. Our results and interpretations are in agreement with aforementioned reports [14, 46, 50,].…”

“…Co-supplementation of vitamin E, curcumin or ginger with LFX ameliorates the abovementioned aberrations caused by LFX toxicity; this supports the hepatorenal protective, antioxidant, and antiinflammatory properties of vitamin E, curcumin or ginger on the liver and kidney parameters [48,[55][56][57][58]. [56][57][58][59][60][61]. These results contribute antioxidant activity of vitamin E, curcumin or ginger, which inhibits the generation of free radicals in the body, neutralizes and scavenges them, and chelates prooxidant transition metals such as iron [14,20,45,62,63].…”

“…Furthermore, ginger may protect against cisplatin-induced hepatorenal damage, since there was a substantial improvement in liver and kidney functions with lower ALT, AST, ALP, urea, and creatinine levels when compared to the cisplatin group [65]. Administration of Z. officinale (250 and 500 mg/kg, per Os) with or without vitamin E ameliorated nephrotoxicity produced by cisplatin in mice [59].…”

A Review of the Role of Curcumin in Metal Induced Toxicity

“…Furthermore, in rat experiments with Pb accumulation in the liver and kidneys, it was shown that CUR is an effective inducer of the post-accumulation effects of oxidative toxicity. The results have shown a decrease in the Pb amount in the affected organs and the relief of degenerative changes caused by Pb [156].…”

Hematological and biochemical investigations on the effect of curcumin and Thymoquinone in male mice exposed to Thioacetamide

“…The results revealed that CUR inhibited hepatic fibrosis and liver fibrogenesis with regulation of the immune system mechanism against CCl 4 toxicity. Abubakar et al (2020) evaluated the ameliorative effects of CUR on lead (Pb)-induced hepatorenal toxicity in rats. The results showed that CUR attenuates Pb-induced hepatorenal toxicity via chelating activity and inhibition of oxidative stress.…”