2007
DOI: 10.1590/s0103-64402007000100007
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Alveolar wound healing after implantation with a pool of commercially available bovine bone morphogenetic proteins (BMPs): a histometric study in rats

Abstract: The capacity of a commercially available pool of bovine bone morphogenetic proteins (BMPs) to stimulate osteogenesis in the rat alveolar healing was investigated by histometric analysis. Male rats were anesthetized and had their upper incisor extracted. A pool of purified bovine BMPs adsorbed to microgranular resorbable hydroxyapatite was agglutinated with bovine collagen and saline before implantation into the alveolar socket. The implanted and control rats (n=30 per group) were sacrificed 1 to 9 weeks postop… Show more

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Cited by 11 publications
(17 citation statements)
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“…Osteocalcin and osteopontin expression marks the late stage of osteoblast differentiation, and BMP-2 is an important factor for osteoblast maturation and osteoblast activity. 2,3,15 In our study, the expressions of BMP-2 in 21 days observation after using chitosan gel with high molecular weight was decreasing. Probably, the activity of ALP has decreased.…”
Section: Discussionmentioning
confidence: 49%
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“…Osteocalcin and osteopontin expression marks the late stage of osteoblast differentiation, and BMP-2 is an important factor for osteoblast maturation and osteoblast activity. 2,3,15 In our study, the expressions of BMP-2 in 21 days observation after using chitosan gel with high molecular weight was decreasing. Probably, the activity of ALP has decreased.…”
Section: Discussionmentioning
confidence: 49%
“…The major proportion of bone formation and the maximum mineral density has occurred in the end of the 2 nd week. In the end of the 2 nd week the activity of ALP has decreased 2 The using of chitosan gel with high molecular weight could increasing the expression of BMP-2. BMP-2 is major growth factor in bone healing.…”
Section: Discussionmentioning
confidence: 99%
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