Abstract:The capacity of a commercially available pool of bovine bone morphogenetic proteins (BMPs) to stimulate osteogenesis in the rat alveolar healing was investigated by histometric analysis. Male rats were anesthetized and had their upper incisor extracted. A pool of purified bovine BMPs adsorbed to microgranular resorbable hydroxyapatite was agglutinated with bovine collagen and saline before implantation into the alveolar socket. The implanted and control rats (n=30 per group) were sacrificed 1 to 9 weeks postop… Show more
“…Osteocalcin and osteopontin expression marks the late stage of osteoblast differentiation, and BMP-2 is an important factor for osteoblast maturation and osteoblast activity. 2,3,15 In our study, the expressions of BMP-2 in 21 days observation after using chitosan gel with high molecular weight was decreasing. Probably, the activity of ALP has decreased.…”
Section: Discussionmentioning
confidence: 49%
“…The major proportion of bone formation and the maximum mineral density has occurred in the end of the 2 nd week. In the end of the 2 nd week the activity of ALP has decreased 2 The using of chitosan gel with high molecular weight could increasing the expression of BMP-2. BMP-2 is major growth factor in bone healing.…”
Section: Discussionmentioning
confidence: 99%
“…The BMP s , released during osteoclastic bone resorption, are capable of inducing differentiation of mesenchymal cells into osteoblasts (osteinduction), stimulating bone formation in both remodeling and repairing process. 1,2 Chitosan is carbohydrate copolymer composed of glucosamine and N-acetyl-D-glucosamine units. Chitosan has a number of properties including biocompatibility, biodegradability, mucoadhesiveness and wound healing capabilities that make it useful as a biomaterial.…”
Section: Introductionmentioning
confidence: 99%
“…3 Chitosan is very versatile and can be prepared as films, gels, sponges and other forms and has been used in various applications including wound healing and bone tissue engineering. 2,3 Biological activity of chitosan depend on their molecular weight and deacetylation degree. The deacetylation degree and molecular weight are important parameter, which could influences the performance of chitosan in many its application.…”
Section: Introductionmentioning
confidence: 99%
“…At the end of 2 nd week, there was progressive bone formation, and the end of 3 rd week, most socket filled with thicker bone trabecula surrounding interconnecting space. 2 The increasing expression of BMP-2 on wound healing process of dental extraction could be achieved by using chitosan gel. The aim of this study was to analyzed expressions of BMP-2 for 7, 14 and 21 days after using chitosan gel with different molecular weight on wound healing process of dental extraction.…”
Background: Bone morphogenetic protein-2 (BMP-2) is bone stimulator which capable of inducing differentiation of mesenchymal cells into osteoblast, stimulating bone formation in wound healing process of dental extraction. Chitosan is polymer composed N-acetyl-D-glucosamine unit that has been used in various applications
“…Osteocalcin and osteopontin expression marks the late stage of osteoblast differentiation, and BMP-2 is an important factor for osteoblast maturation and osteoblast activity. 2,3,15 In our study, the expressions of BMP-2 in 21 days observation after using chitosan gel with high molecular weight was decreasing. Probably, the activity of ALP has decreased.…”
Section: Discussionmentioning
confidence: 49%
“…The major proportion of bone formation and the maximum mineral density has occurred in the end of the 2 nd week. In the end of the 2 nd week the activity of ALP has decreased 2 The using of chitosan gel with high molecular weight could increasing the expression of BMP-2. BMP-2 is major growth factor in bone healing.…”
Section: Discussionmentioning
confidence: 99%
“…The BMP s , released during osteoclastic bone resorption, are capable of inducing differentiation of mesenchymal cells into osteoblasts (osteinduction), stimulating bone formation in both remodeling and repairing process. 1,2 Chitosan is carbohydrate copolymer composed of glucosamine and N-acetyl-D-glucosamine units. Chitosan has a number of properties including biocompatibility, biodegradability, mucoadhesiveness and wound healing capabilities that make it useful as a biomaterial.…”
Section: Introductionmentioning
confidence: 99%
“…3 Chitosan is very versatile and can be prepared as films, gels, sponges and other forms and has been used in various applications including wound healing and bone tissue engineering. 2,3 Biological activity of chitosan depend on their molecular weight and deacetylation degree. The deacetylation degree and molecular weight are important parameter, which could influences the performance of chitosan in many its application.…”
Section: Introductionmentioning
confidence: 99%
“…At the end of 2 nd week, there was progressive bone formation, and the end of 3 rd week, most socket filled with thicker bone trabecula surrounding interconnecting space. 2 The increasing expression of BMP-2 on wound healing process of dental extraction could be achieved by using chitosan gel. The aim of this study was to analyzed expressions of BMP-2 for 7, 14 and 21 days after using chitosan gel with different molecular weight on wound healing process of dental extraction.…”
Background: Bone morphogenetic protein-2 (BMP-2) is bone stimulator which capable of inducing differentiation of mesenchymal cells into osteoblast, stimulating bone formation in wound healing process of dental extraction. Chitosan is polymer composed N-acetyl-D-glucosamine unit that has been used in various applications
Hypertension alters the expression of RANK, RANKL, and OPG and delays the socket bone healing process. These alterations could influence some dental procedures such as orthodontic treatment and implant placement.
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